背景:对(聚)酚暴露的见解代表了一种可调节慢性胰腺炎(CP)炎症的可变因素,然而,摄入量特征不佳,评估方法不发达。
目的:目的是使用Phenol-Explorer数据库开发和测试一种从90天食物频率问卷(FFQ)中估算(聚)酚摄入量的方法,并通过分析先前收集的横截面数据来确定CP患者与对照组的饮食模式。
方法:从大型门诊诊所招募了52名CP患者和48名对照,学术机构。为了评估估计膳食(聚)酚暴露的拟议方法的可行性,我们完成了对FFQ数据的回顾性分析.Mann-WhitneyU检验用于按组比较(聚)酚摄入量;Spearman相关性和多变量调整的对数线性关联用于比较(聚)酚摄入量与样本中的饮食评分。
结果:从FFQs中估算(聚)酚摄入量是可行的,并且在先前报告的摄入量范围内得出了估算值。CP与对照组相比,总(聚)酚摄入量显着降低(463与567mg/1000kcal;p=0.041)。在调整后的分析中,较高的总(聚)酚摄入量与较高的HEI-2015相关(r=0.34,p<0.001),aMED(r=0.22,p=0.007),EDIH(r=0.29,p<0.001),和EDIP评分(r=0.35,p<0.001),代表较高的整体饮食质量和较低的胰岛素和抗炎饮食潜力,分别。
结论:使用增强方法从FFQ获得总(聚)酚摄入量是可行的。CP患者的总(聚)酚摄入量较低,膳食模式指数较差,因此支持未来在这一人群中进行量身定制的饮食干预研究。
BACKGROUND: Insights into (poly)phenol exposure represent a modifiable factor that may modulate inflammation in chronic pancreatitis (CP), yet intake is poorly characterized and methods for assessment are underdeveloped.
OBJECTIVE: The aims are to develop and test a method for estimating (poly)phenol intake from a 90-day food frequency questionnaire (FFQ) using the Phenol-Explorer database and determine associations with dietary patterns in CP patients versus controls via analysis of previously collected cross-sectional data.
METHODS: Fifty-two CP patients and 48 controls were recruited from an ambulatory clinic at a large, academic institution. To assess the feasibility of the proposed methodology for estimating dietary (poly)phenol exposure, a retrospective analysis of FFQ data was completed. Mann-Whitney U tests were used to compare (poly)phenol intake by group; Spearman correlations and multivariable-adjusted log-linear associations were used to compare (poly)phenol intakes with dietary scores within the sample.
RESULTS: Estimation of (poly)phenol intake from FFQs was feasible and produced estimates within a range of intake previously reported. Total (poly)phenol intake was significantly lower in CP vs controls (463 vs. 567mg/1000kcal; p = 0.041). In adjusted analyses, higher total (poly)phenol intake was associated with higher HEI-2015 (r = 0.34, p < 0.001), aMED (r = 0.22, p = 0.007), EDIH (r = 0.29, p < 0.001), and EDIP scores (r = 0.35, p < 0.001), representing higher overall diet quality and lower insulinemic and anti-inflammatory dietary potentials, respectively.
CONCLUSIONS: Using enhanced methods to derive total (poly)phenol intake from an FFQ is feasible. Those with CP have lower total (poly)phenol intake and less favorable dietary pattern indices, thus supporting future tailored dietary intervention studies in this population.