背景和目的:糖尿病是一个重要的健康问题,促使人们寻找新的治疗策略。最近,研究人员一直致力于确定这种疾病进展的新标记。众所周知,脂肪因子,如前颗粒蛋白和vaspin,在调节脂质和碳水化合物代谢中起着至关重要的作用。材料和方法:这项单中心横断面研究旨在评估80例诊断为1型糖尿病(T1D)的儿童的血清颗粒蛋白前体和vaspin水平,并检查其与体重指数(BMI)的相关性。糖化血红蛋白,和脂质分布。该队列包括40名新诊断为糖尿病的儿童,40名长期糖尿病儿童(20名控制良好,20名控制不佳),和14名非糖尿病儿童作为对照组。使用夹心酶联免疫吸附测定法测定颗粒蛋白前体和vaspin水平。结果:研究组中的颗粒蛋白前体和vaspin浓度没有显着差异(分别为p=0.246和p=0.095)。在T1D中,男孩和女孩的脂肪因子水平没有统计学上的显着差异。控制良好的T1D,和控制不佳的T1D组。当根据BMI百分位数进行划分时,我们没有发现所有T1D儿童和健康对照者的颗粒蛋白前体和vaspin水平有任何差异。在T1D中观察到颗粒体蛋白浓度与儿童年龄之间呈负相关,控制良好的T1D,健康的团体。此外,T1D患儿的颗粒蛋白前体与BMI呈负相关。相比之下,健康儿童vaspin浓度与年龄呈正相关。结论:我们的研究提供了对不同1型糖尿病控制水平的儿科参与者中颗粒体蛋白和vaspin状态的新见解。然而,需要进一步研究涉及更大的患者队列和不同的性成熟阶段.
Background and Objectives: Diabetes is a significant health problem, prompting the search for new therapeutic strategies. Recently, researchers have focused on identifying novel markers for the progression of this condition. It is well established that adipokines, such as
progranulin and vaspin, play crucial roles in regulating lipid and carbohydrate metabolism. Materials and Methods: This single-center cross-sectional study aimed to assess serum
progranulin and vaspin levels in 80 children diagnosed with type 1 diabetes (T1D) and to examine their correlation with body mass index (BMI), glycated hemoglobin, and lipid profile. The cohort included 40 children newly diagnosed with diabetes, 40 children with long-term diabetes (20 well-controlled and 20 poorly controlled), and 14 non-diabetic children as a control group.
Progranulin and vaspin levels were determined using a sandwich enzyme-linked immunosorbent assay. Results: There were no significant differences in the progranulin and vaspin concentrations in the studied groups (p = 0.246 and p = 0.095, respectively). No statistically significant differences were noted in the levels of both adipokines among boys and girls within the T1D, well-controlled T1D, and poorly controlled T1D groups. We did not find any differences in the
progranulin and vaspin levels among all children with T1D and healthy controls when divided based on BMI percentiles. A negative correlation was observed between progranulin concentration and the age of children in the T1D, well-controlled T1D, and healthy groups. Furthermore,
progranulin correlated negatively with BMI among children with T1D. In contrast, vaspin concentration correlated positively with age among healthy children. Conclusions: Our study provides novel insights into the status of progranulin and vaspin among pediatric participants with varying levels of type 1 diabetes control. However, further research involving larger patient cohorts and different stages of sexual maturation is warranted.