背景:据报道,化脓性汗腺炎(HS)和坏疽性脓皮病(PG)并存,尽管尚未系统评估HS患者中PG的患病率。
目的:评估HS患者的PG患病率。
方法:通过使用来自5500万患者的基于人群的样本的电子健康记录数据,对HS患者和非HS患者中患有PG的成年人进行横断面分析。
结果:68,232例HS患者中PG的患病率为0.18%(68,232例中的125例),与无HS患者的0.01%(31,435,166中的1835例)相比(P<.0001)。HS和克罗恩病(CD)患者的患病率(3.68%)明显高于HS但无CD的患者(0.12%)。患PG的几率为21.14(95%置信区间[CI],HS患者的17.51-25.51)是无HS患者的17.51-25.51倍。患有CD的HS患者患PG的几率是没有HS但有CD的患者的12.38倍(95%CI,9.15-16.74)。在没有CD的患者中,与没有HS的患者相比,患有HS的患者患PG的几率为26.51(95%CI,21.07-33.36)倍.
结论:我们无法在具有共存PG的人群中建立HS表型,我们也不能区分综合征和非综合征病例。
结论:HS患者的PG患病率增加,无论CD状态如何。HS患者的疼痛性溃疡需要对PG进行额外评估。
BACKGROUND: Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are reported to coexist, although the prevalence of PG among patients with HS has not been systematically evaluated.
OBJECTIVE: To evaluate PG prevalence among patients with HS.
METHODS: Cross-sectional analysis of adults with PG among patients with HS and patients without HS through use of electronic health records data from a population-based sample of 55 million patients.
RESULTS: The prevalence of PG among 68,232 patients with HS was 0.18% (125 of 68,232), compared with 0.01% (1835 of 31,435,166) among those without HS (P < .0001). Prevalence was markedly higher among patients with HS and Crohn\'s disease (CD) (3.68%) than among patients with HS but without CD (0.12%). The odds of having PG were 21.14 (95% confidence interval [CI], 17.51-25.51) times greater among patients with HS than among those without HS. Patients with HS with CD had 12.38 (95% CI, 9.15-16.74) times the odds of having PG than did patients without HS but with CD. Among patients without CD, compared with patients without HS, those with HS had 26.51 (95% CI, 21.07-33.36) times the odds of having PG.
CONCLUSIONS: We could not establish HS phenotype among those having coexistent PG, nor could we distinguish syndromic from nonsyndromic cases.
CONCLUSIONS: Patients with HS have an increased prevalence of PG, regardless of CD status. Painful ulcerations among patients with HS warrant additional evaluation for PG.