■新生儿在出生后24-36小时内,甲状腺刺激激素(TSH)的初始激增会增加游离和总的三碘甲状腺原氨酸(T3)和四碘甲状腺原氨酸(T4),然后效果逐渐减弱。由于躯体和智力发育依赖于正常的甲状腺功能,尤其是在婴儿期,这些儿童的规范数据可能对诊断这一部分婴儿的甲状腺功能减退症具有巨大价值.早产儿甲状腺功能参数的综合标准值几乎不可用。这项研究的目的是确定早产新生儿甲状腺功能参数的标准值。
■对碘充足人群中甲状腺功能正常的母亲在妊娠34周和35周时出生的早产儿(n=102)进行了T3,T4,游离甲状腺素(FT4)和TSH的评估。出生后3-7天和1个月后再次进行。预期分娩日期(EDD)和Ballard评分用于确定妊娠持续时间。
■平均胎龄为34.7±0.41周。T3的平均值(±SD)(ng/dl),T4(μg/dl),出生后第3-7天的FT4(ng/ml)和TSH(μIU/ml)分别如下:156±44.6、12.8±3.7、1.50±0.54和7.13±6.04。大约4周龄,值分别为104±38.4、12.1±4.02、1.46±0.42和3.25±2.85。所有参数在4周左右发生了显著变化,除了FT4。这些参数均与出生时的胎龄或体重无关。生成百分位数形式的每个参数的规范值。
■这项研究为早产新生儿(出生34-35周)在出生后的第一周和大约4周后产生了甲状腺功能测试的标准值。
UNASSIGNED: Initial surge of thyroid-stimulating hormone (TSH) in neonates increases free and total triiodothyronine (T3) and tetraiodothyronine (T4) in 24-36 hours following birth, and the effect then gradually wanes off. As somatic and intellectual development is dependent on normal thyroid function especially in infancy, normative data in these children may be of immense value to diagnose hypothyroidism in this subset of infants. Comprehensive normative values of thyroid function parameters in preterm neonates are scarcely available. The objective of this study was to determine the normative value of thyroid function parameters in preterm neonates.
UNASSIGNED: Preterm neonates (n = 102) born at 34 and 35 weeks of gestation of euthyroid mothers from an iodine-sufficient population were evaluated for T3, T4, free thyroxine (FT4) and TSH during 3-7 days after birth and again after 1 month. The expected date of delivery (EDD) and Ballard score were used to identify the duration of gestation.
UNASSIGNED: The mean gestational age was 34.7 ± 0.41 weeks. The mean (± SD) for T3 (ng/dl), T4 (μg/dl), FT4 (ng/ml) and TSH (μIU/ml) on days 3-7 following birth was as follows: 156 ± 44.6, 12.8 ± 3.7, 1.50 ± 0.54 and 7.13 ± 6.04, respectively. Around 4 weeks of age, values changed to 104 ± 38.4, 12.1 ± 4.02, 1.46 ± 0.42 and 3.25 ± 2.85, respectively. All parameters changed significantly around 4 weeks, except FT4. None of the parameters were correlated with gestational age or body weight at birth. Normative values for each parameter in percentiles were generated.
UNASSIGNED: This study generated the normative values of the thyroid function test during the first week and after around 4 weeks of life for premature neonates (born at 34-35 weeks).