BACKGROUND: Acute intestinal obstruction (AIO) is a syndrome defined by the cessation of intestinal transit caused by an obstacle or paralysis of intestinal peristalsis. It is a diagnostic and therapeutic emergency. The multi-bar CT scan has revolutionized the management of this pathology, as it allows the surgeon to answer different questions. The aim of our study was to describe the CT aspects of AIO, to determine the etiologies and to show the place of CT in the management of AIO.
METHODS: This was a retrospective descriptive study conducted over 5 years (January 2010 to December 2015) on 81 patient files collected in the imaging departments of the CHU Aristide Le Dantec and the Hôpital Principal. The files retained were those whose diagnosis was established from the clinic, imaging and/or not from surgery.
RESULTS: Mechanical occlusions represented 94.4% (76 cases) and functional occlusions 5.6% (05 cases). They were of the small bowel type in 70% of cases and colonic in 30%. The elementary lesions found were: transitional zone (36 patients), feces sign (28 patients), beak sign (06 patients), whirlpool sign (11 patients), signs of severity (36 patients). Seventy-two patients received surgery and 04 patients received medical treatment. The preoperative diagnosis was confirmed by surgery in 68 patients. Surgery corrected the diagnosis in 04 cases. Signs of severity were confirmed at surgery in all our patients.
CONCLUSIONS: The CT scan has a major role in the therapeutic choice of AIO. It should be requested in first intention before an occlusive syndrome.
BACKGROUND: L\'occlusion intestinale aiguë (OIA) est un syndrome défini par l\'arrêt du transit intestinal provoqué par un obstacle ou par une paralysie du péristaltisme intestinal. Il s\'agit d\'une urgence diagnostique et thérapeutique. Le scanner multibarrette a révolutionné la prise en charge de cette pathologie, car permettant de répondre aux différentes questions du chirurgien.Le but de notre étude était de décrire les aspects scanographiques des OIA, de déterminer les étiologies et de montrer la place de la TDM dans la prise en charge des OIA.
UNASSIGNED: Il s\'agissait d\'une étude rétrospective descriptive réalisée sur 05ans (Janvier 2010 à décembre 2015) portant sur 81 dossiers de patients colligés dans les services d\'imagerie du CHU Aristide Le Dantec et de l\'hôpital Principal. Les dossiers retenus sont ceux dont le diagnostic était établi à partir de la clinique, de l\'imagerie et/ou non de la chirurgie.
UNASSIGNED: Les occlusions mécaniques représentaient 94,4% (76 cas) et fonctionnelles 5.6% (05 cas).Elles étaient de type grêle dans 70% des cas et colique dans 30%.Les lésions élémentaires mises en évidence étaient : zone transitionnelle (36 patients), signe du fèces (28 patients), signe du bec (06 patients), signe du tourbillon (11 patients), signes de gravité (36 patients). Soixante-douze patients ont bénéficié d\'une chirurgie et 04 patients d\'un traitement médical. Le diagnostic préopératoire était confirmé par la chirurgie chez 68 patients. La chirurgie a redressé le diagnostic dans 04 cas. Les signes de gravité étaient confirmés à la chirurgie chez tous nos patients.
CONCLUSIONS: La TDM occupe une place prépondérante dans le choix thérapeutique des OIA. Elle doit être demandée en première intention devant un syndrome occlusif.

Lewis (LEW) and Wistar Kyoto (WKY) rats of the same major histocompatibility complex (MHC) haplotype (RT.1(l)) display differential susceptibility to adjuvant-induced arthritis (AIA). LEW are susceptible while WKY are resistant to AIA. To gain insights into the mechanistic basis of these disparate outcomes, we compared the gene expression profiles of the draining lymph node cells (LNC) of these two rat strains early (day 7) following a potentially arthritogenic challenge. LNC were tested both ex vivo and after restimulation with the disease-related antigen, mycobacterial heat-shock protein 65. Biotin-labeled fragment cRNA was generated from RNA of LNC and then hybridized with an oligonucleotide-based DNA microarray chip. The differentially expressed genes (DEG) were compared by limiting the false discovery rate to <5% and fold change ≥2.0, and their association with quantitative trait loci (QTL) was analyzed. This analysis revealed overall a more active immune response in WKY than LEW rats. Important differences were observed in the association of DEG with QTL in LEW vs. WKY rats. Both the number of upregulated DEG associated with rat arthritis-QTL and their level of expression were relatively higher in LEW when compared to WKY rat; however, the number of downregulated DEG-associated with rat arthritis-QTL as well as AIA-QTL were found to be higher in WKY than in LEW rats. In conclusion, distinct gene expression profiles define arthritis-susceptible versus resistant phenotype of MHC-compatible inbred rats. These results would advance our understanding of the pathogenesis of autoimmune arthritis and might also offer potential novel targets for therapeutic purposes.