目的:切除口腔肿瘤通常会引起短期或长期的后遗症,如咀嚼,言语和吞咽障碍。为了保持这种功能,有必要保持口腔的衬里,舌头的灵活性和敏感性。肿瘤切除导致的口腔粘膜缺损的重建选择包括初次闭合,粘膜和皮肤移植物,蒂和微血管游离皮瓣,和真皮基质。
方法:对接受口腔内缺损重建的患者进行回顾性研究,切除T1,T2恶性肿瘤后,通过双层真皮基质的放置。
方法:自2021年至2022年,对47例鳞状细胞癌切除后口腔黏膜缺损患者进行治疗。所有患者均受到T1-T2鳞状细胞癌的影响。对于每个病人来说,收集了有关疾病部位的数据,最初的阶段,手术缺损的大小,术后几个月的并发症和结果。
结果:在所有治疗病例中,手术缺损累及脸颊粘膜,平均大小为5.45cm的口腔地板或舌头。接受这种类型重建的患者在手术后6个月受益于口腔内伤口的良好愈合和口腔功能的良好恢复。在患者总数中,仅有2例报告了膜附着失败。
结论:根据我们研究报告的数据,真皮基质是用于小/中型口内粘膜缺损的肿瘤重建手术的有效替代方案,因为它允许伤口的上皮再形成.
OBJECTIVE: Resection of tumors of oral cavity usually causes short- or long-term sequelae such as chewing, speech and swallowing impairment. To preserve this function it is necessary to maintain the lining of the oral cavity, the mobility and sensitivity of the tongue. Reconstructive options for oral mucosal defects resulting from tumor resection included primary closure, mucosal and skin grafts, pedicle and microvascular free flaps, and dermal matrix.
METHODS: Retrospective study on patients undergoing reconstruction of intraoral defects, after removal of T1, T2 malignant tumors, by placement of bilayer dermal matrix.
METHODS: From 2021 to 2022, 47 patients with oral mucosa defects after removal of squamous cell carcinoma were treated. All patients were affected by a T1-T2 squamous cell carcinoma. For each patient, data were collected regarding the site of the disease, the initial staging, the size of the surgical defect, the complications and the outcome months after the operation.
RESULTS: In all treated cases the surgical defect involved the mucosa of the cheek, the oral floor or the tongue with an average size of 5.45cm2. Patients who underwent this type of reconstruction benefited from excellent healing of intraoral wounds and good restoration of oral function 6 months after surgery. Out of the total number of patients, membrane attachment failure was reported in only two cases.
CONCLUSIONS: As emerges from the data reported in our study, the dermal matrix represents a valid alternative in oncological reconstructive surgery for small/medium-sized intraoral mucosal defects because it allows re-epithelialization of the wound.