多模态磁共振成像(MRI),包括高分辨率结构成像,扩散张量成像(DTI),磁化转移比(MTR)成像,对计算机断层扫描阴性的轻度创伤性脑损伤(mTBI)患者和无伴随脑损伤的骨科损伤(OI)组进行了磁共振波谱成像(MRSI).OI组作为mTBI的比较组。在损伤的急性期(~24小时)和随访期(~90天)进行MRI扫描。使用基于道的空间统计(TBSS)分析DTI数据。使用基于张量的形态计量学(TBM)计算全球和区域萎缩。使用标准方法计算MTR值。使用LC模型分析MRSI。在初始扫描时,mTBI队列中包括内囊在内的多个白质(WM)区域的平均扩散率(MD)明显高于对照组,外囊,上电晕辐射,前日冕辐射,后日冕辐射,下额枕骨束,下纵束,call体的主要镊子和次要镊子,上纵束,和右半球的皮质脊髓束。TBSS分析未能检测到mTBI或OI组中初始扫描和后续扫描之间的任何DTI测量值的显着差异。在MRSI中没有发现显著差异,在初始或随访扫描时,mTBI和OI队列之间的MTR或形态计量学有或没有家庭错误(FWE)校正。我们的研究表明,在损伤的急性期,mTBI中的许多WM束受到影响,并且这些变化在90天后消失。这项研究还表明,这项研究中没有使用任何MRI模式,除了DTI,对检测mTBI急性期的变化敏感。
Multi-modal magnetic resonance imaging (MRI) that included high resolution structural imaging, diffusion tensor imaging (DTI), magnetization transfer ratio (MTR) imaging, and magnetic resonance spectroscopic imaging (MRSI) were performed in mild traumatic brain injury (mTBI) patients with negative computed tomographic scans and in an orthopedic-injured (OI) group without concomitant injury to the brain. The OI group served as a comparison group for mTBI. MRI scans were performed both in the acute phase of injury (~24 h) and at follow-up (~90 days). DTI data was analyzed using tract based spatial statistics (TBSS). Global and regional atrophies were calculated using tensor-based morphometry (TBM). MTR values were calculated using the standard method. MRSI was analyzed using LC Model. At the initial scan, the mean diffusivity (MD) was significantly higher in the mTBI cohort relative to the comparison group in several white matter (WM) regions that included internal capsule, external capsule, superior corona radiata, anterior corona radiata, posterior corona radiata, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, forceps major and forceps minor of the corpus callosum, superior longitudinal fasciculus, and corticospinal tract in the right hemisphere. TBSS analysis failed to detect significant differences in any DTI measures between the initial and follow-up scans either in the mTBI or OI group. No significant differences were found in MRSI, MTR or morphometry between the mTBI and OI cohorts either at the initial or follow-up scans with or without family wise error (FWE) correction. Our study suggests that a number of WM tracts are affected in mTBI in the acute phase of injury and that these changes disappear by 90 days. This study also suggests that none of the MRI-modalities used in this study, with the exception of DTI, is sensitive in detecting changes in the acute phase of mTBI.