抗菌素耐药性对细菌感染的治疗构成了重大的全球威胁,特别是在非洲等低收入和中等收入地区。这项研究旨在分析2019年至2022年国家卫生实验室患者阴道拭子样本中的抗生素耐药性模式。
■这项回顾性研究检查了2019年1月1日至2022年12月31日在国家卫生实验室进行的阴道拭子分析的患者记录。伦理批准于2023年2月15日获得卫生部伦理研究批准和批准委员会。
■在622个样本中,83%进行了微生物分离和鉴定。柠檬酸杆菌属。对头孢氨苄等抗生素表现出高度耐药性(>43%),头孢他啶,萘啶酸,氨苄青霉素,庆大霉素,还有四环素.大肠杆菌对氨苄西林的耐药率超过50%,甲氧苄啶-磺胺甲恶唑,还有四环素.克雷伯菌属。和Proteusspp.对特定抗生素的耐药率超过47%。革兰阳性菌对氨苄西林的耐药率超过49%,甲氧苄啶-磺胺甲恶唑,四环素,苯唑西林,万古霉素,尤其是青霉素G,金黄色葡萄球菌对利福平或克林霉素无耐药性,而链球菌属。对利福平和万古霉素表现出100%的抗性。几个物种,包括变形杆菌,链球菌属。,金黄色葡萄球菌,和克雷伯菌属。表现出多重耐药性。
■大多数革兰氏阴性菌对氨苄青霉素的耐药性更高,为45%以上,甲氧苄啶-磺胺甲恶唑,还有四环素.在革兰氏阳性菌中,氨苄青霉素耐药率较高,甲氧苄啶-磺胺甲恶唑,四环素,苯唑西林,万古霉素,记录青霉素G。金黄色葡萄球菌对利福平和克林霉素无耐药性,和Strep.spp.表明对利福平和万古霉素100%耐药。这项研究强调了关键的差距和需要进一步探索的领域。扩大所测试的抗生素谱和研究潜在的多药耐药机制将提供对耐药模式的更全面的理解。
UNASSIGNED: Antimicrobial resistance poses a significant global threat to the treatment of bacterial infections, particularly in low- and middle-income regions such as Africa. This study is aimed at analyzing antimicrobial resistance patterns in vaginal swab samples from patients at the National Health Laboratory from 2019 to 2022.
UNASSIGNED: This retrospective study examined patient records from vaginal swab analyses performed at the National Health Laboratory between January 1, 2019, and December 31, 2022. Ethical approval was obtained from the Ministry of Health Research Ethical Approval and Clearance Committee on 15/02/2023.
UNASSIGNED: Of the 622 samples, 83% underwent microbial isolation and identification. Citrobacter spp. exhibited high resistance (>43%) to antibiotics such as cephalexin, ceftazidime, nalidixic acid, ampicillin, gentamicin, and tetracycline. E. coli showed resistance rates of more than 50% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Klebsiella spp. and Proteus spp. exhibited resistance rates that exceeded 47% to specific antibiotics. Gram-positive bacteria have resistance rates of more than 49% with ampicillin, trimethoprim-sulfamethoxazole, tetracycline,
oxacillin, vancomycin, and penicillin G. In particular, S. aureus demonstrated no resistance to rifampicin or clindamycin, while Streptococcus spp. showed 100% resistance to rifampicin and vancomycin. Several species, including Proteus species, Streptococcus spp., S. aureus, and Klebsiella spp. exhibited multidrug resistance.
UNASSIGNED: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline,
oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would provide a more comprehensive understanding of resistance patterns.