■自2018年以来,广西百日咳病例明显增加。本研究的目的是评估常住人口中百日咳的抗体水平和感染状况。
■从2018年8月至11月收集了来自居民的总共10,215份血清样本,并使用酶联免疫吸附测定(ELISA)测试了抗百日咳IgG和毒素IgG。
■在收集的样本中,1,833(17.94%)的抗百日咳IgG检测呈阳性,中值浓度为16.06IU/mL。4岁以下儿童抗体水平<10IU/mL占60%以上,但随着年龄的增长而下降,而其他三个水平(10-40,40-50和≥50IU/mL)的百分比几乎随年龄增长而增加(P<0.001)。此外,选择了7,924个样品用于抗百日咳毒素IgG,其中653例(8.24%)检测呈阳性(≥40IU/mL),中位浓度为5.89IU/mL,204例参与者(2.56%)近期出现百日咳感染(≥100IU/mL).在不同年龄段中,在11-20岁时观察到最高的阳性率和近期感染率,5岁时阳性率最低,4岁时的近期感染率最低(分别为P<0.001,P=0.005)。
■调查结果显示,广西各年龄组对百日咳缺乏免疫力,这是导致2018年百日咳复发的主要因素之一。此外,广西百日咳患病率较高,它的发病率被严重低估了,尤其是青少年和成年人。
UNASSIGNED: Pertussis cases have increased markedly since 2018 in Guangxi. The aim of this study was to evaluate antibody levels and the infection status of pertussis in the resident population.
UNASSIGNED: A total of 10,215 serum samples from residents were collected from August-November 2018 and tested for anti-pertussis IgG and toxin IgG using the enzyme-linked immunosorbent assay (ELISA).
UNASSIGNED: Of the collected samples, 1,833 (17.94%) tested positive for anti-pertussis IgG, with the median concentration of 16.06 IU/mL. Antibody level < 10 IU/mL accounted for more than 60% in children under 4 years of age, but declined with age, whereas the percentages of the other three levels (10-40, 40-50, and ≥ 50 IU/mL) increased almost with age ( P < 0.001). Moreover, 7,924 samples were selected for anti-pertussis toxin IgG, of which 653 (8.24%) tested positive (≥ 40 IU/mL) with the median concentration of 5.89 IU/mL, and 204 participants (2.56%) had recent pertussis infection (≥ 100 IU/mL). Among the different age groups, the highest rates of positivity and recent infection were observed at 11-20 years of age, the lowest positivity rate at 5 years of age, and the lowest recent infection rate at 4 years of age ( P < 0.001, P = 0.005, respectively).
UNASSIGNED: The survey results showed that all age groups in Guangxi lacked immunity against pertussis, which was one of the main factors contributing to the resurgence of pertussis in 2018. In addition, the prevalence of pertussis is relatively high in Guangxi, and its incidence is seriously underestimated, especially in adolescents and adults.