背景:人口不断老龄化,大多数老年人随着年龄的增长会经历许多潜在的生理变化,导致功能下降。泌尿和肠道功能障碍是老年人最常见的障碍。目前,与衰老相关的盆底组织学变化的分析尚未完全阐明,改善老年人肠道控制能力的机制尚不清楚。
目的:这项研究的目的是描述如何使用有限元方法来了解康复过程中盆腔的力学特性和生理变化,为改善老年人排尿排便功能障碍的机制提供理论支持。
方法:我们将收集一名男性和一名60岁以上女性志愿者的盆腔磁共振成像(MRI)和计算机断层扫描(CT)数据,并使用有限元方法构建盆腔的3D计算机模拟模型。通过模拟不同的生理状态,比如Valsalva动作和排便,我们将验证所构建模型的准确性,研究不同神经肌肉功能变化的影响,并量化盆底肌肉群的影响比例,核心肌肉群,和骶神经.
结果:目前,我们在中国临床试验注册中心登记了这项研究,并收集了1例老年男性和1例老年女性患者的MRI和CT数据.接下来,有限元模型的构建和分析将根据研究计划完成。我们预计在2024年7月前完成有限元模型的构建和分析,并在2025年10月前公布研究成果。
结论:我们的研究将建立老年男性和老年女性盆底的有限元模型,我们将阐明盆底肌肉之间的关系,回来,腹部,和臀部以及老年人控制排便的能力。本研究结果将为阐明通过康复改善排尿排便功能障碍的机制提供理论支持。
背景:中国临床试验注册ChiCTR2400080749;https://www.chictr.org.cn/showproj.html?proj=193428。
■DERR1-10.2196/56333。
BACKGROUND: The population is constantly aging, and most older adults will experience many potential physiological changes as they age, leading to functional decline. Urinary and bowel dysfunction is the most common obstacle in older people. At present, the analysis of pelvic floor histological changes related to aging has not been fully elucidated, and the mechanism of improving intestinal control ability in older people is still unclear.
OBJECTIVE: The purpose of this study is to describe how the finite element method will be used to understand the mechanical characteristics of and physiological changes in the pelvic cavity during the rehabilitation process, providing theoretical support for the mechanism for improving urination and defecation dysfunction in older individuals.
METHODS: We will collect magnetic resonance imaging (MRI) and computed tomography (CT) data of the pelvic cavity of one male and one female volunteer older than 60 years and use the finite element method to construct a 3D computer simulation model of the pelvic cavity. By simulating different physiological states, such as the Valsalva maneuver and bowel movement, we will verify the accuracy of the constructed model, investigate the effects of different neuromuscular functional changes, and quantify the impact proportions of the pelvic floor muscle group, core muscle group, and sacral nerve.
RESULTS: At present, we have registered the study in the Chinese Clinical Trial Registry and collected MRI and CT data for an older male and an older female patient. Next, the construction and analysis of the finite element model will be accomplished according to the study plan. We expect to complete the construction and analysis of the finite element model by July 2024 and publish the research results by October 2025.
CONCLUSIONS: Our study will build finite element models of the pelvic floor of older men and older women, and we shall elucidate the relationship between the muscles of the pelvic floor, back, abdomen, and hips and the ability of older adults to control bowel movements. The results of this study will provide theoretical support for elucidating the mechanism for improving urination and defecation dysfunction through rehabilitation.
BACKGROUND: Chinese Clinical Trial Registry ChiCTR2400080749; https://www.chictr.org.cn/showproj.html?proj=193428.
UNASSIGNED: DERR1-10.2196/56333.