目的:本研究的目的是调查鼻窦嗅觉功能障碍(OD)患者的嗅觉波动(OF)是否明显。
方法:回顾性调查包括18岁或以上的患者,他咨询了三级嗅觉丧失转诊中心。排除嗅觉功能正常的患者。患者回答了关于他们嗅觉症状的结构化问卷,关于OF的存在及其平均频率的具体问题,振幅,持续时间,自最近一次以来,以及自我报告的相关症状。患者还接受了临床评估,包括结构化病史和体格检查,包括鼻内窥镜检查。此外,我们用Sniffin棒评估鼻前嗅觉功能,和味觉功能使用“味觉喷雾剂”。
结果:参与者包括131名男性和205名女性(n=336),年龄18至86岁(平均50,SD16)。患者报告的波动最常发生在鼻窦(38%),特发性(29%),和病毒后(29%)OD。OF的振幅在病毒后OD中最高(p=0.009)。平均频率,持续时间,和自最近波动以来的时间在组间没有显着差异(所有p/s>0.42)。OF患者的气味辨别(p=0.002)和识别(p=0.017)得分较高。
结论:OF的振幅可能有助于区分病毒后与OD的其他原因,尤其是在表现为鼻窦疾病的模棱两可症状的患者中。
OBJECTIVE: The aim of the study was to investigate whether olfactory fluctuations (OF) are pronounced in patients with sinonasal olfactory dysfunction (OD).
METHODS: The retrospective investigation included patients aged 18 years or older, who consulted a tertiary referral center for olfactory loss. Patients with normal smell function were excluded. Patients answered a structured questionnaire about their olfactory symptoms, with specific questions related to the presence of OF and its average frequency, amplitude, duration, time since most recent OF, and associated symptoms of self-reported OF. Patients also underwent clinical evaluation including a structured medical history and physical examination including nasal endoscopy. In addition, we assessed orthonasal olfactory function using Sniffin\' Sticks, and gustatory function using \"taste sprays\".
RESULTS: Participants included 131 men and 205 women (n = 336), aged 18 to 86 years (mean 50, SD 16). Patient-reported fluctuations occurred most frequently in sinonasal (38%), idiopathic (29%), and
postviral (29%) OD. Amplitude of OF was highest in
postviral OD (p = 0.009). Average frequency, duration, and the time since the most recent fluctuation were not significantly different between groups (all p\'s > 0.42). Odor discrimination (p = 0.002) and identification (p = 0.017) scores were higher among those individuals with OF.
CONCLUSIONS: Amplitude of OF may help distinguish
postviral from other causes of OD, especially in patients presenting with equivocal symptoms of sinonasal disease.