这篇综述将探讨5'-单磷酸腺苷活化蛋白激酶(AMPK)在肥胖治疗中的作用。医学营养和慢性病,以及它与营养的关系。在文学中,研究AMPK与营养直接关系的研究数量微不足道.出于这个原因,有关该主题的信息已从所有可以通过搜索术语AMPK和疾病访问的研究中汇编,AMPK与健康,AMPK和锻炼,AMPK和营养。可以说,AMPK在许多病理条件下被抑制,例如炎症,糖尿病,衰老和癌症,和AMPK激活在许多疾病,如胰岛素抵抗,糖尿病,肥胖,癌症和老年痴呆症。当检查营养和AMPK之间的关系时,可以看出,食物摄入抑制了AMPK,但尤其是高碳水化合物和高脂肪饮食在这一点上更有效。此外,高果糖玉米饼和长链饱和脂肪酸因食用工业食品而增加,并且经常进餐似乎是AMPK的灭活剂。对于医学营养治疗中的AMPK激活,建议使用晚上禁食和间歇性禁食等方法,考虑到人类的昼夜节律。
This review will examine the role of 5\'-adenosine monophosphate-activated protein kinase (AMPK) in the treatment of obesity, medical nutrition and chronic diseases, and its relationship with nutrition. In the literature, the number of studies examining the direct relationship of AMPK with nutrition is negligible. For this reason, information on the subject has been compiled from all the studies that can be accessed by searching the terms AMPK and disease, AMPK and health, AMPK and exercise, AMPK and nutrition. It can be stated that AMPK is inhibited in many pathological conditions such as inflammation, diabetes, aging and cancer, and AMPK activation has positive effects in many diseases such as insulin resistance, diabetes, obesity, cancer and Alzheimer\'s. When the relationship between nutrition and AMPK is examined, it is seen that food intake inhibits AMPK, but especially high-carbohydrate and fatty diets are more effective at this point. In addition, high fructose corn sirup and long chain saturated fatty acids increased by consumption of industrial foods and frequent meals appear to be an inactivator for AMPK. For AMPK activation in medical nutrition therapy, it is recommended to use methods such as evening fasting and intermittent fasting, taking into account the human circadian rhythm.