目的:评估COVID-19疫苗接种后贝尔麻痹的合并发病率。
方法:PubMed,Scopus,EMBASE,WebofScience,谷歌学者被两名独立研究人员搜索。我们还搜索了灰色文献,包括参考文献和会议摘要的参考文献。我们提取了有关参与者总数的数据,第一作者,出版年份,原产国,女/男,疫苗的类型,以及接种COVID-19疫苗后出现贝尔麻痹的患者人数。
结果:文献检索显示370篇文章,随后删除重复227剩余。在仔细评估全文后,仍有20篇文章进行荟萃分析。最常用的疫苗是辉瑞,其次是Moderna。总的来说,4.54e+07人接种了COVID-19疫苗,1739例出现贝尔麻痹。在九项研究中,纳入对照组(未接种疫苗的个体).总人数为9018069人,其中,203发展为贝尔麻痹。COVID-19疫苗接种后贝尔麻痹的发生率可忽略不计。COVID-19疫苗接种后发生贝尔麻痹的几率为1.02(95CI:0.79-1.32)(I2=74.8%,p<0.001)。
结论:这项系统评价和荟萃分析的结果表明,接种COVID-19疫苗后周围性面神经麻痹的发生率是可以忽略的,接种疫苗不会增加发生贝尔氏麻痹的风险。也许,贝尔氏麻痹是一种更严重形式的COVID-19的表现症状,因此临床医生必须意识到这一点。
OBJECTIVE: To estimate the pooled incidence of Bell\'s palsy after COVID-19 vaccination.
METHODS: PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were searched by 2 independent researchers. We also searched the grey literature including references of the references and conference abstracts. We extracted data regarding the total number of participants, first author, publication year, the country of origin, sex, type of vaccines, and the number of patients who developed Bell\'s palsy after COVID-19 vaccination.
RESULTS: The literature search revealed 370 articles, subsequently deleting duplicates 227 remained. After careful evaluation of the full texts, 20 articles remained for meta-analysis. The most commonly administered vaccines were Pfizer followed by Moderna. In total, 4.54e+07 individuals received vaccines against COVID-19, and 1739 cases developed Bell\'s palsy. In nine studies, controls (individuals without vaccination) were enrolled. The total number of controls was 1 809 069, of whom 203 developed Bell\'s palsy. The incidence of Bell\'s palsy after COVID-19 vaccines was ignorable. The odds of developing Bell\'s palsy after COVID-19 vaccines was 1.02 (95% CI: 0.79-1.32) (I2 = 74.8%, P < .001).
CONCLUSIONS: The results of this systematic review and meta-analysis show that the incidence of peripheral facial palsy after COVID-19 vaccination is ignorable and vaccination does not increase the risk of developing Bell\'s palsy. Maybe, Bell\'s palsy is a presenting symptom of a more severe form of COVID-19, so clinicians must be aware of this.