■海鲜过敏(SA),包括对贝类(甲壳类和软体动物)和鱼类过敏,是引起过敏反应的四种最常见的食物过敏之一,但不同国家的SA临床管理数据有限.
■我们试图描述大量鱼类和贝类过敏患者的特征,并促进对这种日益常见的过敏性疾病的未来护理标准化。
■我们进行了回顾性研究,观察,2015年至2019年在美国和英国7家医院进行的945例患者的非干预性研究,以评估SA。卡方检验用于检测家族史的差异,病史,以及2个国家/地区患者之间的当前症状。
■在这两个国家中,SA患者的过敏反应诊断不足与肾上腺素(肾上腺素)自动注射器使用不足有关。仅在皮肤或血清学测试结果为阴性时才使用口服食物激发。哮喘和过敏性鼻炎在美国SA患者中更为常见,但湿疹在英国SA患者中更为常见(P<.001)。呼吸,胃肠,英国SA患者的神经系统症状高于美国SA患者(P<0.001)。
■在鱼类和贝类过敏患者的国际多中心队列中,管理上有改进的机会。过敏性反应的医生鉴定,使用诊断性口服食物挑战,在英国和美国,使用肾上腺素的过敏反应治疗存在显著的知识差距,需要改进.统一发展有契机,SA的标准化诊断方案,为过敏专科医生和受训者分发。
UNASSIGNED: Seafood allergy (SA), including allergy to shellfish (crustacean and mollusks) and fish, is among the 4 most common food allergies causing anaphylaxis, but there are limited data showing SA clinical management in different countries.
UNASSIGNED: We sought to characterize a large cohort of patients with fish and shellfish allergy and to facilitate standardization of future care for this increasingly common allergic disease.
UNASSIGNED: We performed a retrospective, observational, noninterventional study from 945 patients from 2015 to 2019 in 7 hospitals in the United States and the United Kingdom to evaluate SA. A chi-square test was used to detect differences in family history, medical history, and current symptoms between patients in 2 countries.
UNASSIGNED: Underdiagnosed anaphylaxis in patients with SA was associated with underuse of epinephrine (adrenaline) autoinjectors in both countries. Oral food challenge was used only when skin or serologic test results were negative. Asthma and allergic rhinitis were more common in the US patients with SA, but eczema was more common in UK patients with SA (P < .001). Respiratory, gastrointestinal, and neurological symptoms were higher in UK patients with SA than in US patients with SA (P < .001).
UNASSIGNED: In international multicenter cohorts of patients with fish and shellfish allergy, there are opportunities for improvement in management. Physician identification of anaphylaxis, use of diagnostic oral food challenges, and anaphylaxis treatment with epinephrine are areas with significant knowledge gaps in need of improvement in the United Kingdom and the United States. There is an opportunity for the development of unified, standardized diagnostic protocols for SA with distribution for allergists and trainees.