目的:18F-N-(2-(二乙基氨基)乙基)-5-(2-(2-(2-氟乙氧基)乙氧基)吡啶酰胺(18F-PFPN)是一种新型的正电子发射断层扫描(PET)探针,旨在特异性靶向黑色素。本研究旨在评估18F-PFPN在眼部或眼眶黑色素瘤患者中的诊断可行性。
方法:3例经病理证实的眼或眼眶黑色素瘤患者(1例男性,两名女性;年龄41-59岁)进行了回顾性审查。每位患者均接受了全面的18F-PFPN和18F-氟代脱氧葡萄糖(18F-FDG)PET扫描。比较了18F-PFPN和18F-FDGPET显像中病灶的最大标准化摄取值(SUVmax)和背景组织引起的干扰。此外,检查了葡萄膜和视网膜中固有色素对结果解释的影响。每位患者的对侧非肿瘤眼作为对照。
结果:使用18F-PFPNPET检测到所有原发性肿瘤(3/3),而使用18F-FDGPET仅检测到两个原发性肿瘤。在每个病变内,18F-PFPN的SUVmax是18F-FDG的2.6至8.3倍。关于PET成像的质量,18F-FDGPET在脑和眼周组织中的生理摄取限制了肿瘤的成像。然而,18F-PFPNPET使这种干扰最小化。值得注意的是,葡萄膜和视网膜中的固有色素没有引起18F-PFPN的异常浓度,因为在健康的对侧眼中未检测到18F-PFPN的异常摄取。
结论:与18F-FDG相比,18F-PFPN对眼部和眼眶黑色素瘤的检出率更高,周围组织的干扰最小。这表明18F-PFPN可能是一种有前途的临床诊断工具,可用于区分恶性黑色素瘤和眼眶黑色素瘤中的良性色素沉着。
OBJECTIVE: 18F-N-(2-(Diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy) picolinamide (18F-PFPN) is a novel positron emission tomography (PET) probe designed to specifically targets melanin. This study aimed to evaluate the diagnostic feasibility of 18F-PFPN in patients with ocular or orbital melanoma.
METHODS: Three patients with pathologically confirmed ocular or orbital melanoma (one male, two females; age 41-59 years) were retrospectively reviewed. Each patient underwent comprehensive 18F-PFPN and 18F-fluorodeoxyglucose (18F-FDG) PET scans. The maximum standardized uptake value (SUVmax) of the lesion and the interference caused by background tissue were compared between 18F-PFPN and 18F-FDG PET imaging. In addition, the effect of intrinsic pigments in the uvea and retina on the interpretation of the results was examined. The contralateral non-tumorous eye of each patient served as a control.
RESULTS: All primary tumors (3/3) were detected using 18F-PFPN PET, while only two primary tumors were detected using 18F-FDG PET. Within each lesion, the SUVmax of 18F-PFPN was 2.6 to 8.3 times higher than that of 18F-FDG. Regarding the quality of PET imaging, the physiological uptake of 18F-FDG PET in the brain and periocular tissues limited the imaging of tumors. However, 18F-PFPN PET minimized this interference. Notably, intrinsic pigments in the uvea and retina did not cause abnormal concentrations of 18F-PFPN, as no anomalous uptake of 18F-PFPN was detected in the healthy contralateral eyes.
CONCLUSIONS: Compared to 18F-FDG, 18F-PFPN demonstrated higher detection rates for ocular and orbital melanomas with minimal interference from surrounding tissues. This suggests that 18F-PFPN could be a promising clinical diagnostic tool for distinguishing malignant melanoma from benign pigmentation in ocular and orbital melanomas.