对皮肤施加空间交错的无害的温暖和凉爽刺激会引起虚幻的疼痛,被称为热格栅错觉(TGI)。本研究旨在区分中枢和周围神经性疼痛的潜在机制,重点关注疼痛质量。这被认为表明疼痛的潜在机制。我们比较了中枢和周围神经性疼痛的疼痛质量,并参考了TGI引起的疼痛的疼痛质量。
实验1:137名健康参与者将他们的手放在八个定制的铜棒上60秒,他们的疼痛质量通过麦吉尔疼痛问卷进行评估。实验2:对患有中枢和周围神经性疼痛的患者进行疼痛质量评估(42例脊髓损伤患者,31例中风患者,三叉神经痛83例,带状疱疹后遗神经痛131例)。
实验1:使用主成分分析发现了TGI引起的疼痛的两个成分:成分1包括疼痛,跳动,沉重和燃烧的疼痛,成分2包括瘙痒,电击,麻木,和冷冻结。实验2:多重对应分析(MCA)和交叉列表分析揭示了特定的疼痛品质,包括疼痛,热燃烧,沉重,冷冻结,麻木,电击疼痛与中枢神经性疼痛相关,而不是周围神经性疼痛。
我们发现健康参与者中TGI诱发的疼痛与中枢神经性疼痛而非外周神经性疼痛之间具有相似的性质。TGI的机制更类似于中枢神经性疼痛的机制,而不是神经性疼痛的机制。
Application of spatially interlaced innocuous warm and cool stimuli to the skin elicits illusory pain, known as the thermal grill illusion (TGI). This study aimed to discriminate the underlying mechanisms of central and peripheral neuropathic pain focusing on pain quality, which is considered to indicate the underlying mechanism(s) of pain. We compared pain qualities in central and peripheral neuropathic pain with reference to pain qualities of TGI-induced pain.
Experiment 1:137 healthy participants placed their hand on eight custom-built copper bars for 60 s and their pain quality was assessed by the McGill Pain Questionnaire. Experiment 2: Pain quality was evaluated in patients suffering from central and peripheral neuropathic pain (42 patients with spinal cord injury, 31 patients with stroke, 83 patients with trigeminal neuralgia and 131 patients with postherpetic neuralgia).
Experiment 1: Two components of TGI-induced pain were found using principal component analysis: component 1 included aching, throbbing, heavy and burning pain, component 2 included itching, electrical-shock, numbness, and cold-freezing. Experiment 2: Multiple correspondence analysis (MCA) and cross tabulation analysis revealed specific pain qualities including aching, hot-burning, heavy, cold-freezing, numbness, and electrical-shock pain were associated with central neuropathic pain rather than peripheral neuropathic pain.
We found similar qualities between TGI-induced pain in healthy participants and central neuropathic pain rather than peripheral neuropathic pain. The mechanism of TGI is more similar to the mechanism of central neuropathic pain than that of neuropathic pain.