未经证实:尽管新出现的证据表明牙周炎可能会增加患癌症的风险,合并症和生活方式行为,如吸烟和体重指数(BMI),可能混淆了这个报道的协会。这项研究旨在调查慢性牙周炎是否与癌症风险相关,全国数据库。
未经评估:我们进行了以人口为基础的,采用2003年1月至2015年12月韩国国家健康保险队列数据库数据进行回顾性队列研究.我们纳入了713,201名没有癌症史的个体,随访长达10年。混杂因素包括人口因素(年龄,性别,收入,和住宅区),生活方式行为(吸烟史和BMI),和合并症,比如高血压,糖尿病,心力衰竭,和肺部疾病,使用Charlson合并症指数。多变量Cox回归分析用于估计癌症风险的校正风险比(aHR)。
未经批准:在713,201名参与者中,53,075人患有牙周炎,并置于牙周炎组;其余660,126人作为对照组。总的来说,牙周炎组癌症的累积发病率是对照组的2.2倍。调整年龄后,牙周炎组患癌症的风险比对照组增加,性别,合并症,BMI,和吸烟史(AHR,1.129;95%置信区间[CI],1.089-1.171;P<0.0001)。当检查特定的癌症类型时,还观察到牙周炎和胃癌之间存在显著关联(AHR,1.136;95%CI,1.042-1.239;P=0.0037),结肠癌(aHR,1.129;95%CI,1.029-1.239;P=0.0105),肺癌(aHR,1.127;95%CI,1.008-1.260;P=0.0353),膀胱癌(AHR,1.307;95%CI,1.071-1.595;P=0.0085),甲状腺癌(aHR,1.191;95%CI,1.085-1.308;P=0.0002),和白血病(AHR,1.394;95%CI,1.039-1.872;P=0.0270)。在被诊断为原发性恶性肿瘤后存活5年的癌症幸存者中,继发性恶性肿瘤的发展与牙周炎之间没有显着关联。
未经批准:牙周病,包括牙周炎,与癌症风险增加有关,在控制了混杂因素后仍然存在。需要进一步的前瞻性研究来建立因果关系。
UNASSIGNED: Although emerging evidence suggests that periodontitis might increase the risk of cancer, comorbidity and lifestyle behaviors, such as smoking and body mass index (BMI), may have confounded this reported association. This study aimed to investigate whether chronic periodontitis is associated with cancer risk using a large, nationwide database.
UNASSIGNED: We conducted a population-based, retrospective cohort study using data from the Korean National Health Insurance Cohort Database obtained between January 2003 and December 2015. We included 713,201 individuals without a history of cancer who were followed up to 10 years. Confounding factors included demographic factors (age, sex, income, and residential area), lifestyle behaviors (smoking history and BMI), and comorbidities, such as hypertension, diabetes, heart failure, and pulmonary disease, using the Charlson Comorbidity Index. Multivariable Cox regression analysis was applied to estimate the adjusted hazard ratio (aHR) for cancer risk.
UNASSIGNED: Of the 713,201 participants, 53,075 had periodontitis and were placed in the periodontitis group; the remaining 660,126 individuals were included as the control group. Overall, the cumulative incidence of cancer in the periodontitis group was 2.2 times higher than that in the control group. The periodontitis group had an increased risk of total cancer compared to the control group after adjusting for age, sex, comorbidities, BMI, and smoking history (aHR, 1.129; 95% confidence interval [CI], 1.089-1.171; P<0.0001). When examining specific cancer types, significant associations were also observed between periodontitis and stomach cancer (aHR, 1.136; 95% CI, 1.042-1.239; P=0.0037), colon cancer (aHR, 1.129; 95% CI, 1.029-1.239; P=0.0105), lung cancer (aHR, 1.127; 95% CI, 1.008-1.260; P=0.0353), bladder cancer (aHR, 1.307; 95% CI, 1.071-1.595; P=0.0085), thyroid cancer (aHR, 1.191; 95% CI, 1.085-1.308; P=0.0002), and leukemia (aHR, 1.394; 95% CI, 1.039-1.872; P=0.0270). There was no significant association between the development of secondary malignancy and periodontitis in cancer survivors who were alive 5 years after they were diagnosed with the primary malignancy.
UNASSIGNED: Periodontal disease, including periodontitis, was associated with increased risk of cancer, which persisted after controlling for confounding factors. Further prospective research is warranted to establish a causal relationship.