■在粘膜类天疱疮伴牙龈表达(gMMP)的情况下,尽管经过医学治疗,牙龈的完全愈合通常无法实现。因此,患者口腔舒适度受损。牙周微生物失调,由于缺乏与持续牙龈疼痛相关的口腔卫生,免疫病理机制能否持续存在。这项研究的主要目的是表征gMMP患者的龈下微生物群,并强调微生物数据和临床数据之间的潜在联系。
■收集15例gMMP患者的龈下生物膜,是否接受药物治疗,但没有接受牙周治疗.记录通常的临床牙周参数。通过聚合酶链反应定量分析生物膜。使用卡方或Fischer精确检验评估严重糜烂性牙龈炎和严重牙周炎的危险因素。
■无论患者的医疗和牙周状况如何,结果显示存在三个主要的牙周病群落,消生菌.第一个包括连翘单纳菌,微生物肽链球菌,具核梭杆菌,和直肌弯曲杆菌,在100%的患者中发现,第二个富含Dinticola密螺旋体60%,第三个富含牙龈卟啉单胞菌和中间Prevotella26%。此外,gMMP的持续时间与糜烂性牙龈炎的严重程度之间存在显着正相关(p=0.009),和深牙周组织的损失(p=0.04)。
■这项初步研究表明gMMP患者牙周风险较高。病理过程,一方面是自身免疫,另一方面是斑块诱导,可以互相放大。因此,牙周治疗的应用与医学治疗并行是必要的。然而,需要进一步的对照研究来验证和补充这些初步结果.
UNASSIGNED: In the case of mucous membrane pemphigoid with gingival expression (gMMP), the complete healing of the gingiva is generally not achieved despite medical treatment. Therefore, patients\' oral comfort is impaired. The dysbiotic periodontal microbiota, generated by a lack of oral hygiene associated with persistent gingival pain, could the immunopathological mechanism to persist. The main objective of this study was to characterize the subgingival microbiota of the gMMP patients, and to highlight a potential link between this microbiological data and the clinical data.
UNASSIGNED: Subgingival biofilm was collected from 15 gMMP patients, medically treated or not, but not receiving periodontal treatment. The usual clinical periodontal parameters were recorded. The biofilm was analyzed by polymerase chain reaction quantitative. The risk factors of severe erosive gingivitis and severe periodontitis were assessed using Chi-square or Fischer\'s exact test were used.
UNASSIGNED: Whatever the medical and periodontal conditions of the patients, the results showed the existence of three main communities of periodontopathic, dysbiotic bacteria. The first including Tannnerella forsythia, Peptostreptococcus micros, Fusobacterium nucleatum, and Campylobacter rectus, was found in 100% of the patients, the second enriched with Treponema denticola in 60% and the third enriched with Porphyromonas gingivalis and Prevotella intermedia in 26%. Furthermore, there was a significant positive link between the duration of gMMP and the severity of erosive gingivitis (p = 0.009), and the loss of deep periodontal tissue (p = 0.04).
UNASSIGNED: This pilot study suggests a high periodontal risk in gMMP patients. The pathological processes, autoimmune on the one hand and plaque-induced on the other, may amplify each other. The application of periodontal therapy is therefore necessary in parallel with medical treatment. Nevertheless, further controlled studies are required to validate and complement these preliminary results.