目的:这篇综述集中在Unani医学系统中痴呆的概念,有关MajoonVaj植物化学的最新信息,促智,CNS活动,并为未来研究提供潜在机会的见解。
方法:关于MajoonVaj的经典文献,从包括Unani药典在内的近13本经典Unani书籍中收集了治疗用途。生药学的信息,MajoonVaj及其成分的植物化学和药理活性是通过浏览互联网(PubMed,ScienceDirect,Wiley在线图书馆,谷歌学者,ResearchGate)。调查了相关的主要来源,分析,并包括在这次审查中。用于浏览的关键字是MajoonVaj,痴呆症,促智药,鱿鱼,Pipernigram,生姜,Nigellasativa,CarumCarvi,Plumbagozeylanica,和β-细辛醚。截至2021年7月收集了相关资料,并使用ACD/ChemSketch软件绘制了化学结构。物种名称和同义词已与WFO(2021):世界植物区系在线(http://www。worldfloraonline.org)\'植物列表的更新版本。\'
结果:MajoonVaj含有过量的生物活性化合物,例如,生物碱,酚类物质,黄酮类化合物,单宁,二萜,香豆素,碳水化合物,和固定油及其成分具有广泛的药理特性,包括认知增强,神经保护,抗炎,抗氧化和抗菌性能。
结论:Unani医学的文献在讨论记忆障碍的病理生理基础方面相当丰富。它认为记忆,保留,和检索是由涉及各种院系的复杂过程调节的。MajoonVaj似乎在治疗痴呆症方面具有巨大的治疗应用潜力,因此鼓励在该领域进行更多的临床前和临床试验。
OBJECTIVE: This review focused on the concept of dementia in the Unani system of medicine and comprehensive, updated information on Majoon Vaj about the phytochemistry, nootropic, CNS activities and provide insights into potential opportunities for future research.
METHODS: The classical literature on Majoon Vaj for its anti-dementic properties, and therapeutic uses were gathered from nearly thirteen classical Unani books including Unani Pharmacopoeia. The information of pharmacognosy, phytochemical and pharmacological activities of Majoon Vaj and its ingredient was collected by browsing the Internet (PubMed, ScienceDirect, Wiley online library, Google Scholar, ResearchGate). The relevant primary sources were probed, analysed, and included in this review. The keywords used to browse were Majoon Vaj, Dementia, Nootropic, Acorus calamus, Piper nigram, Zingiber officinalis, Nigella sativa, Carum carvi, Plumbago zeylanica, and β-asarone. Relevant Sources were gathered up to July 2021, and the chemical structures were drawn using ACD/ChemSketch software. The species name and synonyms were checked with WFO (2021): World Flora online (http://www.worldfloraonline.org) an updated version of \'The Plant List.\'
RESULTS: Majoon Vaj contains an excess of bioactive compounds e.g., alkaloids, phenols, flavonoids, tannins, diterpenes, coumarins, carbohydrates, and fixed oils and its ingredients possess broad pharmacological properties, including cognitive-enhancing, neuroprotective, anti-inflammatory, antioxidant and antimicrobial properties.
CONCLUSIONS: The literature of Unani medicine is quite rich in discussing the pathophysiological basis of memory disorders. It argues that memory, retention, and retrieval are regulated by a complex process involving various faculties. Majoon Vaj seems to have great potential for therapeutic applications in the treatment of dementia and thus encourage more preclinical and clinical trials in this field.