背景:血管周围巨噬细胞(PVMs)在维持大脑的生理功能中起关键作用。PVMs的功能障碍正在成为大脑中各种疾病状况的重要机制。
方法:在这项工作中,我们分析了PVMs的最新研究进展,尤其是在大脑中,来自WebofScience(WoS)核心数据库,使用基于搜索词“血管周围巨噬细胞”和“血管周围巨噬细胞”的文献计量分析,时间为2021年10月27日。可视化和协作分析由Citespace(5.8R3mac)进行。
结果:我们发现了1997年至2021年之间在PVM领域发表的2384篇文章,选择进行分析。PVM涉及多个生理病理领域,其中神经科学和神经病学,神经科学,免疫学,病理学,心血管系统和心脏病学报道最多。本研究主要集中在中枢神经系统(CNS)的PVMs,炎症,巨噬细胞或T细胞,和疾病,并重点介绍了有关其激活的相关基础研究,氧化应激,血管紧张素II,和胰岛素抵抗。肿瘤相关巨噬细胞,肥胖,骨髓细胞,炎症是最近的重点关键词,近年来引起了越来越多的关注。哈佛大学,阿姆斯特丹自由大学,在PVMs的研究领域中占有重要地位,同时,中国的PVM研究(北京大学,中山大学,上海交通大学,山东大学)正在崛起。聚类共引分析表明,中枢神经系统PVMs和相关脑疾病的机制是与PVMs相关的主要特征,而血管周围脂肪组织中的PVMs和血管疾病或肥胖是PVMs的另一大类热点。
结论:结论:对PVMs的研究不断深入,热点在不断变化。PVM的未来研究可能会有多个学科交叉。
Perivascular macrophages (PVMs) play pivotal roles in maintaining the physiological function of the brain. Dysfunction of PVMs is emerging as an important mechanism in various disease conditions in the brain.
In this work, we analyzed recent research advances in PVMs, especially in the brain, from the Web of Science (WoS) core database using bibliometric analysis based on the search terms \"perivascular macrophages\" and \"perivascular macrophage\" on October 27, 2021. Visualization and collaboration analysis were performed by Citespace (5.8 R3 mac).
We found 2384 articles published between 1997 and 2021 in the field of PVMs, which were selected for analysis. PVMs were involved in several physio-pathological fields, in which Neurosciences and Neurology, Neuroscience, Immunology, Pathology, and Cardiovascular System and Cardiology were most reported. The research focuses on PVMs mainly in the central nervous system (CNS), inflammation, macrophage or T-cell, and disease, and highlights the related basic research regarding its activation, oxidative stress, angiotensin II, and insulin resistance. Tumor-associated macrophage, obesity, myeloid cell, and inflammation were relatively recent highlight keywords that attracted increasing attention in recent years. Harvard Univ, Vrije Univ Amsterdam, occupied important positions in the research field of PVMs. Meanwhile, PVM research in China (Peking Univ, Sun Yat Sen Univ, Shanghai Jiao Tong Univ, and Shandong Univ) is on the rise. Cluster co-citation analysis revealed that the mechanisms of CNS PVMs and related brain diseases are major specialties associated with PVMs, while PVMs in perivascular adipose tissue and vascular diseases or obesity are another big category of PVMs hotspots.
In conclusion, the research on PVMs continues to deepen, and the hotspots are constantly changing. Future studies of PVMs could have multiple disciplines intersecting.