■这项研究的目的是确定增加常染色体显性遗传多囊肾病(ADPKD)患者的水摄入量对健康相关生活质量(HRQoL)的纵向变化的长期影响。
■自行完成的HRQoL(使用KDQoL-SF,v.1.3问卷)每年在3年随机对照临床试验的参与者中进行评估(n=187),分配(1:1)要么增加水摄入量,将尿渗透压降低至≤270摩尔/千克(由饮食指导实施,自我监控工具,短信)或继续常规的取水。
■总的来说,96%和81.8%的参与者(n=187)在基线和最终研究访问时完成了问卷,分别。在基线,两组的身体成分汇总评分(PCS)和心理成分汇总评分(MCS)相似(P>0.05),两组得分最低的5个维度为:精力和疲劳;一般和整体健康;睡眠;情绪健康;疼痛.在每一组中,随着时间的推移没有纵向变化。在最后一次访问中,与常规取水组48.8±9.3相比,增加取水组的PCS较高(51.3±7.6,平均值±标准差);P=0.037),而MCS在数值上相似.PCS的改善是由于较高的身体功能和疼痛的子量表值(均P<0.05)。通过多变量分析,只有基线PCS和身高校正后的总肾脏体积与最终PCS相关(P<0.05).
■HRQoL分数在3年内保持稳定,并且没有受到增加水摄入量的干预措施的不利影响。未来的研究应评估高PCS在水摄入量增加组中的临床意义。
UNASSIGNED: The aim of this study was to determine the long-term effect of increasing water intake in patients with autosomal dominant polycystic kidney disease (ADPKD) on longitudinal changes in health-related quality of life (HRQoL) in the setting of a clinical trial.
UNASSIGNED: Self-completed HRQoL (using the KDQoL-SF, v.1.3 questionnaire) was assessed annually in participants of a 3-year randomized controlled clinical trial (n = 187), allocated (1:1) either to increase water intake to reduce urine osmolality to ≤270 mosmol/kg (implemented by dietetic coaching, self-monitoring tools, text messaging) or continue usual water intake.
UNASSIGNED: Overall, 96% and 81.8% of participants (n = 187) completed the questionnaire at the baseline and final study visits, respectively. At baseline, the physical component summary score (PCS) and mental component summary score (MCS) were similar in the two groups (P > 0.05) and the five dimensions with the lowest scores in both groups were: energy and fatigue; general and overall health; sleep; emotional well-being; and pain. Within each group, there were no longitudinal changes over time. At the final visit, the PCS was higher in the increased water intake group (51.3 ± 7.6, mean ± standard deviation) compared to the usual water intake group 48.8 ± 9.3; P = 0.037) whereas the MCS was numerically similar. The improvement in the PCS was due to higher sub-scale values for physical functioning and pain (both P < 0.05). By multivariate analysis, only baseline PCS and height-corrected total kidney volume were associated with the final PCS (P < 0.05).
UNASSIGNED: HRQoL scores remained stable over a 3 year period, and were not adversely affected by the intervention to increase water intake. Future studies should evaluate the clinical significance of the higher PCS in the increased water intake group.