Polidocanol instillation

  • 文章类型: Journal Article
    背景:动脉瘤样骨囊肿(ABC)是一种良性的,而是骨的局部侵袭性囊性病变.它通常发生在青少年和年轻人的长骨干phy端,但也可能影响骨盆。
    方法:这项单中心研究是对17例原发性骨盆ABCs患者的回顾性研究。与病灶内刮治或边缘切除术相比,它研究了脊髓灰质炎滴注作为骨盆ABC微创治疗选择的重要性。
    结果:研究中纳入了17例诊断为骨盆原发性ABC的患者。6名患者为男性(35%),11名患者为女性(65%);平均年龄为18(9-49)岁。随访时间12~136个月,平均50个月。最常见的表现位置是耻骨(6;35%),其次是髂骨(6;35%),骶骨(3;18%)和坐骨(2;12%)。8例患者通过使用佐剂进行病灶内刮治,一名患者通过边缘切除术,七个通过顺序滴注脊髓灰质炎和一名患者通过简单观察。五名患者接受了额外的经动脉栓塞。病灶内刮除后,有4/8例(50%)发现局部复发。经滴注治疗后,6例患者(86%)病情稳定,无复发,只有1例患者(14%)患有持续性疾病,需要额外治疗,因此在随访中转为病灶内刮治,无局部复发.
    结论:依次滴注脊髓灰质炎是有希望的,骨盆ABCs的微创治疗方法,可以很好地结合经动脉栓塞。
    BACKGROUND: The aneurysmal bone cyst (ABC) is a benign, but locally aggressive cystic lesion of the bone. It usually occurs in the metaphysis of long bones of adolescents and young adults but can also affect the pelvis.
    METHODS: This single-center study is a retrospective review of 17 patients with primary ABCs of the pelvis. It examines the importance of polidocanol instillations as minimally invasive treatment option for ABCs of the pelvis compared to intralesional curettage or marginal resection.
    RESULTS: Seventeen patients with the diagnosis of a primary ABC of the pelvis were included in the study. Six patients were male (35%) and 11 patients female (65%); the mean age was 18 (9-49) years. The mean follow-up time was 50 months (12-136 months). The most common location of manifestation was the pubis (6; 35%), followed by the ilium (6; 35%), the sacrum (3; 18%) and the ischium (2; 12%). Eight patients were treated by intralesional curettage with the use of adjuvants, one patient by marginal resection, seven by sequential instillation of polidocanol and one patient by simple observation. Five patients received an additional transarterial embolization. After intralesional curettage local recurrence was detected in 4/8 cases (50%). After instillation therapy six patients (86%) had a stable disease without recurrence, only one patient (14%) had a persistent disease with need of additional treatment and was therefore converted to intralesional curettage without local recurrence in the follow-up.
    CONCLUSIONS: Sequential instillations of polidocanol are a promising, minimally invasive treatment method for ABCs of the pelvis and can be well combined with transarterial embolization.
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  • 文章类型: Journal Article
    (1)背景:动脉瘤样骨囊肿(ABC)是一种良性,局部侵袭性肿瘤。文献中描述了不同的治疗方式,即整块切除,病灶内刮治和经皮硬化治疗。(2)方法:这项单中心研究是对74例接受手术治疗或脊髓灰质炎滴注的原发性ABC患者的回顾。比较了使用MRI和常规X射线照片进行的囊肿体积测量。(3)结果:基于MRI的囊肿介入前平均体积为44.07cm3,X线平均体积为27.27cm3。需要进一步治疗的病灶内刮治后的复发率为38.2%(13/34)。滴注policanol显示初始囊肿体积显着减少(p<0.001),但29/32例(90.6%)发生了持续性疾病。在这29例病例中,有10例(34.5%)需要进一步治疗。整块切除(8例)后,2例(25%)发生局部复发,在一种情况下需要进一步治疗。(4)结论:在ABCs的检查中,MRI扫描优于双平面X线片。与病灶内刮治相比,顺序经皮滴注脊髓灰质炎醇在原发性ABC的治疗中同样有效。然而,预计会有几次灌输。在相当多的案例中,可能需要转换为病灶内刮治或整块切除。
    (1) Background: An aneurysmal bone cyst (ABC) is a benign, locally aggressive tumor. Different treatment modalities are described in the literature i.e., en bloc resection, intralesional curettage and percutaneous sclerotherapy. (2) Methods: This single-center study is a review of 74 patients with primary ABCs who underwent a surgical treatment or polidocanol instillation. Cyst volume measurements using MRI and conventional radiographs are compared. (3) Results: The mean pre-interventional MRI-based cyst volume was 44.07 cm3 and the mean radiographic volume was 27.27 cm3. The recurrence rate after intralesional curettage with the need for further treatment was 38.2% (13/34). The instillation of polidocanol showed a significant reduction of the initial cyst volume (p < 0.001) but a persistent disease occurred in 29/32 cases (90.6%). In 10 of these 29 cases (34.5%) further treatment was necessary. After en bloc resection (eight cases) a local recurrence occurred in two cases (25%), in one case with the need for further treatment. (4) Conclusions: MRI scans are superior to biplanar radiographs in the examination of ABCs. Sequential percutaneous instillations of polidocanol are equally effective in the therapy of primary ABCs compared to intralesional curettage. However, several instillations have to be expected. In a considerable number of cases, a conversion to intralesional curettage or en bloc resection may be necessary.
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  • 文章类型: Case Reports
    背景:动脉瘤样骨囊肿(ABC)是一种良性,发生在儿童和成年早期的局部侵袭性肿瘤。它通常会影响长骨的干phy端,但也可能发生在脚上。
    方法:这项单中心研究是对10例原发性足ABC患者进行病灶内刮治或脊髓灰质炎滴注的回顾性研究。
    结果:病灶内刮除后3/5例局部复发。滴注policanol显示初始囊肿体积显着减少(p=0.0267)。在滴注亚组中,三例患者实现了基本的完全愈合。由于持续的疾病,有2例病例在随访中被转换为病灶内刮治,而没有局部复发。
    结论:经皮滴注脊髓灰质炎是一种对足部ABC,尤其是对小骨骼的微创治疗选择。然而,几个顺序滴注和转换为病灶内刮治可能是必要的。
    BACKGROUND: Aneurysmal bone cyst (ABC) is a benign, locally aggressive tumor that occurs in childhood and early adulthood. It usually affects the metaphysis of long bones but can also occur in the foot.
    METHODS: This single-center study is a retrospective review of ten patients with primary ABCs of the foot which underwent an intralesional curettage or a polidocanol instillation.
    RESULTS: After intralesional curettage a local recurrence was observed in 3/5 cases. The instillation of polidocanol showed a significant reduction of the initial cyst volume (p=0.0267). In the instillation subgroup a primary complete healing was achieved in three cases. Due to a persisting disease two cases were converted to intralesional curettage without local recurrence in the follow-up.
    CONCLUSIONS: Percutaneous instillation of polidocanol is a minimally invasive treatment option for ABCs of the foot and especially for small bones. Nevertheless, several sequential instillations and a conversion to intralesional curettage can be necessary.
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