■本研究旨在检查被诊断为食道癌的个体的营养状况,并比较营养不良和非营养不良患者的营养指标和肠道菌群。研究结果旨在为早期预防营养不良和开发针对肠道菌群的干预措施以治疗食管癌做出贡献。
■在2021年7月至2022年7月期间,从我院放疗科选择了80例食管癌住院患者样本,以评估NRS2002评分和PG-SGA评分。这项横断面分析旨在检查膳食营养素摄入量的差异,血液指标,身体成分,营养不良和非营养不良食管癌患者的粪便肠道菌群。此外,随机选取40例进行肠道菌群与营养不良的关系预测分析。
■食管癌患者营养风险和营养不良的发生率分别为62.5%和60%,分别。营养不良组碳水化合物和膳食纤维摄入量较低,与非营养不良组比较差异有统计学意义(P<0.05)。营养不良组的白蛋白(ALB)水平低于非营养不良组,C反应蛋白(CRP)水平较高,差异有统计学意义(P<0.05)。基础代谢率,相位角,身体细胞团,肌肉质量,骨骼肌指数,与非营养不良组相比,营养不良组的无脂体重指数均下降。细胞外水/总体内水高于非营养不良组,也有统计学意义(P<0.05)。如粪便肠道菌群的16SrDNA测序所示,营养不良组和非营养不良组之间的α和β多样性没有显着差异;在属水平上,在Selimonas中观察到显着差异,梭菌,Dielma,乳酸菌,和[Eubacterium]_siraeum_组。然而,Dielma,塞利莫纳斯,和梭菌在营养不良组明显低于非营养不良组,而缺氧球菌,Atobobium,Eubacterium_siraeum_group,和乳酸杆菌在营养不良组中明显更高。不同属与临床指标的相关性分析显示,乳酸菌与ALB呈正相关,膳食能量,细胞内水/全身水(ICW/TBW),相位角(PA),肌肉质量(MM),骨骼肌质量(SMM),身体细胞团(BCM),基础代谢率(BMR),阑尾骨骼肌质量(ASMM),全身水(TBW),无脂质量指数(FFMI),骨骼肌指数(SMI),无脂质量(FFM),重量,体重指数(BMI)(r>0,P<0.05),但与PG-SGA得分呈负相关,NRS2002评分,细胞外水/全身水(ECW/TBW)(r<0,P<0.05)。基于PG-SGA,只有一个低的准确性,以确定营养缺乏(大多数曲线下的面积(AUC)值落在0.5至0.7,甚至更低),衣原体的AUC为0.688(CI=0.518-0.858),唾液乳杆菌的AUC为0.257(CI=0.098-0.416)。基于16S数据的KEGG功能分析表明影响葡萄糖代谢途径和DNA合成或分裂的潜在差异。影响发病,发展,食管癌患者的预后。
■食管癌患者更容易营养不良。这些患者的营养状况与碳水化合物和纤维的摄入密切相关,白蛋白水平,炎症水平,和瘦体重。此外,患者的肠道菌群组成对他们的营养健康起着重要的作用。因此,调节肠道菌群有望成为解决食管癌患者营养不良的潜在治疗方法。
■ChiCTR2100048141。
UNASSIGNED: This study aims to examine the nutritional status of individuals diagnosed with esophageal cancer and compare the nutritional indicators and intestinal flora between malnourished and non-malnourished patients. The findings aim to contribute to the early prevention of malnutrition and the development of interventions targeting the intestinal flora to treat esophageal cancer.
UNASSIGNED: An 80-patient sample of hospitalized individuals with esophageal cancer was selected from the radiotherapy department of our hospital between July 2021 and July 2022 to evaluate NRS2002 scores and PG-SGA scores. This cross-sectional analysis aimed to examine the disparities in dietary nutrient intake, blood indicators, body composition, and fecal intestinal flora between malnourished and non-malnourished patients with esophageal cancer. Additionally, we randomly selected 40 cases to predict and analyze the relationship between intestinal flora and malnutrition.
UNASSIGNED: The incidence of nutritional risk and malnutrition in patients with esophageal cancer was 62.5% and 60%, respectively. The low intake of carbohydrates and dietary fiber in the malnutrition group was statistically significant compared to those in the non-malnutrition group (P < 0.05). The albumin (ALB) level was lower in the malnutrition group than in the non-malnutrition group, while the C-reactive protein (CRP) level was higher; these differences were also statistically significant (P < 0.05). The basal metabolic rate, phase angle, body cell mass, muscle mass, skeletal muscle index, and fat-free mass index in the malnutrition group all decreased compared to the non-malnutrition group. The extracellular water/total body water was higher than that in the non-malnutrition group, which was also statistically significant (P < 0.05). As shown by 16S rDNA sequencing of fecal intestinal flora, there was no significant difference in α and β diversity between the malnutrition and non-malnutrition groups; at the genus level, significant differences were observed for Selimonas, Clostridioides, Dielma, Lactobacillus, and [Eubacterium]_siraeum_group. However, Dielma, Sellimonas, and Clostridioides were significantly lower in the malnutrition group than in the non-malnutrition group, while Anaerococcus, Atopobium, Eubacterium_siraeum_group, and Lactobacillus were significantly higher in the malnutrition group. Correlation analysis between different genera and clinical indicators showed that Lactobacillus was positively correlated with ALB, dietary energy, intracellular water/total body water (ICW/TBW), phase angle (PA), muscle mass (MM), skeletal muscle mass (SMM), body cell mass (BCM), basal metabolic rate (BMR), appendicular skeletal muscle mass (ASMM), total body water (TBW), fat-free mass index (FFMI), skeletal muscle index (SMI), fat-free mass (FFM), Weight, body mass index (BMI) (r > 0, P < 0.05), but negatively correlated with PG-SGA score, NRS2002 score, and extracellular water/total body water (ECW/TBW) (r < 0, P < 0.05). Based on PG-SGA, there was only a low accuracy for identifying nutrient deficiency (most areas under curve (AUC) values fell within 0.5 to 0.7, or even lower), with Lachnoclostridium\'s AUC being 0.688 (CI = 0.518-0.858) and Lactobacillus_salivarius_g_Lactobacillus\'s AUC being 0.257 (CI = 0.098-0.416). A KEGG functional analysis based on 16S data indicated potential differences affecting glucose metabolism pathways and the synthesis or division of DNA, influencing the onset, development, and prognosis of esophageal cancer patients.
UNASSIGNED: Esophageal cancer patients are more likely to be malnourished. The nutritional status of these patients is closely linked to the intake of carbohydrates and fiber, albumin levels, inflammation levels, and lean body mass. Furthermore, the patient\'s intestinal flora composition plays a significant role in their nutritional well-being. Consequently, modulating the intestinal flora holds promise as a potential therapeutic approach for addressing malnutrition in esophageal cancer patients.
UNASSIGNED: ChiCTR2100048141.