UNASSIGNED:本系统综述和荟萃分析旨在评估针灸对肺癌成人患者报告结局(PRO)的影响。
UNASSIGNED:电子数据库,包括PubMed,Embase,科克伦图书馆,WebofScience,中国国家知识基础设施(CNKI),中国科技期刊数据库(CQVIP),万方数据,SinoMed,检索了从开始到2022年7月1日的灰色文献,用于随机对照试验(RCT)。针灸被定义为一种实验性干预,对照组的患者包括常规治疗(常规护理,假/安慰剂针灸,药物治疗,包括西药和中药)。本研究的PRO通过七个主要结局量表进行测量,包括Karnofsky表现状态(KPS),欧洲癌症研究和治疗组织生活质量问卷,癌症治疗的功能评估-肺,癌症治疗的功能评估肺癌子量表,莱斯特咳嗽问卷(LCQ评分),医疗结果研究(MOS)项目简称健康调查(SF-36),和圣乔治呼吸问卷,和12个次要结果量表。CochraneCollaboration的工具用于评估偏倚的风险。将数据与RevMan5.4和Stata/SE16.0进行组合和分析。
UASSIGNED:我们从33项试验中检索到3,002名肺癌患者。包括1,000名患者的KPS显示,与对照组相比,无论不同的肿瘤淋巴结转移阶段或疾病的不同阶段,针刺都可以显着提高生活质量(QOL)。研究表明,针刺显著改善肺癌相关症状的QOL,疼痛,恶心和呕吐,失眠,焦虑和抑郁,疲劳,便秘与对照组比较。八个RCT报告了不良事件的发生,而4例报告无事件发生,4例RCT报告观察组事件明显少于对照组.
未经授权:针灸被证明是一种有希望的干预措施,术后和化疗后,应推荐作为一种有益的替代策略,以在所有应用阶段的肺癌患者中推广PROs。考虑到低质量,我们建议在未来进行更严格的针灸治疗肺癌的临床试验,并更多地强调针灸对肺癌患者PROs的影响,主要是在QOL方面。
UNASSIGNED:https://www。crd.约克。AC.uk/prospro/display_record.php?,标识符[CRD42021274122]。
UNASSIGNED: This systematic review and meta-analysis aims to assess the effects of acupuncture on patient-reported outcomes (PROs) in adults with lung cancer.
UNASSIGNED: Electronic databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (CQVIP), Wanfang Data, SinoMed, and gray literatures were retrieved from inception to 1 July 2022 for randomized controlled trials (RCTs). Acupuncture was defined as an experimental intervention, and the patients of the control groups included either treatment including conventional therapy (usual care, sham/placebo acupuncture, pharmacotherapy including Western medicine and Chinese traditional medicine). PROs for this study were measured by seven scales of primary outcomes including the Karnofsky Performance Status (KPS), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Functional Assessment of Cancer Therapy-Lung, Functional Assessment of Cancer Therapy Lung Cancer Subscale, Leicester Cough Questionnaire (LCQ score), the Medical Outcomes Study (MOS) item short form health survey (SF-36), and the St George\'s Respiratory Questionnaire, and 12 scales of secondary outcomes. Cochrane Collaboration\'s tool was used to assess the risks of bias. Data were combined and analyzed with RevMan 5.4 and Stata/SE 16.0.
UNASSIGNED: We retrieved 3,002 lung cancer patients from 33 trials. KPS included with 1,000 patients showed that acupuncture could significantly improve the quality of life (QOL) compared with the control group regardless of different tumor-node-metastasis stages or the different stages of disease. The study showed that acupuncture significantly improved lung cancer-related symptoms in the QOL, pain, nausea and vomiting, insomnia, anxiety and depression, fatigue, and constipation compared with the control group. Eight RCTs reported the occurrence of adverse events, whereas four reported none and four RCTs reported that the events in the observation group were significantly less than those in the control group.
UNASSIGNED: Acupuncture proved to be a promising intervention, both postoperatively and after chemotherapy, and should be recommended as a beneficial alternative strategy to promote PROs in lung cancer patients at all stages of application. Considering the low quality, we suggest more rigorous clinical trials of acupuncture for lung cancer in the future and more emphasis on the effect of acupuncture in patients with lung cancer on their PROs, mainly in the aspect of the QOL.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?, identifier [CRD42021274122].