Perinatology

围产期学
  • 文章类型: Journal Article
    目的:我们的目的是探讨最近一次死产事件后女性的生活经历和需求。
    方法:定性现象学研究。
    方法:本研究于2024年1月25日至2024年3月29日在华东某三级产科医院进行。
    方法:14名在过去6个月内经历过死产的妇女。
    结果:研究人员在四个关键主题上达成了一致,包括情绪反应和恢复的个体差异,身体恢复和对未来怀孕的担忧,社会支持系统的关键作用和对死产的认识变化是胎儿与人类的死亡,以及相关的哀悼仪式。这些主题共同突出了死产经历的多面性,强调个人之间复杂的相互作用,塑造女性情感和身体反应的文化和医学因素。
    结论:中国女性的死产经历非常个性化,并受到个人情绪复杂相互作用的影响,文化背景和医学互动。医疗保健系统必须在标准协议之外实施量身定制的护理策略,以通过增强对文化敏感性的认识来主动解决其各种情感景观和身体问题。应设计针对医疗保健提供者的专业培训,以识别和应对独特的悲伤过程。应建立全面的支持系统,通过提供基本资源和社区联系,大大加快恢复进程。
    OBJECTIVE: We aimed to explore the lived experiences and needs of women after a recent stillbirth event.
    METHODS: Qualitative phenomenological study.
    METHODS: The current study was conducted in a tertiary obstetric hospital in East China between 25 January 2024 and 29 March 2024.
    METHODS: 14 women having experienced a stillbirth within the last 6 months.
    RESULTS: Researchers agreed on four key themes including individual variations in emotional reaction and recovery, physical recovery and concerns about future pregnancies, the critical role of social support systems and variations in perceptions of stillbirth as the death of a fetus versus a human being, along with related mourning rituals. These themes collectively highlight the multifaceted nature of the stillbirth experience, underscoring the complex interplay between personal, cultural and medical factors that shape women\'s emotional and physical responses.
    CONCLUSIONS: Post-stillbirth experiences among Chinese women are deeply individualised and influenced by a complex interplay of personal emotions, cultural contexts and medical interactions. It is imperative for healthcare systems to implement tailored care strategies beyond standard protocols to proactively address their varied emotional landscapes and physical concerns with an enhanced awareness of cultural sensitivities. Specialised training for healthcare providers should be devised to recognise and respond to the unique grief processes. Comprehensive support systems should be established to significantly enhance the recovery journey by providing essential resources and community connections.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    子宫内膜异位症是不孕的主要原因之一,由于对卵泡形成和子宫内膜容受性的负面影响。文献显示,子宫内膜异位症可能与围产期并发症有关,例如早产(PTB)和先兆子痫(PE)。作者假设,通过辅助生殖技术(ART)治疗构思的子宫内膜异位症相关不孕症的女性胎盘疾病的频率更高。主要结果是通过ART治疗构思的子宫内膜异位症妇女的单胎妊娠中足月胎盘的组织病理学改变的发生。与通过ART构思的男性因素(MF)引起的不育症的健康女性和自发怀孕的健康女性相比。次要结果包括围产期并发症的发生以及子宫内膜异位症与胎盘组织病理学特征的关系。
    单中心,在大学医院中心妇产科(UHC)内收集并在同一医院病理科进行分析的足月胎盘病例对照研究,一位高级围产期病理学家。使用阿姆斯特丹胎盘研讨会小组共识报告了组织病理学分析。所有注意到的胎盘病变分为以下几类:解剖,炎症,绒毛成熟和血管灌注不良。所需样本量为80个胎盘,研究结果用描述符报告,用卡方分析,费舍尔精确检验和克鲁斯卡尔-沃利斯方差分析。在校正混杂因素的情况下进行多因素回归分析。道德批准:第520-03/24-01/83类。
    研究包括107名女性的足月胎盘,其中36位是通过ART构思的子宫内膜异位症妇女,31例接受ART治疗的MF不孕健康女性和40例自发妊娠健康女性。子宫内膜异位症妇女主要是初产妇,不孕持续时间较长。子宫内膜异位症组妊娠早期出血和即将早产的发生率较高。子宫内膜异位症和MF组的Cesarian分娩(CS)发生率更高,而子宫内膜异位症组的新生儿出生体重最低。子宫内膜异位症组胎盘索(PC)较短,合胞体打结和血管灌注不良疾病的发生率更高(绒毛膜下和绒毛膜下纤维蛋白,绒毛间血栓形成,高级别胎儿血管灌注不良)。最后,子宫内膜异位症显示与合胞结形成增加和PC过度卷曲有关,在多元回归分析中对混杂因素进行调整后。
    尽管围产期并发症发生率低,我们报道子宫内膜异位症有更高的合胞体打结和血管灌注不良胎盘疾病的发生率,与对照组相比。子宫内膜异位症还与合胞体打结和PC过度卷曲增加有关。需要进一步的研究来阐明子宫内膜异位症对胎盘疾病和围产期并发症中子宫内膜容受性和免疫发病机制的影响。要点子宫内膜异位症女性主要是初产妇,不孕持续时间较长。子宫内膜异位症组妊娠早期出血和即将早产的发生率较高。此外,子宫内膜异位症和MF组的Cesarian分娩发生率较高,而子宫内膜异位症组的新生儿出生体重最低。子宫内膜异位症组有较短的胎盘索,合胞体打结和血管灌注不良病变的发生率更高。子宫内膜异位症显示与合胞结形成增加和胎盘索过度卷曲有关。在对混杂因素进行调整后。
    UNASSIGNED: Endometriosis is one of the leading causes of infertility, due to negative impact on ovarian folliculogenesis and endometrial receptivity. Literature show that endometriosis could be associated with perinatal complications such as preterm birth (PTB) and preeclampsia (PE). Authors hypothesized that women with endometriosis-related infertility conceived by assisted reproductive technology (ART) treatment have higher frequency of placental disorders. Main outcome is the occurrence of histopathologic alterations of term placentas in singleton pregnancies of women with endometriosis conceived by ART treatment, compared to healthy women with infertility due to male factor (MF) conceived by ART and to healthy women with spontaneous pregnancies. Secondary outcome include the occurrence of perinatal complications and the relationship of endometriosis and placental histopathologic characteristics.
    UNASSIGNED: Single-center, case-control study of term placentas that were collected within Department of Obstetrics and Gynecology of University Hospital Center (UHC) Split and analyzed in the Pathology department of the same hospital, by one senior perinatal pathologist. Histopathologic analysis was reported using Amsterdam Placental Workshop Group Consensus. All the noted placental lesions were divided into following categories: anatomic, inflammatory, villous maturation and vascular malperfusion disorders. Required sample size was 80 placentas, and study results were reported with descriptives, and analyzed with chi-squared, Fisher\'s exact test and Kruskal-Wallis ANOVA. Multivariate regression analysis was carried with adjustment for confounding factors. Ethics approval: Class n. 520-03/24-01/83.
    UNASSIGNED: Study included term placentas of 107 women, of which 36 were women with endometriosis conceived by ART, 31 were healthy women with MF infertility conceived by ART and 40 healthy women with spontaneous pregnancies. Endometriosis women were predominantly primiparas, with longer infertility duration. Endometriosis group had higher occurrence of early pregnancy bleeding and imminent preterm labor. Endometriosis and MF groups had higher occurrence of Cesarian delivery (CS), while endometriosis group had newborns with lowest birthweight. Endometriosis group had shorter placental cords (PC), higher rates of increased syncytial knotting and vascular malperfusion disorders (subchorionic and perivillous fibrin, intervillous thrombosis, high grade fetal vascular malperfusion). Finally, endometriosis is showed to be associated with increased syncytial knots\' formation and PC hypercoiling, after adjustment for confounding factors in the multivariate regression analysis.
    UNASSIGNED: Despite low rates of perinatal complications, we report endometriosis to have higher occurrence of increased syncytial knotting and vascular malperfusion placental disorders, compared to control groups. Endometriosis is also associated with increased syncytial knotting and PC hypercoiling. Further studies are needed to elucidate the endometriosis impact on endometrial receptivity and immunopathogenesis in placental disorders and perinatal complications.HighlightsEndometriosis women were predominantly primiparas, with longer infertility duration.Endometriosis group had higher occurrence of early pregnancy bleeding and imminent preterm labor. Moreover, endometriosis and MF groups had higher occurrence of Cesarian delivery, while endometriosis group had newborns with lowest birthweight.Endometriosis group had shorter placental cords, higher rates of increased syncytial knotting and vascular malperfusion lesions.Endometriosis is showed to be associated with increased syncytial knots formation and hypercoiling of placental cord, after adjustment for confounding factor.
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  • 文章类型: Journal Article
    目的:本研究旨在评估影响孕妇参与围产期教育的因素及其对教育课程的需求。
    方法:横断面研究。
    方法:苏州市三级医院,中国,2022年7月-9月。
    方法:通过在线调查邀请,招募苏州某三级甲等综合医院指定时间段内的孕妇。
    方法:使用自行设计的量表评估孕妇对围产期教育的需求。使用多个响应集评估多项选择项,分析包括频率和交叉列表。采用Logistic回归分析评价影响孕妇参与围产期教育的因素。
    结果:测量的主要结果是孕妇对围产期教育的需求。
    结果:大多数(53.8%)的孕妇表示偏爱在线和离线形式相结合的混合教学模式。Logistic回归分析显示,受教育程度显著影响孕妇参与在线学习。具体来说,受教育程度较高的女性更有可能积极参与在线课程。此外,与那些有第一个孩子的人相比,有第二个孩子的孕妇参与在线学习的积极性较低。与前三个月的孕妇相比,第二和第三三个月的孕妇对在线学习的参与度更高。
    结论:这些发现表明,中国孕妇对围产期教育的偏好受其教育背景的影响,妊娠史和采用的教学模式。教育需求的可变性强调了根据参与者的反馈定期更新课程内容的重要性。
    OBJECTIVE: This study aimed to assess the factors influencing pregnant women\'s participation in perinatal education and their demand for educational courses.
    METHODS: A cross-sectional study.
    METHODS: Tertiary hospital in Suzhou, China, July-September 2022.
    METHODS: Pregnant women from a general grade A tertiary hospital in Suzhou were recruited via online survey invitations during the specified period.
    METHODS: A self-designed scale was used to evaluate pregnant women\'s demand for perinatal education. Multiple response sets were employed for the assessment of multiple-choice items and analyses included frequency and cross-tabulation. Logistic regression analysis was conducted to assess the factors influencing pregnant women\'s participation in perinatal education.
    RESULTS: The primary outcome measured was the demand for perinatal education among pregnant women.
    RESULTS: A majority (53.8%) of pregnant women expressed a preference for a mixed teaching mode combining online and offline formats. Logistic regression analysis showed that education level significantly influenced pregnant women\'s participation in online learning. Specifically, women with higher education levels were more likely to participate actively in online courses. Additionally, compared with those with first-born children, pregnant women with second-born children participated less actively in online learning. Pregnant women in their second and third trimesters showed greater engagement in online learning compared with those in their first trimester.
    CONCLUSIONS: These findings indicate that Chinese pregnant women\'s preferences for perinatal education are influenced by their educational background, pregnancy history and the mode of teaching employed. The variability in educational needs underscores the importance of regularly updating course content based on participant feedback.
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  • 文章类型: Journal Article
    目的:定义并发展一套委托专业活动(EPA),将临床培训与新生儿科住院医师计划中新生儿护理医院组成部分的评估联系起来。
    方法:使用改良的Delphi方法分两个阶段进行了一项探索性研究。在第一阶段,一个由五名新生儿科住院医师计划协调员组成的委员会根据国家能力矩阵和国际组织定义的EPA起草了一套初步的EPA。在第二阶段,一组新生儿护理医师和住院医师对EPA的必要性和清晰度进行了评价,并提出了意见和建议.
    结果:七个EPA由协调员委员会(n=5)起草,并用于一组(n=37)新生儿护理医师和医疗居民的内容验证过程。在第一轮Delphi中,所有EPA的内容效度指数(CVI)均高于0.8。协调员委员会分析了意见和建议,并修订了EPA。对修订后的EPA进行了第二轮Delphi验证,所有项目的CVI均保持在0.8以上,以确保不可或缺性和清晰度。
    结论:开展了7项委托专业活动,以评估住院居民的新生儿护理医学组成部分。这些EPA可能有助于实施以核心专业活动为基础的基于能力的新生儿医学住院医师计划。
    OBJECTIVE: Define and develop a set of entrustable professional activities (EPAs) to link clinical training and assessment of the hospital components of neonatal care in neonatology medical residency programs.
    METHODS: An exploratory study was conducted in two phases using a modified Delphi approach. In the first phase, a committee of five neonatology residency program coordinators drafted an initial set of EPAs based on the national matrix of competencies and on EPAs defined by international organizations. In the second phase, a group of neonatal care physicians and medical residents rated the indispensability and clarity of the EPAs and provided comments and suggestions.
    RESULTS: Seven EPAs were drafted by the coordinators´ committee (n = 5) and used in the content validation process with a group (n = 37) of neonatal care physicians and medical residents. In the first Delphi round, all EPAs reached a content validity index (CVI) above 0.8. The coordinators´ committee analyzed comments and suggestions and revised the EPAs. A second Delphi round with the revised EPAs was conducted to validate and all items maintained a CVI above 0.8 for indispensability and clarity.
    CONCLUSIONS: Seven entrustable professional activities were developed to assess residents in the hospital components of neonatal care medicine. These EPAs might contribute to implementing competency-based neonatology medical residency programs grounded in core professional activities.
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  • 文章类型: Journal Article
    背景:全球,孩子们,新生儿,孕妇或产后妇女容易受到灾害和紧急情况的影响,向这些人口提供支持是非常令人关注的。日本地处灾害多发地区,因此,救灾和减少风险战略是重要的优先事项。
    方法:我们介绍了一种称为儿科和围产期医学灾难联络(DLPPM)的系统。这是专门针对日本围产期儿童和孕妇而创建的。我们报告其活动的细节,讨论它的挑战,并吸取进一步发展围产期支持系统的经验教训,特别是对于儿童。
    结果:从DLPPM活动中吸取的经验教训包括:(1)为儿科和围产期专科以外的急诊专家建立支持系统;(2)减轻由主要灾害造成的间接损害的风险;(3)建立与现有儿科和围产期医学设施相关的网络功能。
    结论:通过建立类似的系统,我们认为,在全球其他国家和地区的灾难应对背景下,解决儿科和围产期护理需求将是可行的。
    BACKGROUND: Worldwide, children, newborns, and pregnant or postpartum women are vulnerable to disasters and emergency situations, and providing support to this population is of great concern. Japan is located in a disaster-prone area, so disaster response and risk reduction strategies are important priorities.
    METHODS: We introduce a system called the Disaster Liaison for Pediatric and Perinatal Medicine (DLPPM). This was created with a specific focus on perinatal children and pregnant women in Japan. We report the details of its activities, discuss its challenges, and draw on lessons learned for the further development of perinatal support systems, particularly for children.
    RESULTS: The lessons learned from the activities of the DLPPM include the following: (1) establish a support system for emergency specialists beyond those with pediatric and perinatal specialties; (2) mitigate the risk of indirect damage caused by primary disasters; and (3) establish a networking function linked to existing pediatric and perinatal medicine facilities.
    CONCLUSIONS: By establishing similar systems, we believe that it will be feasible to address pediatric and perinatal care needs in disaster response contexts in other countries and regions around the world.
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  • 文章类型: Journal Article
    大多数儿科研究金的持续时间为三年。随着一些门诊儿科专科医生短缺的增加,对于对基于研究的职业不感兴趣的临床定向学员,正在考虑较短的两年奖学金。缩短研究金的期限可能会带来一些经济上的好处,例如在较短的培训后更早获得更高的薪水。然而,我们认为,由于住院期间重症监护轮换的减少,在这个时候,继续进行三年的新生儿学治疗更为务实,实现程序卓越所需的时间,需要接触质量保证方法,熟练掌握床边超声等新技术,并维持医生-科学家的管道。对新生儿研究金的需求仍然很高。对就业市场的持续评估,需要培训需求和研究金课程,以确定将来是否应更改研究金的期限。
    The duration of the majority of fellowships in pediatrics has been three-years. With increasing shortages of some outpatient-based pediatric subspecialists, shorter two-year fellowships are being considered for clinically oriented trainees not interested in a career based on research. Shortening the duration of fellowship may have some financial merits such as achieving a higher salary earlier after shorter training. However, we feel that continuing with a three-year duration for neonatology is more pragmatic at this time due to reductions in intensive care rotations during residency, time required to  achieve procedural excellence, the need for exposure to quality assurance methodology, proficiency in novel techniques such as bedside ultrasound, and to maintain the physician-scientist pipeline. The demand for neonatal fellowship continues to be high. Ongoing evaluation of the job market, training needs and fellowship curriculum is needed to determine if the duration of fellowship should be altered in the future.
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  • 文章类型: Journal Article
    背景:尚未描述为学员准备求职的标准化方法。这项研究的目的是描述和评估有关新生儿围产期医学(NPM)研究员的求职教育系列,并确定参与者的求职知识差距。
    方法:在2020-2021学年,我们创造了一个虚拟的,不需要资金的NPM研究员的七部分求职系列。该系列每年都会重复。我们使用REDCap调查来登记参与者,收集基线/人口统计信息,并在求职时间表的开始和结束时评估系列\'影响。
    结果:在2021-2022学年,290人注册了该系列,89%完成了基线/人口调查。大多数是NPM研究员(89%)。早期职业新生儿学家,NPM住院医生,儿科居民也使用了该系列(11%)。不到25%的人报告核心求职成分“知识渊博”或“知识渊博”,包括找工作的时间线,合同谈判,以及初级教师的一般角色和职责。在完成最终求职调查并进行求职的人中(60%,162的97)大多数(86%)认为培训期间的职业规划压力很大,并认为求职准备应纳入NPM研究金课程(81%)。许多人认为求职系列有助于阐明求职的组成部分。
    结论:我们在NPM研究员中发现了一些知识空白,准备,和谈判他们的第一份培训后工作。我们坚信,这些知识差距并不是NPM研究员所独有的,所有研究生医学教育学员都将受益于类似的,易于实现,无成本系列。
    BACKGROUND: A standardized approach to prepare trainees for the job search has not been described. The objective of this study was to describe and evaluate an educational series on the job search for Neonatal-Perinatal Medicine (NPM) fellows and identify participants\' job search knowledge gaps.
    METHODS: During the 2020-2021 academic year, we created a virtual, seven-part job search series for NPM fellows that required no funding. The series has been repeated annually. We use REDCap surveys to register participants, collect baseline/demographic information, and evaluate the series\' impact at the beginning and end of the job search timeline.
    RESULTS: In the 2021-2022 academic year, 290 individuals registered for the series, and 89% completed the baseline/demographic survey. The majority were NPM fellows (89%). Early career neonatologists, NPM hospitalists, and pediatric residents also utilized the series (11%). Less than 25% reported being \"knowledgeable\" or \"very knowledgeable\" of core job search components, including the timeline of the job search, contract negotiation, and the general roles and responsibilities of junior faculty. Of those who completed the final job search survey and underwent a job search (60%, 97 of 162), the majority (86%) felt that career planning during training was stressful and believed that job search preparation should be structured into the NPM fellowship curriculum (81%). Many felt that the Job Search Series was helpful in elucidating components of the job search.
    CONCLUSIONS: We identified several knowledge gaps in NPM fellows\' understanding of how to find, prepare for, and negotiate their first post-training job. We strongly believe these knowledge gaps are not unique to NPM fellows and that all graduate medical education trainees would benefit from a similar, easy-to-implement, no-cost series.
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  • 文章类型: Journal Article
    目的:这项研究调查了III/IV级新生儿重症监护病房(NICU)和II级新生儿科住院时间(LoS)的变化,直至早产婴儿出院回家,并确定了影响这些趋势的因素。
    方法:回顾性队列研究基于2008年至2021年荷兰围产期注册记录的数据。
    方法:荷兰的单一III/IV级NICU和多个II级新生儿科。
    方法:NICU住院婴儿(n=2646),胎龄(GA)<32周。
    方法:NICU的LoS和整体LoS直到出院回家。
    结果:结果显示,在考虑混杂变量后,第3期的总LoS增加了5.1天(95%CI2.2至8,p<0.001)。这一增长主要是由于二级医院扩大了LoS,而NICU的LoS保持稳定。该研究还表明,早产的严重并发症与LoS之间存在很强的关联。在最近的时期内,对具有较低GA和更多(严重)并发症(如早产儿严重视网膜病变)的婴儿的治疗可能会增加LoS。
    结论:这项研究的结果强调了早产儿总体LoS的增加。极早产儿的LoS可能受早产并发症发生的影响,在胎龄较低的婴儿中更常见。
    OBJECTIVE: This study investigated changes in the length of stay (LoS) at a level III/IV neonatal intensive care unit (NICU) and level II neonatology departments until discharge home for very preterm infants and identified factors influencing these trends.
    METHODS: Retrospective cohort study based on data recorded in the Netherlands Perinatal Registry between 2008 and 2021.
    METHODS: A single level III/IV NICU and multiple level II neonatology departments in the Netherlands.
    METHODS: NICU-admitted infants (n=2646) with a gestational age (GA) <32 weeks.
    METHODS: LoS at the NICU and overall LoS until discharge home.
    RESULTS: The results showed an increase of 5.1 days (95% CI 2.2 to 8, p<0.001) in overall LoS in period 3 after accounting for confounding variables. This increase was primarily driven by extended LoS at level II hospitals, while LoS at the NICU remained stable. The study also indicated a strong association between severe complications of preterm birth and LoS. Treatment of infants with a lower GA and more (severe) complications (such as severe retinopathy of prematurity) during the more recent periods may have increased LoS.
    CONCLUSIONS: The findings of this study highlight the increasing overall LoS for very preterm infants. LoS of very preterm infants is presumably influenced by the occurrence of complications of preterm birth, which are more frequent in infants at a lower gestational age.
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  • 文章类型: Journal Article
    背景:由于患者的复杂性增加,新生儿-围产期医学(NPM)研究金培训中的新生儿心血管护理主题一直在不断转变,专业化单位的发展,继续认证委员会对研究生医学教育的要求,以及护理先天性心脏病(CHD)新生儿的中心之间的临床实践差异。
    方法:我们开发了一个新生儿心脏课程,该课程由八个互动课程组成,其中包含针对NPM研究员的新颖主动学习概念。在基线和完成课程后,所有新生儿科研究员都对CHD婴儿的舒适度和新生儿心脏病学主题的感知能力进行了自我评估调查。将美国儿科学委员会的子专业培训考试(SITE)分数与全国平均水平进行了比较。
    结果:第一年研究员的平均舒适度得分(0-100)从33增加到76,第二年和第三年研究员的平均舒适度得分分别从72增加到86和75增加到86。第一年研究员将他们的能力得分提高了44分(3个标准差),二年级研究员的分数提高了约26分(一个标准差),所有研究员的能力得分总体上增加了9分(一个标准差)。在启动本课程之前,当地网站的平均成绩低于全国平均水平,在课程实施的第一年结束时,成绩几乎等于全国平均分,从那以后逐渐变得更高。
    结论:由于不同的临床暴露和不同的CHD管理实践模式,新生儿心脏课程可能对NPM学员有益。
    BACKGROUND: The topic of neonatal cardiovascular care in neonatal-perinatal medicine (NPM) fellowship training has continued to transform due to increased complexity of patients, development of specialized units, continued Accreditation Council for Graduate Medical Education requirements, and clinical practice variation across centers that care for neonates with congenital heart disease (CHD).
    METHODS: We developed a neonatal cardiac curriculum comprised of eight interactive sessions with novel active learning concepts specific to our NPM fellows. A self-assessment survey in comfort in managing infants with CHD and perceived competency in neonatal cardiology topics was performed by all neonatology fellows at baseline and after completion of the curriculum. The American Board of Pediatrics Subspecialty In-training Exam (SITE) scores for fellows were compared to that of the national average.
    RESULTS: The average comfort score (0-100) of the first-year fellows increased from 33 to 76, and that of the second and third-year fellows increased from 72 to 86, and 75 to 86, respectively. The first-year fellows improved their competency score by 44 points (3 standard deviations), the second-year fellows improved their score by about 26 points (one standard deviation), and there was an overall 9-point increase in the competency score of all fellows (one standard deviation). The average local SITE score was lower than the national average before the initiation of this curriculum, became nearly equal to the national average score at the end of the first year the curriculum was implemented, and has progressively become higher since then.
    CONCLUSIONS: Due to the variable clinical exposure and differing practice models of managing CHD a neonatal cardiac curriculum may be beneficial to NPM trainees.
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