目的:在植入前基因检测结果和妊娠结局方面,评估通过卵胞浆内单精子注射授精是否比体外受精对非男性因素不育症有任何益处。
方法:辅助生殖技术协会数据库的回顾性队列研究。
方法:接受体外受精或卵胞浆内单精子注射的患者进行非整倍性周期非男性因素植入前遗传学检测。
方法:体外受精与卵胞浆内单精子注射主要结局指标:主要结局为适于移植的胚胎比例和活产率.次要结果包括适用于周期移植的胚胎的亚组分析<35y/o,取出≤6个卵母细胞vs.>6个卵母细胞回收,和无法解释的不孕症。此外,评估了分娩时的胎龄和体外受精和胞浆内单精子注射之间的出生体重。
结果:总共评估了30,446个非整倍体周期的非男性因素植入前遗传学诊断,其中体外受精4867例,卵胞浆内单精子注射25579例。根据排除标准并对任何必要的混杂变量进行调整,在体外受精和胞浆内单精子注射周期之间,适合移植的胚胎没有显着差异,41.6%(40.6%,42.6%)与42.5%(42.0%,42.9%),分别或活产率,50.1%(37.8%,62.4%)与50.8%(38.5%,62.9%),分别。
结论:在接受非整倍体植入前基因检测的非男性因素周期中,体外受精和卵胞浆内单精子注射在适于移植的胚胎率和活产率方面没有显著差异。
OBJECTIVE: To evaluate whether insemination via intracytoplasmic sperm injection (ICSI) provides any benefit over in vitro fertilization (IVF) insemination for nonmale factor infertility with respect to preimplantation genetic testing (PGT) results and pregnancy outcome.
METHODS: Retrospective cohort study of the Society for Assisted Reproductive Technology database.
METHODS: US-based fertility clinics reporting to the Society for Assisted Reprodcutive Technology.
METHODS: Patients undergoing IVF or ICSI inseminations in nonmale factor PGT for aneuploidy cycles.
METHODS: In vitro fertilization vs. ICSI inseminations.
METHODS: Primary outcomes were the percentage of embryos suitable for transfer and live birth rates (LBRs). Secondary outcomes included subgroup analysis for embryos suitable for transfer on cycles from patients ≥35-year-old vs. <35-year-old, ≤6 oocytes retrieved vs. >6 oocytes retrieved, and unexplained infertility. Additionally, gestational age at delivery and birth weight between IVF and ICSI inseminations were evaluated.
RESULTS: A total of 30,446 nonmale factor PGT diagnoses for aneuploidy cycles were evaluated, of which 4,867 were IVF inseminations and 25,579 were ICSI inseminations. Following exclusion criteria and adjustment for any necessary confounding variables, no significant differences existed in embryos suitable for transfer between IVF and ICSI treatment cycles, 41.6% (40.6%, 42.6%) vs. 42.5% (42.0%, 42.9%), respectively, or in LBRs, 50.1% (37.8, 62.4%) vs. 50.8% (38.5%, 62.9%), respectively.
CONCLUSIONS: There were no significant differences in the rates of embryos suitable for transfer and LBRs between IVF and ICSI inseminations in nonmale factor cycles undergoing PGT for aneuploidy.