UNASSIGNED:几何灌注不足(GPD)是一种新描述的OCT血管造影(OCTA)参数,可识别假定的视网膜缺血的总面积。我们研究的目的是表征GPD和其他常见定量OCTA参数在黄斑全视野之间的差异,静脉周围区,非增生性糖尿病视网膜病变(DR)的每个临床阶段的小动脉周围区域,并评估超高速采集和平均对所述差异的影响。
未经评估:前瞻性观察性研究。
未经批准:49名患者,其中11人(22.4%)没有DR的迹象,12(24.5%)轻度DR,13(26.5%)中度DR,和13(26.5%)患有严重DR。糖尿病性黄斑水肿患者,增殖性DR,媒体不透明度,头部震颤,排除重叠视网膜疾病或影响OCTA的全身性疾病。
UNASSIGNED:每位患者进行3次OCT血管造影:1次使用SolixFullrange单体积(V1)模式,1使用具有自动平均扫描(V4)的SolixFullrange4体积模式,和1使用AngioVue。
未经证实:全黄斑,小动脉周围,和静脉周围灌注密度(PD),血管长度密度(VLD),血管密度指数,和GPD为浅毛细血管丛(SCP)和深毛细血管丛(DCP)。
未经证实:在没有DR征象的患者中,使用V1和V4的DCP和SCP的静脉周围区域的PD和VLD均显着较低,而使用所有3种设备的DCP和SCP的静脉周围区域的GPD均显着较高。在轻度DR患者中,所有3次测量(PD,VLD,和GPD)在所有3种装置的静脉周围区均存在显着差异。在中度DR患者中,当使用V1和V4测量时,DCP和SCP中的PD和VLD较低。此外,所有3个装置的DCP的静脉周围区GPD较高,而只有V4检测到SCP的差异。在严重的DR中,只有V4在静脉周围区的DCP中检测到较低的PD和VLD和较高的GPD。V4还在SCP中检测到更高的GPD。
UNASSIGNED:几何灌注不足突出显示了在DR所有阶段中黄斑毛细血管缺血的静脉周围位置。在严重DR患者中,只有平均技术允许检测相同的发现。
UNASSIGNED:作者对本文讨论的任何材料都没有专有或商业利益。
UNASSIGNED: Geometric perfusion deficit (GPD) is a newly described OCT angiography (OCTA) parameter identifying the total area of presumed retinal ischemia. The aim of our study is to characterize differences in GPD and other common quantitative OCTA parameters between macular full field, perivenular zones, and periarteriolar zones for each clinical stage of nonproliferative diabetic retinopathy (DR) and to assess the influence of ultrahigh-speed acquisition and averaging on the described differences.
UNASSIGNED: Prospective observational study.
UNASSIGNED: Forty-nine patients, including 11 (22.4%) with no sign of DR, 12 (24.5%) with mild DR, 13 (26.5%) with moderate DR, and 13 (26.5%) with severe DR. Patients with diabetic macular edema, proliferative DR, media opacity, head tremor, and overlapping retinal diseases or systemic diseases influencing OCTA were excluded.
UNASSIGNED: OCT angiography was performed 3 times for each patient: 1 using Solix Fullrange single volume (V1) mode, 1 using Solix Fullrange 4 volumes mode with automatically averaged scan (V4), and 1 using AngioVue.
UNASSIGNED: Full macular, periarteriolar, and perivenular perfusion density (PD), vessel length density (VLD), vessel density index, and GPD for both the superficial capillary plexus (SCP) and deep capillary plexus (DCP).
UNASSIGNED: In patients showing no sign of DR, PD and VLD were significantly lower in the perivenular area in both the DCP and SCP using V1 and V4, whereas GPD was significantly higher in the perivenular zone in the DCP and SCP with all 3 devices. In patients with mild DR, all 3 measurements (PD, VLD, and GPD) were significantly different in the perivenular zone with all 3 devices. In patients with moderate DR, PD and VLD were lower in the DCP and SCP when measured with V1 and V4. Moreover, GPD was higher in the perivenular zone in the DCP with all 3 devices, whereas only V4 detected a difference in the SCP. In severe DR, only V4 detected a lower PD and VLD and a higher GPD in the DCP of the perivenular zone. V4 also detected a higher GPD in the SCP.
UNASSIGNED: Geometric perfusion deficit highlights prevalent perivenular location of macular capillary ischemia in all stages of DR. In severe DR patients, only averaging technology allows detection of the same finding.
UNASSIGNED: The author(s) have no proprietary or commercial interest in any materials discussed in this article.