Osteochondromatosis

骨软骨瘤病
  • 文章类型: Case Reports
    评估了1岁的雄性嗜中性雪貂(Mustelaputoriusfuro)的左肘关节异常。放射学照片显示左前臂近端骨增生性病变。计算机断层扫描证实了左桡骨近端的大型薄壁扩张骨性病变,并确定了中轴脊柱的多灶性增生性病变。其中两个导致脊髓压迫。进行了左前肢截肢和全肩胛骨切除术。组织病理学显示,界限分明的肿块具有薄薄的成熟板层骨边缘和不连续的软骨帽,该软骨帽被与相邻骨连续的软骨膜/骨膜覆盖。结果与骨软骨瘤或骨软骨瘤病最一致(即,多发性软骨外生体,遗传性多发性外生体)。在该标本中未观察到恶性转化的证据。手术后三个月,与主人的口头通信确认恢复正常活动水平,没有出现神经系统症状。建议重复检查和影像学检查。
    A 1-year-old male neutered ferret (Mustela putorius furo) was evaluated for an abnormal left cubital joint. Radiographs demonstrated a proliferative osseous lesion of the left proximal antebrachium. Computed tomography confirmed a large thin-walled expansile osseous lesion of the left proximal radius and identified multifocal proliferative lesions of the axial spine, two of which caused spinal cord compression. A left forelimb amputation with total scapulectomy was performed. Histopathology revealed a well-demarcated mass with a thin rim of mature lamellar bone and a discontinuous cartilage cap covered by a perichondrial/periosteal membrane continuous with the adjacent bone. Findings were most consistent with an osteochondroma or osteochondromatosis (i.e., multiple cartilaginous exostoses, hereditary multiple exostoses). No evidence of malignant transformation was observed within this specimen. Three months post-surgery, verbal correspondence with the owner confirmed return to normal activity level and no emergence of neurological signs. Repeat examination and imaging were recommended.
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  • 文章类型: Case Reports
    滑膜软骨瘤病是一种罕见的良性疾病,由关节滑膜中存在软骨病变而定义。肌腱鞘,还有法氏囊.它最典型地影响大型关节,比如膝盖,臀部,和肩膀,但在较小的关节中也有报道。尽管如此,踝关节受累相对少见。完整的病史和临床,物理,和射线照相检查通常用于确定诊断。因此,我们报道了1例年轻的左踝原发性滑膜软骨瘤病患者,表现为左踝肿块和慢性疼痛.
    Synovial chondromatosis is a rare benign condition defined by the presence of cartilaginous lesions in the synovium of joints, tendon sheaths, and bursae. It most typically affects large joints, such as the knee, hip, and shoulder, but it is also reported in smaller joints. Nonetheless, ankle involvement is relatively uncommon. A complete history and clinical, physical, and radiographic examinations are usually used to determine the diagnosis. Hence, we reported a case of a young patient with left ankle primary synovial chondromatosis who presented with a left ankle mass and chronic pain.
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  • 文章类型: Case Reports
    滑膜软骨瘤病是一种罕见的良性疾病,涉及关节的滑膜衬里,滑膜鞘和滑囊。关节的滑膜层受到化生过程的影响,化生过程又将其转化为软骨组织。最终,它被移位并在大关节中转变成一个松散的身体。我们报告了一名24岁的年轻运动员的病例,他抱怨与右膝关节畸形增加有关的疼痛运动和关节运动受限。本病例报告旨在描述一种罕见的滑膜病理,需要关节镜滑膜切除术和诊断性关节镜来治疗,尤其是年轻人。非典型特征,在这种情况下,是从周围关节囊附着到周围软骨的化生发展,which,在作者意识到的范围内,仅记录在记录中的一个实例中。磁共振成像(MRI)显示关节积液的证据,滑膜肥大和股骨远端髁前方有一个松散的钙化体,导致髌腱前部受压,并在pop区出现高密度囊肿。治疗通常需要使用关节镜或开放方法进行部分或完全的滑膜切除术。
    Synovial chondromatosis is a rare and benign disorder that involves the synovial lining of joints, synovial sheaths and bursae. The synovial layer of the joint is affected by a metaplastic process which in turn converts it into cartilagenous tissue. Eventually, it gets dislodged and transformed into a loose body in the large joints. We report the case of a 24-year-old young athlete who presented with complaints of painful movements and restriction of joint movements associated with a growing deformity in the right knee joint. This case report aims to describe a rare synovial pathology that necessitated arthroscopic synovectomy and diagnostic arthroscopy to treat, particularly in younger individuals. The atypical feature, in this case, was metaplastic development from the peripheral joint capsule attached to the surrounding cartilage, which, to the extent that the authors are aware, has only been documented in one instance in the record. Magnetic resonance imaging (MRI) was performed which demonstrated evidence of the joint effusion, synovial hypertrophy and a loose calcific body just anterior of the distal femoral condyle causing pressure over the patellar tendon anteriorly as well as a hyper-dense cyst in the popliteal region. Treatment often requires partial or complete synovectomy with either an arthroscopic or open approach.
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  • 文章类型: Case Reports
    Synovial osteochondromatosis or synovial chondromatosis is a benign joint pathology characterized by the development of multiple cartilaginous nodules or loose bodies in the synovial membrane that typically arise in the larger joints of the body. It usually presents as joint pain and, as seen in the present case, can occasionally be missed. Diagnosis involves a combination of clinical evaluation, imaging studies, and histopathological evaluation (which is confirmatory). Treatment depends on the severity of the disease, symptoms, and the patient\'s social situation, and may include monitoring for asymptomatic cases, non-surgical management (pain medications and physical therapy), or surgical intervention. Surgical intervention may include arthroscopic removal of loose bodies, synovectomy, or reconstruction/replacement in severe situations. Prognosis has a direct relationship to how early the disease is diagnosed. Early intervention with appropriate management can help alleviate symptoms; however, if left unmanaged, it can lead to joint damage and osteoarthritis or very rarely, malignant transformation into chondrosarcoma. This report describes the case of a 62-year-old female with complaints of bilateral knee pain who was originally diagnosed with osteoarthritis based on clinical exam and X-rays. Two magnetic resonance imaging (MRI) scans were done three years apart, with synovial osteochondromatosis being on the differential after the second scan. A left knee major synovectomy was conducted after the second MRI reading, where rubbery masses of tissue along with loose fragments were removed. Fluid from the tissue masses was sent to culture and pathology for interpretation. Two weeks post the surgery, the patient\'s pain improved tremendously, with adequate ambulation independently. Histopathology came back positive for synovial osteochondromatosis. This case report highlights the importance of keeping this joint pathology on the differential when treating patients with joint pain and interpreting imaging.
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  • 文章类型: Journal Article
    猫骨软骨瘤病是与猫白血病病毒(FeLV)感染相关的自发性骨软骨外生症,或由于外生体糖基转移酶1(EXT1)基因的移码变异。骨软骨瘤病被诊断为仅在室内,12岁,绝育的女性,俄罗斯蓝猫射线照片显示肘部双侧钙化增生,肋软骨和胸软骨关节,扭曲了正常的骨骼结构.严重的,增殖的关节表现一致,圆形肿块,导致完全强直.主要的组织病理学发现是骨软骨增生,由多个不规则的分化良好的透明软骨岛组成,并由类骨组织包围和界定。骨软骨瘤的免疫组织化学,骨髓和纵隔淋巴结,使用主要的抗FeLVgp70抗体,骨髓前病毒DNA实时聚合酶链反应阴性。对EXT1基因的外显子6进行测序,并且核苷酸BLAST分析证明不存在移码变体。这项研究报告了10岁以上动物中唯一的自发性猫科动物骨软骨瘤病病例。
    Feline osteochondromatosis is a spontaneous osteocartilaginous exostosis associated with feline leukaemia virus (FeLV) infection or due to a frameshift variant in the exostosin glycosyltransferase 1 (EXT1) gene. Osteochondromatosis was diagnosed in an indoor-only, 12-year-old, neutered female, Russian Blue cat. Radiographs revealed bilateral calcified proliferations in the elbow, costochondral and sternochondral joints, which distorted the normal skeletal structure. Grossly, the proliferated joints presented with consistent, rounded masses, causing complete ankylosis. The main histopathological finding was an osteocartilaginous proliferation composed of multiple irregular islands of well-differentiated hyaline cartilage surrounded and delimited by osteoid tissue. Immunohistochemistry of the osteochondromas, bone marrow and mediastinal lymph nodes, using a primary anti-FeLV gp70 antibody, and FeLV proviral DNA real-time polymerase chain reaction on bone marrow were negative. Sequencing of exon 6 of the EXT1 gene was performed and nucleotide BLAST analysis demonstrated the absence of a frameshift variant. This study reports the only case of spontaneous feline osteochondromatosis in an animal more than 10 years old.
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  • 文章类型: Journal Article
    除了一些病例报告,尚未研究骨软骨瘤病的骶髂关节(SIJ)受累。我们旨在使用横断面成像来确定这种参与的患病率和特征。
    在这项回顾性研究中,3名观察员(1名初级放射科医师和2名肌肉骨骼放射科医师)独立回顾了我们数据库中患有骨软骨瘤(≥2例跨骨骼骨软骨瘤)的患者的计算机断层扫描(CT)或磁共振成像(MRI)的SIJ受累.最终决定是由两位肌肉骨骼放射科医生在后来的联席会议上达成的共识。
    在我们数据库中的36例骨软骨瘤病患者中,22例(61%)有覆盖SIJ的横断面成像(14例女性,男性8例;年龄范围7-66岁;平均年龄23岁;MRI13例,9CT)。其中,16例(73%)患有关节内骨软骨瘤。为了在横断面成像中识别SIJ骨软骨瘤,肌肉骨骼放射科医师和初级放射科医师与两位肌肉骨骼放射科医师的最终共识决定之间的观察者间达成了实质性共识[κ=0.67;95%置信区间(CI):0.34,1.00]。在横断面成像的队列中,在6例有(n=2)和无(n=4)骶髂骨软骨瘤的不同患者中发现了附件SIJ(n=6,27%)和髂骶复合体(n=2,9%)的解剖变异.
    横断面影像显示SIJ频繁(73%)受累于骨软骨瘤病,which,虽然是一种罕见的疾病,然而,在鉴别诊断此类SIJ解剖变异体如副SIJ和髂骶骨复合体时,需要加以考虑.在骨软骨瘤病患者中,将这些变体与骨软骨瘤区分开具有挑战性。
    Apart from a few case reports, sacroiliac joint (SIJ) involvement in osteochondromatosis has not been studied. We aimed to determine the prevalence and characteristics of such involvement using cross-sectional imaging.
    In this retrospective study, three observers (one junior radiologist and two musculoskeletal radiologists) independently reviewed computed tomography (CT) or magnetic resonance imaging (MRI) of patients in our database who had osteochondromatosis (≥2 osteochondromas across the skeleton) for SIJ involvement. The final decision was reached by the consensus of the two musculoskeletal radiologists in a later joint session.
    Of the 36 patients with osteochondromatosis in our database, 22 (61%) had cross-sectional imaging covering SIJs (14 females, 8 males; age range 7-66 years; mean age 23 years; 13 MRI, 9 CT). Of these, 16 (73%) had intra-articular osteochondromas. For identifying SIJ osteochondromas on cross-sectional imaging, interobserver agreement was substantial [κ = 0.67; 95% confidence interval (CI): 0.34, 1.00] between the musculoskeletal radiologists and moderate (κ = 0.59; 95% CI: 0.23, 0.94) between the junior radiologist and the final consensus decision of the two musculoskeletal radiologists. In the cohort with cross-sectional imaging, the anatomical variations of the accessory SIJ (n = 6, 27%) and iliosacral complex (n = 2, 9%) were identified in six different patients with (n = 2) and without (n = 4) sacroiliac osteochondromas.
    Cross-sectional imaging shows frequent (73%) SIJ involvement in osteochondromatosis, which, although a rare disorder, nevertheless needs to be considered in the differential diagnosis of such SIJ anatomical variants as the accessory SIJ and iliosacral complex. Differentiating these variants from osteochondromas is challenging in patients with osteochondromatosis.
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  • 文章类型: Journal Article
    UNASSIGNED:肩关节滑膜骨软骨瘤病(SOC)是一种罕见的疾病,特征不明确。这项研究评估了与其他关节SOC不同的肩关节SOC的临床特征和术后功能结果。
    UNASSIGNED:回顾性评估了接受关节镜检查的28个肩关节SOC的特征。十个肩膀(35.7%)患有肩袖撕裂(RCT),并同时接受关节镜肩袖修复。平均随访期为83.6个月(范围,24-154个月)。比较了有和没有伴随RCT的病例之间的人口学特征和关节镜下局部的松散体。射线照相术,超声检查,或术前和术后进行磁共振成像。对所有病例进行疼痛视觉模拟量表(VAS)评分和满意度评定,评估肩关节功能评分,同时进行RCT检查.
    UNASSIGNED:无随机对照试验的患者平均年龄为36.2±15.6岁,有随机对照试验的患者平均年龄为58.3±7.2岁。七个肩膀(7%)患有骨关节炎。关节镜检查显示多个空间中有松散的身体,包括肱骨关节,肩峰下(SA)空间,和肱二头肌肌腱鞘。总的来说,在12个肩部的多个空间发现了松散的尸体(42.9%)。在SA空间中仅在没有RCT的4个肩部(22.2%)和有RCT的7个肩部(70.0%)中发现了松散的身体。疼痛的VAS从3.9±2.3显著降低至1.1±1.3(p<0.001)。关节镜治疗后并发RCT患者的功能评分显着增加(均p<0.05)。术后成像的22名患者中有3名(13.6%)出现SOC复发,但没有患者有复发性RCT。
    UNASSIGNED:通过关节镜治疗可实现疼痛缓解和患者满意度。与其他关节不同,松散的身体可以同时出现在肩部的几个空间,包括肱骨关节,SA空间,和肱二头肌肌腱鞘。早期诊断SA空间的SOC有助于预防骨关节炎和RCT进展。
    UNASSIGNED: Synovial osteochondromatosis (SOC) of the shoulder is a rare condition with unclear characteristics. This study evaluated the clinical features and postoperative functional outcomes of SOC of the shoulder that are distinct from SOC of other joints.
    UNASSIGNED: The characteristics of 28 shoulders with SOC that underwent arthroscopy were retrospectively assessed. Ten shoulders (35.7%) had rotator cuff tears (RCTs) and underwent concomitant arthroscopic rotator cuff repair. The mean follow-up period was 83.6 months (range, 24-154 months). Demographic characteristics and loose bodies localized under arthroscopy were compared between cases with and without concomitant RCTs. Radiography, ultrasonography, or magnetic resonance imaging were performed preoperatively and postoperatively. Visual analog scale (VAS) scores for pain and satisfaction were evaluated for all cases, and functional scores were assessed in shoulders with concomitant RCTs.
    UNASSIGNED: The average age was 36.2 ± 15.6 years among patients without RCTs and 58.3 ± 7.2 years among patients with RCTs. Seven shoulders (7%) had osteoarthritis. Arthroscopy revealed loose bodies in multiple spaces, including the glenohumeral joint, subacromial (SA) space, and biceps tendon sheath. Overall, loose bodies were found in multiple spaces in 12 shoulders (42.9%). Loose bodies were found in the SA space only in 4 shoulders (22.2%) without RCTs and in 7 shoulders (70.0%) with RCTs. VAS for pain decreased significantly from 3.9 ± 2.3 to 1.1 ± 1.3 (p < 0.001). The functional scores increased significantly after arthroscopic management for patients with concurrent RCTs (all p < 0.05). Recurrence of SOC occurred in 3 of the 22 shoulders (13.6%) who underwent postoperative imaging, but no patient had a recurrent RCT.
    UNASSIGNED: Pain relief and patient satisfaction were achieved via arthroscopic management. Unlike in other joints, loose bodies can occur simultaneously in several spaces in the shoulder, including the glenohumeral joint, SA space, and biceps tendon sheath. Early diagnosis of SOC of the SA space can help prevent osteoarthritis and RCT progression.
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  • 文章类型: Case Reports
    踝关节原发性滑膜骨软骨瘤病是年轻人的一种罕见且良性的疾病。它的特征是滑膜下透明软骨的多个结节的形成。它通常是无症状的,但有时可以通过疼痛或关节活动障碍来揭示。X线和CT扫描可以很容易地诊断钙化骨软骨瘤,但是超声和MRI可以通过可视化非钙化异物来提供更快的诊断。关节镜下手术仍然是最好的治疗选择,然而,这种病理仍导致不到1/3的病例复发。
    Primary synovial osteochondromatosis of the ankle is a rare and benign disease of the young adult. It is characterized by the formation of multiple nodules of hyaline cartilage under the synovium. It is usually asymptomatic but can sometimes be revealed by pain or joint mobility disorders. X-rays and CT scans can easily diagnose calcified osteochondromas, but ultrasound and MRI can provide a quicker diagnosis by visualizing non-calcified foreign bodies. Surgery under arthroscopy remains the best therapeutic choice, however, this pathology still causes recurrence in less than 1/3 of cases.
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  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    未经证实:滑膜软骨瘤病是指关节内的细胞形成良性软骨肿瘤。这种良性软骨化生导致在关节内形成多个关节内松散体。
    未经调查:这是一个59岁的女性,严重的左髋部疼痛位于腹股沟,2年前开始。髋关节屈曲严重受限,扩展,内旋疼痛,和半英寸的左腿缩短。射线照片显示左股骨颈周围有多个圆形混浊。MRI显示大量,小圆形关节内松散体,在左髋关节内约5-6毫米。
    UNASSIGNED:使用髋部外侧入路在大转子部分进行截骨。识别髋囊,然后通过囊形成S形切口。重复的髋关节脱位可以改善可视化,从而更容易地进一步去除困难的碎片。关闭胶囊并重新连接截骨术。与术前相比,发现运动范围显着改善。无需进一步固定,患者的皮下组织以正常方式闭合。
    UNASSIGNED:我们案例中使用的技术涉及采用股骨转子翻转截骨术的外侧入路,以保留股骨内侧旋支动脉和外部转子。这类似于Ganz在2001年使用后入路描述的方法。按照这种方法,然后,髋关节脱位并向前暴露,关节完全可视化,股骨头和髋臼之间的间隙约为11厘米。手术脱位可以去除股骨头和颈部交界处周围困难的软骨瘤和骨赘。多项研究支持手术脱位作为SC的特殊治疗方法的想法。
    UNASSIGNED: Synovial chondromatosis is a condition where the cells lining a joint form benign cartilaginous tumors. This benign cartilage metaplasia results in the formation of multiple intra-articular loose bodies within a joint.
    UNASSIGNED: This case is a 59-year-old female that presented with constant, severe left hip pain that was localized to the groin and began 2 years ago. There were severe limitation of hip flexion, extension, pain on internal rotation, and a half inch left leg shortening. Radiographs demonstrated multiple round opacities surrounding the left femoral neck. MRI showed numerous, small rounded intra-articular loose bodies, measuring about 5-6 mm each within the left hip joint.
    UNASSIGNED: A lateral approach toward the hip was used to perform an osteotomy at the portion of the greater trochanter. The hip capsule was identified and an S-shaped incision was then made through the capsule. Repetitive hip dislocations allowed for improved visualization making further removal of the difficult fragments much easier. The capsule was closed and the osteotomy was reattached. Range of motion was found to be significantly improved compared to preoperatively. No further fixation was necessary and the patient\'s subcutaneous tissue was closed in normal fashion.
    UNASSIGNED: The technique used in our case involves a lateral approach with a trochanteric flip osteotomy to preserve the medial femoral circumflex artery and external rotators. This is similar to the approach described by Ganz in 2001 who used a posterior approach. Following the approach, the hip is then dislocated and exposed anteriorly with full visualization of the joint with a gap of about 11 cm between the femoral head and acetabulum. Surgical dislocation allows for the removal of difficult chondromas and osteophytes around the femoral head-and-neck junction. Multiple studies support the idea of surgical dislocation as an exceptional treatment method for SC.
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