大多数投放市场的片剂用可溶于水的聚合物包衣。ColorconInc.的OpadryII85系列,是自20世纪90年代以来销售的PVA基产品家族。尽管发表了许多关于PVA性质的出版物,到目前为止,已经进行了有限的工作来确定物理化学参数(即,UV光,高温,和相对湿度),这可能会影响PVA基涂料的性能。为此,我们对OpadryOrangeII或该涂层的某些选定成分制成的样品进行了人工老化过程,并通过多学科方法对其进行了分析。使用,例如,FTIR,NMR,流变学,和DMTA测量。这样,我们分析了OpadryOrangeII配方的关键成分的影响,如二氧化钛和氢氧化铝,老化条件下的涂层特性。
Most tablets put on the market are coated with polymers soluble in water. The Opadry II 85 series from Colorcon Inc., is a family of PVA-based products marketed since the 1990s. Despite numerous publications on the properties of PVA, to date, limited work has been undertaken to determine the physico-chemical parameters (i.e., UV light, high temperature, and relative humidity) that could affect the performance of PVA-based coatings. To this end, we performed artificial ageing processes on samples made of Opadry Orange II or of some selected components of this coating and analysed them by means of a multidisciplinary approach, using, for example, FTIR, NMR, rheology, and DMTA measurements. In this way, we analysed the influence of the critical components of the Opadry Orange II formula, such as titanium dioxide and aluminium hydroxide, on the coating characteristics under ageing conditions.