目的:研究表明类风湿性关节炎(RA)患者可以从牙周治疗中获益。然而,公布的数据不一致,需要更好的控制研究。我们的研究旨在解决这些局限性。
方法:在这项探索性随机延迟开始研究中,对22例中度/重度牙周炎的RA患者进行全口清创。牙周和风湿病评估,包括测量抗环瓜氨酸肽2(CCP2)IgG水平,在基线(V1)进行,第1步和第2步牙周治疗后2个月(V2)和6个月(V3)。主要结果是V2和V1之间的28个关节(DAS28)的疾病活动评分变化。次要结果是其他风湿病或牙周临床参数(V2或V3-V1)的变化。
结果:在基线时,重度牙周炎的RA患者的RA疾病活动度明显高于中度牙周炎,几个风湿病和牙周参数之间存在显著正相关。牙周治疗后,严重的RA患者,但不是温和的,牙周炎显示DAS28显着改善(ΔV2-V1,p=0.042;ΔV3-V1,p=0.001),V3时抗CCP2IgG水平显着降低(p=0.032)。
结论:牙周治疗对RA患者局部有效,并影响重度牙周炎患者的RA疾病活动和抗CCP2抗体水平。因此,我们的数据表明,在RA患者的治疗治疗中,牙周评估和治疗应纳入目标治疗策略.
背景:www.isrctn.com,ISRCTN17950307。
OBJECTIVE: Studies suggest rheumatoid arthritis (RA) patients could benefit from periodontal treatment. However, published data are inconsistent, and there is a need for better-controlled research. Our study aims to address these limitations.
METHODS: In this exploratory randomised delayed-start study, 22 RA patients with moderate/severe periodontitis were subjected to full-mouth debridement. Periodontal and rheumatological assessments, including measuring anti-cyclic citrullinated peptide 2 (CCP2) IgG levels, were performed at baseline (V1), 2 months (V2) and 6 months (V3) after step 1 and 2 of periodontal therapy. Primary outcome was changes in disease activity score for 28 joints (DAS28) between V2 and V1. Secondary outcomes were changes in other rheumatological or periodontal clinical parameters (V2 or V3-V1).
RESULTS: RA disease activity was significantly higher in RA patients with severe periodontitis compared to moderate periodontitis at baseline, with significant positive correlations between several rheumatological and periodontal parameters. After periodontal treatment, RA patients with severe, but not moderate, periodontitis demonstrated significant improvements in DAS28 (ΔV2-V1, p = 0.042; ΔV3-V1, p = 0.001) and significant reduction in anti-CCP2 IgG levels at V3 (p = 0.032).
CONCLUSIONS: Periodontal treatment is locally effective in patients with RA and impacts RA disease activity and anti-CCP2 antibody levels in patients with severe periodontitis. Hence, our data suggest that periodontal assessment and treatment should be integrated in the management of RA patients within a treat-to-target strategy.
BACKGROUND: www.isrctn.com, ISRCTN 17950307.