■在亚洲国家中,恶性扁豆(LM)和恶性扁豆黑色素瘤(LMM)很少见。LM的组织病理学诊断通常具有挑战性,误诊是常见的。尽管LM/LMM的组织病理学特征是已知的,对它们的统计分析几乎没有报道。在这项研究中,我们旨在调查韩国患者LM/LMM的组织病理学特征,并确定区分LM和良性扁豆的关键组织病理学线索。
■我们对2011年至2022年在我们中心诊断为LM/LMM的患者的临床和组织病理学特征进行了回顾性研究。我们根据以前的文献,根据16种病理标准评估了每种情况下的组织病理学特征。对经病理证实的良性扁豆病例进行分析比较。
■分析了21例患者(10例LM和11例LMM)。LM和良性扁豆的特征之间存在统计学上的显着差异(N=10),包括整体结构的不对称性(p<0.001),细胞学异型性(p<0.001),主要的单细胞增殖(p<0.001),黑素细胞巢(p=0.033),黑素细胞形成行(p=0.003),黑素细胞的类脂扩散(p<0.001),和不典型黑素细胞侵袭毛囊(p<0.001)。“年龄≥60岁”组的日光弹性增生程度更为严重(p=0.015),和“直径≥20mm”组(p=0.043)。在60岁以上的年龄组(p=0.015)和直径≥20mm的组中,存在细长的网状脊的情况较少见。“侵袭与有丝分裂有关(p=0.001,OR49.285),多核细胞(p=0.035,OR17.769),和淋巴细胞浸润程度(p=0.004)。
■本研究调查了韩国人LM和LMM的临床和组织病理学特征。尽管组织病理学诊断具有挑战性,尤其是在LM的早期阶段,我们的数据显示了建筑的重要组织病理学变化,细胞学,和皮肤模式。考虑到LM/LMM的潜在攻击性,必须认识到其组织病理学特征并提供及时的管理。
UNASSIGNED: Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are rare in Asian countries. The histopathological diagnosis of LM is often challenging, and misdiagnosis is common. Although histopathologic features of LM/LMM are known, statistical analysis of them were scarcely reported. In this study, we aimed to investigate the histopathological characteristics of LM/LMM in Korean patients and identify key histopathological clues distinguishing LM from benign lentigo.
UNASSIGNED: We performed a retrospective study of the clinical and histopathological features of patients diagnosed with LM/LMM at our center between 2011 and 2022. We assessed the histopathological features in each case based on 16 pathological criteria according to previous literature. Pathologically confirmed cases of benign lentigo were analyzed for comparison.
UNASSIGNED: Twenty-one patients (10 with LM and 11 with LMM) were analyzed. Several statistically significant difference existed between the features of LM and benign lentigo (N = 10), including asymmetry of overall structure (p < 0.001), cytologic atypia (p < 0.001), predominant single-cell proliferation (p < 0.001), melanocytic nests (p = 0.033), melanocytes forming rows (p = 0.003), pagetoid spread of melanocytes (p < 0.001), and hair follicle invasion by atypical melanocytes (p < 0.001). Degree of solar elastosis was more severe in group \"Age ≥ 60\" (p = 0.015), and group \"Diameter ≥ 20 mm\" (p = 0.043). Presence of elongated rete ridges were less common in the older than 60 age group (p = 0.015) and group \"Diameter ≥ 20 mm.\" Invasion was associated with mitosis (p = 0.001, OR 49.285), multinucleated cells (p = 0.035, OR 17.769), and degree of lymphocyte infiltration (p = 0.004).
UNASSIGNED: This study investigated the clinical and histopathologic characteristics of LM and LMM in Koreans. Although histopathological diagnosis is challenging, especially in the early stages of LM, our data showed essential histopathological changes in architectural, cytological, and dermal patterns. Considering the potential aggressiveness of LM/LMM, it is essential to recognize its histopathological features and provide timely management.