为了突出眼睛高阶像差(HOA)和低阶像差(LOA)的大小,包括原发性先天性青光眼(PCG)患者角膜和内部平面的成分贡献。
连续治疗的PCG患者配合进行眼部检查和像差测量,为这个横断面注册了两年多,比较,单中心,揭露的研究。最佳矫正视力,折射,IOP,进行了波前像差测定和地形图(iTrace),并将结果与单侧青光眼患者未受影响的双眼以及年龄和性别匹配的对照组进行了比较,除了可治疗的屈光不正外,没有眼异常.
连续32例PCG患者的双眼(17例单侧,15个双侧)和39个对照。PCG眼LogMAR矫正视力中位数为0.68(IQR:0.2-1.8)。全眼(均方根(RMS)1.7µm与0.3µm,p=0.014),角膜(RMS1.1µmvs0.3µm,p=0.004)和内部(RMS1.1µmvs0.2µm,p=0.013)像差,以及每架飞机的HOA和LOA,PCG眼明显高于对照组。来自角膜和内部平面的成分HOA彼此呈正相关(p<0.001;rs:0.7)。与其余的相比,PCG受影响的眼睛的总像差更大。PCG中HOAs的主要亚型为昏迷和三叶形。具有角膜混浊/Haab条纹的PCG的散光明显高于角膜平面上具有透明角膜的患眼(p=0.02)。在PCG眼中,像差与角膜直径或屈光不正没有统计学关联。
显著更大的像差(总计,HOAs和LOAs,在受PCG影响的眼睛中可以看到角膜以及内部平面)。尽管这些像差对最终视觉结果的确切影响很难确定,这些可以在损害视觉功能方面发挥相关作用,从而影响这些患者的视觉康复管理。
To highlight the magnitude of ocular higher order aberrations (HOA) and lower order aberrations (LOA), including component contributions from corneal and internal planes in Primary Congenital Glaucoma (
PCG) patients.
Consecutive treated
PCG patients co-operative for ocular examination and aberrometry, were enrolled over two years for this cross-sectional, comparative, single-center, unmasked study. Best-corrected visual acuity, refraction, IOP, wavefront aberrometry and topography (iTrace) were performed and results were compared with unaffected fellow eyes of unilateral glaucoma patients as well as age and sex-matched controls with no ocular anomalies other than treatable refractive error.
Both eyes of 32 consecutive PCG patients (17 unilateral, 15 bilateral) and 39 controls were enrolled. The median LogMAR corrected distance visual acuity of
PCG eyes was 0.68 (IQR: 0.2-1.8). Total ocular (Root mean square (RMS) 1.7 µm vs 0.3 µm, p = 0.014), corneal (RMS 1.1 µm vs 0.3 µm, p = 0.004) and internal (RMS 1.1 µm vs 0.2 µm, p = 0.013) aberrations, as well as HOAs and LOAs at each plane, were significantly higher in PCG eyes than in controls. Component HOAs from corneal and internal planes were positively correlated with each other (p < 0.001; rs: 0.7). Total aberrations were greater in the affected eyes of
PCG compared to the rest. The predominant subtype of HOAs in
PCG was coma and trefoil. PCG with corneal opacity/Haab\'s striae had significantly higher astigmatism than the affected eyes with clear corneae at the corneal plane (p = 0.02). The aberrations were not statistically associated with the corneal diameter or refractive error in PCG eyes.
Significantly greater aberrations (Total, HOAs and LOAs, at corneal as well as an internal plane) were seen among eyes affected with PCG. Though the exact impact of these aberrations on the final visual outcome is difficult to determine, these could play a pertinent role in compromising visual function, thus impacting the management of visual rehabilitation in these patients.