背景:尚无法估计COVID-19患者中出现明显经典神经系统症状和综合征的比例。这项研究的目的是估计感觉症状的发生率(感觉减退,感觉异常,和痛觉过敏)在马德里大学Alcorcón医院(HUFA)出现这种疾病的医生;建立感觉症状与其他感染迹象之间的关系;并研究它们与COVID-19严重程度的关系。
方法:我们进行了描述性的,横截面,回顾性,观察性研究。这项研究包括在2020年3月1日至7月25日期间出现SARS-CoV-2感染的HUFA医生。自愿的,匿名调查是通过公司电子邮件分发的。社会人口统计学和临床特征是从有PCR或血清学证实的COVID-19的专业人士那里收集的。
结果:调查已发送给801名医生,我们收到89份回复。受访者的平均年龄为38.28岁。共有17.98%出现感觉症状。发现感觉异常与咳嗽之间存在显着关系,发烧,肌痛,虚弱,和呼吸困难.由于COVID-19,感觉异常与治疗和入院的需要之间也存在显著关系。87.4%的病例从发病第5天开始出现感觉症状。
结论:SARS-CoV-2感染可能与感觉症状有关,主要是在严重的情况下。感觉症状通常在一段时间后出现,可能是由具有自身免疫背景的副感染综合征引起的。
BACKGROUND: It is not yet possible to estimate the proportion of patients with COVID-19 who present distinguishable classical neurological symptoms and syndromes. The objective of this study is to estimate the incidence of sensory symptoms (hypoaesthesia, paraesthesia, and hyperalgesia) in physicians who have presented the disease at Hospital Universitario Fundación Alcorcón (HUFA) in Madrid; to establish the relationship between sensory symptoms and the presence of other signs of infection; and to study their association with the severity of COVID-19.
METHODS: We conducted a descriptive, cross-sectional, retrospective, observational study. HUFA physicians who presented SARS-CoV-2 infection between 1 March and 25 July 2020 were included in the study. A voluntary, anonymous survey was distributed via corporate email. Sociodemographic and clinical characteristics were collected from professionals with PCR- or serology-confirmed COVID-19.
RESULTS: The survey was sent to 801 physicians and we received 89 responses. The mean age of respondents was 38.28 years. A total of 17.98% presented sensory symptoms. A significant relationship was found between the presence of paraesthesia and cough, fever, myalgia, asthaenia, and dyspnoea. A significant relationship was also found between paraesthesia and the need for treatment and admission due to COVID-19. Sensory symptoms were present from the fifth day of illness in 87.4% of cases.
CONCLUSIONS: SARS-CoV-2 infection can be associated with sensory symptoms, mostly in severe cases. Sensory symptoms often appear after a time interval, and may be caused by a parainfectious syndrome with an autoimmunity background.