我们观察到大麻二酚补充剂在治疗患有耐药性早期婴儿癫痫性脑病的男婴方面非常有效,消除他的顽固性强直性癫痫发作.婴儿在怀孕39周时从出生开始遭受短暂的强直性癫痫发作。脑电图显示爆发抑制和癫痫发作不能通过苯巴比妥的试验控制,唑尼沙胺,维生素B6,clobazam,左乙拉西坦,托吡酯,苯妥英,丙戊酸盐,大剂量苯巴比妥,和ACTH疗法。该男孩在130天大时出院,每天平均强直性癫痫发作20-30次。我们在第207天开始服用大麻二酚补充剂,在第219天将剂量增加到18mg/kg/d。他的癫痫发作频率降低,到第234天完全消失。这些效果得以维持,改善脑电图背景,即使在他的其他药物停药后.大麻二酚治疗耐药性癫痫的有效性已在欧洲和美国的大规模临床试验中得到证实;然而,没有这样的试验在亚洲进行。此外,迄今为止,还没有报告记录其在6个月大的婴儿中的疗效.这个重要的案例表明,大剂量的手工大麻二酚可以有效地治疗耐药癫痫患者没有获得药物级CBD。
We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy, eliminating his intractable tonic seizures. The infant began suffering clusters of brief tonic seizures from birth at 39 weeks gestation. EEG showed burst-suppression and seizures could not be controlled by trials of phenobarbital, zonisamide, vitamin B6, clobazam, levetiracetam, topiramate, phenytoin, valproate, high-dose phenobarbital, and ACTH therapy. The boy was discharged from hospital at 130 days of age still averaging tonic seizures 20-30 times per day. We started him on a cannabidiol supplement on day 207, increasing the dosage to 18 mg/kg/d on day 219. His seizures reduced in frequency and completely disappeared by day 234. These effects were maintained, with improved EEG background, even after his other medications were discontinued. Cannabidiol\'s effectiveness in treating drug-resistant epilepsy has been confirmed in large-scale clinical trials in Europe and the United States; however, no such trials have been run in Asia. In addition, no reports to date have documented its efficacy in an infant as young as six months of age. This important case suggests that high-dose artisanal cannabidiol may effectively treat drug-resistant epilepsy in patients without access to pharmaceutical-grade CBD.