背景:2017年,西班牙皮肤病和性病学会银屑病工作组(PWG)设计了最小疾病活动(MDA)标准,以确定疾病活动水平。我们在此介绍观测结果,横截面,这些标准在全国范围内应用的多中心研究。
方法:我们进行了非随机抽样,分层以实现无活动性关节炎的寻常型银屑病(Ps)连续患者的自主神经和省级代表。总共包括830名患者:493名男性(59.5%),平均年龄51.4岁(SD,14.2),来自西班牙所有自治区(休达和梅利利亚除外)和50个省中的44个(88%)。获得了一份带有人口统计数据的问卷,DLQI,主观评估——从0到10——瘙痒,红斑,脱皮,可见性,以及患者的PASI和BSA.
结果:超过50%不符合MDA标准(491;59.2%),各地区报告的显著差异,性别,和年龄。此外,根据所使用的治疗方法报告了显著差异(p<0.001).与其他疗法相比,使用生物疗法与更高的MDA依从性相关(59.4%vs23.3%)。在各种生物疗法之间没有报告差异。
结论:MDA的总体依从性较低,差异取决于地理位置,性别,年龄,和使用的药物,然而,这些因素都没有单独证明它们是合理的。
BACKGROUND: In 2017, the Spanish Academy of Dermatology and Venereology Psoriasis Working Group (PWG) designed the Minimal Disease Activity (MDA) criteria to determine the level of disease activity. We hereby present the results of an observational, cross-sectional, multicenter study of the nationwide application of these criteria.
METHODS: We conducted a non-randomized sampling, stratified to achieve autonomic and provincial representation of consecutive patients with psoriasis (Ps) vulgaris without active arthritis. A total of 830 patients were included: 493 men (59.5%), with a mean age of 51.4 years (SD, 14.2), from all autonomous regions of Spain (except for Ceuta and Melilla) and 44 (88%) out of the 50 provinces. A questionnaire was obtained with demographic data, DLQI, subjective assessment-on a scale from 0 to 10-of itching, erythema, desquamation, visibility, and the patients\' PASI and BSA.
RESULTS: More than 50% failed to meet the MDA criteria (491; 59.2%), with significant differences being reported by region, sex, and age. Additionally, significant differences were reported based on the therapy used (P<.001). The use of biological therapies was associated with higher MDA compliance compared to other therapies (59.4% vs 23.3%). No differences were reported among various biological therapies.
CONCLUSIONS: The overall rate of MDA compliance is low, with differences being based on geographic location, sex, age, and drug used, yet none of these factors separately justify them.