未经证实:妊娠期糖尿病(GDM)是一种代谢紊乱,可能使孕妇易患2型糖尿病或导致后代严重不良结局。被认为与这种疾病背后的病理学有关的因素之一是微生物组。在这次系统审查中,我们全面回顾了有关GDM孕妇及其后代不同部位微生物群变化的文献.
UNASSIGNED:在包括MEDLINE(PubMed)在内的主要数据库中进行了全面搜索,Scopus,和WebofSciences截至2021年8月。人口统计数据,方法论,根据GDM孕妇及其后代的微生物组类型,提取并分类微生物组改变。使用纽卡斯尔-渥太华量表(NOS)评估研究质量。
未经评估:在检索到的49篇文章中,这些发现在α和β多样性的变化水平上是可变的,门的富集或耗尽,属,物种和OTU,在每个微生物组类型中。尽管结果之间存在一些不一致之处,在肠道中看到了明显的变化模式,口服,GDM和肠道女性的阴道微生物组,口服,和他们后代的胎盘微生物组。
未经证实:尽管在GDM病例中观察到不同区域微生物组的改变,研究之间的不一致使我们无法识别独特的模式。然而,结果似乎很有希望,需要进一步的研究来克服与人口统计学和方法论相关的混杂因素。
Gestational diabetes mellitus (GDM) is a metabolic disorder that might predispose pregnant women to develop type 2 Diabetes Mellitus or lead to severe adverse outcomes in their offspring. One of the factors that have been thought to be involved in the pathology behind this disorder is the microbiome. In this systematic review, we comprehensively review the documents regarding the microbiota alterations in different tracts of pregnant women with GDM and their offspring.
A comprehensive search was conducted in major databases including MEDLINE (PubMed), Scopus, and Web of sciences up to August 2021. Data on the demographics, methodology, and microbiome alterations were extracted and classified according to the type of microbiome in pregnant women with GDM and their offspring. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS).
In 49 articles which were retrieved, the findings were variable on the level of changes in alpha and beta diversity, enrichment or depletion in phyla, genera, species and OTUs, in each microbiome type. Although there were some inconsistencies among the results, a pattern of significant alterations was seen in the gut, oral, vaginal microbiome of women with GDM and gut, oral, and placental microbiome of their offspring.
Even though the alteration of the microbiome of the different tracts was seen in the cases of GDM, the inconsistency among the studies prevents us from identifying unique pattern. However, the results seem promising and further studies that overcome the confounding factors related to the demographics and methodology are needed.