目的:尽管EQ-5D-3L仪器的人口规范自2000年以来在匈牙利就已存在,但其评估基于英国(UK)的价值集。我们的目标是通过使用自2020年以来可用的新匈牙利值集来估计EQ-5D-3L的人口规范,以将范围扩展到青少年,并与2000年的规范进行比较。
方法:2022年进行了代表匈牙利人口的EQ-5D-3L横断面调查。按年龄和性别分析EQ-5D-3L维响应,并通过估计人口频率的95%置信区间与2000年的调查进行比较;指数值通过两个值集进行评估。
结果:总之,11,910名受访者,12岁或以上(12至17岁之间的578),完成了EQ-5D-3L。与2000年相比,男女(35-64岁)在疼痛/不适和焦虑/抑郁方面的报告问题均有显着改善。在44岁以下,男女的EQ-5D-3L指数均为0.98,而在55岁以上,男性的指数值往往高于女性,差异随着年龄的增长而增大。与2000年相比,年龄在18至74岁之间的两性的尺寸响应的改善也转化为数字上更高的指数值。多元回归分析显示,较高的文化程度,年龄较低,更大的家庭尺寸,积极的职业状态与较高的指数值相关。
结论:在过去的22年里,匈牙利中老年男性和女性的HRQoL有了很大改善。
健康状况可以通过与健康相关的生活质量指标的组合来描述。“值集”是健康状态的优选程度的数值表达式。提供与人群健康相关的生活质量估计(也称为“人群规范”)有望提高患者级临床决策的准确性,以及卫生经济和公共卫生研究。然而,对这些健康状况的偏好受到文化的影响,导致不同人群的差异。虽然自2000年以来,匈牙利就有针对成人的EQ-5D-3L仪器的答复,但对这些答复的评估是基于英国的“价值集”,而不是匈牙利的。这项研究,利用EQ-5D-3L仪器新推出的匈牙利“价值集”(自2020年起可用),提供更大的样本量,纳入青少年,与2000年进行的先前研究相比,抽样可能有所改善。两项调查的比较使我们能够估计20年时间范围内人口的维度反应和总体健康相关生活质量的变化。同时我们还比较了不同的“价值集”对健康相关生活质量评估的影响。在中老年人中观察到EQ-5D-3L的改善。
OBJECTIVE: Although population norms of the EQ-5D-3L instrument had been available in Hungary since 2000, their evaluation was based on a United Kingdom (UK) value set. Our objective was to estimate the population norms for EQ-5D-3L by using the new Hungarian value set available since 2020, to extend the scope to adolescents, and to compare with norms from 2000.
METHODS: A cross sectional EQ-5D-3L survey representative of the Hungarian population was conducted in 2022. The EQ-5D-3L dimensional responses were analyzed by age and sex and compared with the survey from 2000, by estimating population frequencies with their 95% confidence intervals; index values were evaluated by both value sets.
RESULTS: Altogether, 11,910 respondents, aged 12 or more (578 between 12 and 17), completed the EQ-5D-3L. There was a notable improvement in reporting problems for both sexes (age 35-64) regarding the pain/discomfort and anxiety/depression compared to 2000. Below the age 44, both sexes had an EQ-5D-3L index plateau of 0.98, while above the age 55, men tended to have numerically higher index values compared to women, with the difference increasing with older age. Improvement in dimensional responses were also translated to numerically higher index values for both sexes between ages 18 and 74 compared to 2000. Multivariate regression analysis showed that higher educational attainment, lower age, larger household size, and active occupational status were associated with higher index values.
CONCLUSIONS: Over the past 22 years, there was a large improvement in HRQoL of the middle-aged to elderly men and women in Hungary.
Health states can be described by a combination of statements of health-related quality of life measures. ‘Value sets’ are numerical expressions of how preferred a health state is. The provision of population-level health-related quality of life estimates (also known as ‘population norms’) are expected to improve the precision of patient-level clinical decision making, and health economic and public health studies. However, preference towards these health states is influenced by culture, resulting in differences across populations. While responses for the EQ-5D-3L instrument for adults have been available in Hungary since 2000, the evaluation of these responses was based on a ‘value set’ from the United Kingdom, rather than a Hungarian one.This research, utilizing the newly introduced Hungarian ‘value set’ (available since 2020) for the EQ-5D-3L instrument, offers a larger sample size, inclusion of adolescents and potentially improved sampling compared to the prior research conducted in 2000. Comparison of the two surveys allows us to estimate changes in both dimensional responses and overall health-related quality of life of the population over a 20-year time horizon, while we also compare the impact of different ‘value sets’ on health-related quality of life assessment. A large EQ-5D-3L improvement was observed in middle-aged-to-elderly people.