背景:骨关节炎(OA)与高血压之间的关联是观察性研究中持续争论的主题,它们之间潜在的因果关系仍然难以捉摸。
方法:本研究回顾性纳入了2013年至2020年国家健康和营养调查(NHANES)的24,871名参与者。采用加权logistic回归分析OA与高血压的关系。此外,进行了孟德尔随机化(MR)分析,以探讨OA和高血压之间的潜在因果关系。
结果:在NHANES数据中,在调整了多个混杂因素后,OA与高血压的关系无统计学意义(OR1.30,95%CI,0.97~1.73,P=0.089)。然而,在男性中,OA似乎与较高的高血压风险相关(OR2.25,95%CI,1.17-4.32,P=0.019)。此外,MR结果表明多种OA表型与高血压之间没有关系:膝关节OA(IVW,OR1.024,95%CI:0.931-1.126,P=0.626),髋关节OA(IVW,OR0.990,95%CI:0.941-1.042,P=0.704),膝盖或臀部OA(IVW,OR1.005,95%CI:0.915-1.105,P=0.911),和来自英国生物库的OA(IVW,OR0.796,95%CI:0.233-2.714,P=0.715)。重要的是,这些发现在不同性别之间和反向MR中保持一致.
结论:我们的研究发现,在观察性研究中,OA患者仅在男性中具有较高的高血压风险。然而,MR分析未发现OA与高血压之间的任何因果关系。
BACKGROUND: The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive.
METHODS: This study retrospectively included 24,871 participants in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Weighted logistic regression was performed to investigate the connection between OA and hypertension. Additionally, Mendelian randomization (MR) analysis was conducted to explore the potential causal relationship between OA and hypertension.
RESULTS: In the NHANES data, after adjusting for multiple confounding factors, there was no significant relationship between OA and hypertension (OR 1.30, 95% CI, 0.97-1.73, P = 0.089). However, among males, OA appeared to be associated with a higher risk of hypertension (OR 2.25, 95% CI, 1.17-4.32, P = 0.019). Furthermore, MR results indicate no relationship between multiple OA phenotypes and hypertension: knee OA (IVW, OR 1.024, 95% CI: 0.931-1.126, P = 0.626), hip OA (IVW, OR 0.990, 95% CI: 0.941-1.042, P = 0.704), knee or hip OA (IVW, OR 1.005, 95% CI: 0.915-1.105, P = 0.911), and OA from UK Biobank (IVW, OR 0.796, 95% CI: 0.233-2.714, P = 0.715). Importantly, these findings remained consistent across different genders and in reverse MR.
CONCLUSIONS: Our study found that OA patients had a higher risk of hypertension only among males in the observational study. However, MR analysis did not uncover any causal relationship between OA and hypertension.