■关于在现实条件下与apremilast相关的有效性和药物存活率知之甚少。
■研究患者和疾病特征对与apremilast相关的药物存活的影响,并阐明在减少银屑病面积和严重程度指数(PASI)方面的临床有效性。
■这是一个观察,回顾性,来自奥地利银屑病登记处的多中心分析。
■来自367名患者的数据符合分析条件。与apremilast相关的12个月药物存活率(即,使用该药物的患者比例)为57.3%,年龄小于40岁的患者显着降低(相对风险比=1.49,P=.007918)。性别;伴随关节炎;以前的生物治疗;肥胖;和掌足底,头皮,钉,和三齿之间的参与并没有显着影响药物的生存。12个月时,在PASI为50、75、90和100的方案中接受apremilast的患者中,应答率为80.0%,56.4%,38.2%,和22.7%,分别。
■纳入大量患者在进入研究时没有绝对PASI记录,并且在开始apremilast治疗后缺乏PASI降低的103例患者(28.1%)的随访数据。
■阿普雷米司特是一种强效的抗银屑病药物,除了年龄外,药物的生存不受大多数患者或疾病相关因素的强烈影响。40岁以下患者的药物生存期明显缩短。
UNASSIGNED: Little is known about the effectiveness and drug survival associated with apremilast under real-world conditions.
UNASSIGNED: To investigate the influence of patient and disease characteristics on drug survival associated with apremilast and to elucidate clinical effectiveness with regard to the psoriasis area and severity index (PASI) reduction.
UNASSIGNED: This was an observational, retrospective, multicenter analysis from the Austrian Psoriasis Registry.
UNASSIGNED: Data from 367 patients were eligible for analysis. The 12-month drug survival rate associated with apremilast (ie, the proportion of patients on the drug) was 57.3% and decreased significantly in patients younger than 40 years (relative hazard ratio = 1.49, P = .007918). Sex; concomitant arthritis; previous biologic therapy; obesity; and palmoplantar, scalp, nail, and intertriginous involvement did not significantly affect drug survival. At 12 months, the response rates in patients receiving apremilast per protocol with a PASI of 50, 75, 90, and 100 were 80.0%, 56.4%, 38.2%, and 22.7%, respectively.
UNASSIGNED: Inclusion of a substantial number of patients with no record of absolute PASI at study entry and lack of PASI reduction follow-up data of 103 patients (28.1%) after starting apremilast treatment.
UNASSIGNED: Apremilast is a robust antipsoriatic drug for which the drug survival is not strongly influenced by most patient- or disease-related factors except age. Drug survival is significantly shorter in patients younger than 40 years.