缺乏更有效的乳腺癌治疗方法增加了乳腺癌患者的死亡率。最近的努力已经建立了有效的治疗方法来减少乳腺癌相关的死亡。使用生物相容性基于多糖的纳米结构作为递送系统的吸引力不断增加,已引起人们对各种疾病治疗的兴趣。尤其是乳腺癌治疗。广泛的治疗货物,包括生物活性或化学药物,寡核苷酸、肽,和靶向生物标志物被认为是理解它们对乳腺癌的抗癌作用。裸试剂或不期望的构建体的一些限制,例如没有或低生物利用度,酶消化,短程稳定性,低细胞摄取,溶解性差,和低表面积,降低了他们的效力。然而,治疗成分的纳米级制剂为解决上述问题提供了有希望的平台。例如,一些有能力的多糖,包括纤维素,果胶,壳聚糖,海藻酸盐,还有葡聚糖,被开发为具有出色纳米结构的乳腺癌治疗剂。这篇综述仔细研究了用于形成纳米颗粒(NP)的有益多糖的特征。它还强调了反义寡核苷酸(ASO)的应用,和由多糖制成的NP用于治疗乳腺癌,并提出了增强这些颗粒的方法,用于未来的研究。
The lack of more effective therapies for breast cancer has enhanced mortality among breast cancer patients. Recent efforts have established efficient treatments to reduce breast cancer-related deaths. The ever-increasing attraction to employing biocompatible polysaccharide-based nanostructures as delivery systems has created interest in various disease therapies, especially breast cancer treatment. A wide range of therapeutic cargo comprising bioactive or chemical drugs, oligonucleotides, peptides, and targeted biomarkers have been considered to comprehend their anti-cancer effects against breast cancer. Some limitations of naked agents or undesired constructs, such as no or low bioavailability, enzymatic digestion, short-range stability, low-cellular uptake, poor solubility, and low surface area, have lessened their effectiveness. However, nanoscale formulations of therapeutic ingredients have provided a promising platform to address the mentioned concerns. For instance, some capable polysaccharides, including cellulose, pectin, chitosan, alginate, and dextran, were developed as breast cancer therapeutics with great nanoparticle structures. This review carefully examines the characteristics of beneficial polysaccharides that are utilized in the formation of nanoparticles (NPs). It also highlights the applications of antisense oligonucleotides (ASOs), and NPs made from polysaccharides in the treatment of breast cancer and suggests ways to enhance these particles for future research.