目的:对内分泌和核医学系的医务人员进行身体和细胞遗传学筛查,圣十字癌症中心,Kielce,波兰(DENM)在职业上暴露于131I。
方法:通过全身和手指无环剂量计监测暴露。甲状腺碘摄入量是通过配备两个半导体伽马辐射探测器的全身光谱仪测量的。使用胞质分裂阻滞微核试验和过早染色体凝聚技术来评估畸变评分。对一组29名工人进行了细胞遗传学分析,并与32名对照(健康供体)进行了比较,性别和年龄相匹配。
结果:平均而言,与对照组相比,暴露组显示出明显更高的遗传损伤频率和更高的增殖指数。吸烟状况,年龄和暴露时间影响两组的观察效果.在基于测量的低于和高于6Bq的131I活性将暴露组分层为两个亚组之后,没有观察到测量的生物标志物的差异。
结论:研究结果表明,基于全身和手指环剂量学的辐射防护原则,由全身光谱仪的活动测量支持,可能不足以监测职业暴露于131I的核医学人员的吸收剂量估计。此外,他们未来的健康风险受到混杂因素的影响。为了准确监测职业辐射暴露,需要对较大群体的物理和生物剂量估计进行直接评估。
OBJECTIVE: To physically and cytogenetically screen medical personnel of Department of Endocrinology and Nuclear Medicine, Holy Cross Cancer Center, Kielce, Poland (DENM) who are occupationally exposed to 131I.
METHODS: The exposure was monitored by whole-body and finger ring dosimeters. The thyroid iodine intake was measured by a whole-body spectrometer equipped with two semiconductor gamma radiation detectors. A cytokinesis-block micronucleus assay and the premature chromosome condensation technique were used to assess the aberration score. Cytogenetic analyses were carried out on a group of 29 workers and were compared to 32 controls (healthy donors), matched for gender and age.
RESULTS: On average, the exposed group showed a significantly higher frequency of genetic damage and a higher proliferation index compared to the control group. Smoking status, age and duration of exposure influenced the observed effects in both groups. No differences in measured biomarkers were observed after stratification of the exposed group into two subgroups based on the measured 131I activity below and above 6 Bq.
CONCLUSIONS: The findings suggest that radiation protection principles based on whole-body and finger ring dosimetry, supported by activity measurements with a whole-body spectrometer, may be insufficient to monitor the absorbed dose estimation of the nuclear medicine staff who are occupationally exposed to 131I. Furthermore, their future health risks are influenced by confounders. Direct assessments comparing physical and biological dose estimations on the larger group are needed to accurately monitor occupational radiation exposure.