如今,传染病作为全球危机持续存在,对世界各国的公共卫生和经济稳定造成重大破坏。尤其是由于多药耐药性(MDR)的流行和出现以及现有治疗选择的局限性,细菌感染仍然是最严重的问题。抗菌光动力疗法(APDT)是一种潜在的治疗方式,涉及光敏剂(PS)的系统给药,光,和分子氧(O2)用于应对细菌感染。尽管现有的卟啉和非卟啉PS在APDT中有效,溶解性差,对革兰氏阴性细菌的疗效有限,和非特异性分布阻碍了它们的临床应用。因此,为了提高传统PS的效率,各种聚合物驱动的改性和功能化策略已被采用来设计多功能混合光疗。这篇综述评估了为APDT应用开发的聚合物-PSs混合材料的最新进展和最新研究。Further,以下方面的关键研究成果被认为是深入的建设性讨论:i)通过各种分子相互作用的PSs集成/功能化聚合物复合材料;ii)PSs沉积在不同基材和设备上的涂层,以消除与医疗保健相关的感染;iii)PSs嵌入膜,脚手架,和用于再生医学应用的水凝胶。
Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain a most severe concern due to the prevalence and emergence of multi-drug resistance (MDR) and limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is a potential therapeutic modality that involves the systematic administration of photosensitizers (PSs), light, and molecular oxygen (O2) for coping with bacterial infections. Although the existing porphyrin and non-porphyrin PSs were effective in APDT, the poor solubility, limited efficacy against Gram-negative bacteria, and non-specific distribution hinder their clinical applications. Accordingly, to promote the efficiency of conventional PSs, various polymer-driven modification and functionalization strategies have been adopted to engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements and state-of-the-art research in polymer-PSs hybrid materials developed for APDT applications. Further, the key research findings of the following aspects are considered in-depth with constructive discussions: i) PSs-integrated/functionalized polymeric composites through various molecular interactions; ii) PSs-deposited coatings on different substrates and devices to eliminate healthcare-associated infections; and iii) PSs-embedded films, scaffolds, and hydrogels for regenerative medicine applications.