Nutritional assessment

营养评估
  • 文章类型: Journal Article
    学校供餐计划如果执行得当,有能力改善学童的营养状况。
    评估尼日利亚翁多州学童的营养状况,因为国家家庭学校供餐计划(NHGSFP)已在该州实施了五年以上。
    这是一项描述性横断面研究。
    共有234名来自公立学校的科目和227名来自私立学校的科目参加了这项研究。他们的平均年龄为8.23±1.92岁。浪费,超重,肥胖,体重不足,发育迟缓的发生率为19.4%,11.4%,0.4%,5.0%,和20.7%的孩子,分别。在公立学校的科目中,发育迟缓(30.3%)和消瘦(23.9%)的患病率更高。发现体重年龄Z评分之间存在显着关联,身高年龄Z分,和BMI-年龄Z-评分和儿童的学校类型(p<0.005)。
    大多数儿童表现出正常生长,其余的人都处于营养不良的两个极端,私立学校的科目似乎有更好的营养状况,尽管没有基线数据来批准这一发现。建议使用当前发现作为基线数据对该主题进行进一步研究。
    UNASSIGNED: The School Feeding Programme if properly executed has the capacity to improve the nutritional status of the school children.
    UNASSIGNED: To assess the nutritional status of school children in Ondo State Nigeria given that the National Home-Grown School Feeding Programme (NHGSFP) has been operational in the state for over five years.
    UNASSIGNED: This was a descriptive cross-sectional study.
    UNASSIGNED: A total of 234 subjects from public schools and 227 subjects from private schools were enrolled in the study. Their mean age was 8.23 ± 1.92 years. Wasting, overweight, obesity, underweight, and stunting were noted in 19.4%, 11.4%, 0.4%, 5.0%, and 20.7% of the children, respectively. The prevalence of stunting (30.3%) and wasting (23.9%) was more among subjects from the public schools. A significant association was found between Weight-for-Age Z-score, Height-for-Age Z-score, and BMI-for-Age Z-score and the children\'s school type (p < 0.005).
    UNASSIGNED: Majority of the children showed normal growth, the rest were in both extremes of malnutrition, the subjects from private schools seem to present better nutritional status, although there is no baseline data to ratify this finding. A further study on this subject using the current finding as a baseline data is recommended.
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  • 文章类型: Journal Article
    神经危重患者经常表现为昏迷,胃轻瘫,和强烈的分解代谢,导致营养不良的风险增加。建立了营养不良诊断的全球领导力倡议(GLIM)标准,以在不同人群中实现一致的营养不良诊断。这项研究旨在验证GLIM标准在神经危重患者中的并发和预测有效性。共有135名参与者从入院到神经关键单元(NCU)直到出院。将GLIM标准与主观全球评估(SGA)进行比较,敏感性为0.95,特异性为0.69.使用复合不良临床结果评估GLIM标准的预测有效性,包括死亡率和各种主要并发症。中度和重度营养不良的调整风险比分别为2.86(95%CI1.45-5.67)和3.88(95%CI1.51-9.94),分别。营养状况指标的变化,包括骨骼肌和腹部脂肪,对61名参与者在入院后7天内进行了研究,以验证GLIM标准对患者接受标准化营养支持的反应的预测能力.GLIM标准对股直肌厚度和中臂肌围的变化具有统计学上显着的预测有效性。总之,GLIM标准对神经危重患者的营养不良诊断具有很高的敏感性,并表现出良好的预测效度.
    Neurocritically ill patients frequently exhibit coma, gastroparesis, and intense catabolism, leading to an increased risk of malnutrition. The Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition was created to achieve a consistent malnutrition diagnosis across diverse populations. This study aimed to validate the concurrent and predictive validity of GLIM criteria in patients with neurocritical illnesses. A total of 135 participants were followed from admission to the neurocritical unit (NCU) until discharge. Comparing GLIM criteria to the Subjective Global Assessment (SGA), sensitivity was 0.95 and specificity was 0.69. Predictive validity of GLIM criteria was assessed using a composite adverse clinical outcome, comprising mortality and various major complications. Adjusted hazard ratios for moderate and severe malnutrition were 2.86 (95% CI 1.45-5.67) and 3.88 (95% CI 1.51-9.94), respectively. Changes in indicators of nutritional status, including skeletal muscle mass and abdominal fat mass, within 7 days of admission were obtained for 61 participants to validate the predictive capability of the GLIM criteria for the patients\' response of standardized nutritional support. The GLIM criteria have a statistically significant predictive validity on changes in rectus femoris muscle thickness and midarm muscle circumference. In conclusion, the GLIM criteria demonstrate high sensitivity for diagnosing malnutrition in neurocritically ill patients and exhibit good predictive validity.
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  • 文章类型: Journal Article
    背景:肝硬化营养不良与不良预后相关,导致高蛋白的指导方针,低钠饮食;然而,没有关于在临床实践中实施饮食教育的指导。
    方法:一项混合方法研究纳入了21名肝硬化患者及其照顾者。对饮食教育和依从性的障碍和促进者进行了半结构化访谈。获得了人口统计学和临床数据,以及饮食依从性的定量测量,包括24小时食物召回和现货尿钠。结合演绎和归纳编码用于识别定性主题,以及对访谈的定量评估。定量数据是使用频率的描述性统计数据报告的,平均和置信区间。
    结果:参与者大多是男性(16/21),平均年龄57.8岁(SE2.8)和MELD-Na9(SE1.2)。4个主题涌现:1。超过50%的参与者和护理人员赞同没有或不充分的饮食教育2。他们报告了饮食依从性对社交生活影响最大的负面经历3。依从性的促进者包括家庭支持的存在和对肝硬化并发症的恐惧4。压倒性的非通用讲义和信息。饮食依从性差,只有一名参与者满足基于食物召回的蛋白质和钠需求。四名坚持<2000毫克钠的参与者每日热量摄入不足。
    结论:饮食教育不足,肝硬化患者对饮食建议的依从性较差。未来的研究应该利用这些障碍和促进因素进行干预发展。
    BACKGROUND: Malnutrition in cirrhosis is associated with poor outcomes, leading to guidelines for a high protein, low sodium diet; however, there is no guidance regarding the implementation of diet education in clinical practice.
    METHODS: A mixed methods study enrolled 21 patients with cirrhosis and their caregivers. Semi-structured interviews on barriers and facilitators of dietary education and adherence were conducted. Demographic and clinical data were obtained, along with quantitative measures of dietary adherence, including 24-h food recall and spot urine sodium. Combined deductive and inductive coding was used to identify qualitative themes, along with a quantitative assessment of interviews. Quantitative data was reported using descriptive statistics with frequencies, mean and confidence intervals.
    RESULTS: Participants were mostly male (16/21) with a mean age 57.8 years (SE 2.8) and MELD-Na 9 (SE 1.2). 4 themes emerged: 1. More than 50% of participants and caregivers endorsed no or inadequate diet education 2. They reported mostly negative experiences with dietary adherence with largest impact on social life 3. Facilitators of adherence included the presence of household support and fear of complications of cirrhosis 4. Overwhelmingly desired non-generic handouts and information. Dietary adherence was poor with only one participant meeting protein and sodium requirements based on food recall. Four participants who adhered to < 2000 mg sodium had inadequate daily caloric intake.
    CONCLUSIONS: Dietary education is inadequate, and adherence to dietary recommendations is poor in patients with cirrhosis. Future studies should use these barriers and facilitators for intervention development.
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  • 文章类型: Journal Article
    背景:术前营养不良是胰腺肿瘤患者接受胰十二指肠切除术的一个重要因素。这项研究的目的是评估术前营养不良与十天内延迟出院之间的关系,以及术前营养不良与术后手术并发症之间的潜在相关性。
    方法:进行了一项回顾性队列研究,从2015年至2022年招募79例良性或恶性头胰腺肿瘤患者的最终样本。使用营养不良通用筛查工具评估营养不良的风险,同时从临床文件中提取住院时间和相关临床数据。
    结果:21.52%的患者术前营养不良风险较高,中度在36.71%,低在41.77%。体重指数(BMI)(p=0.007)和术后并发症(p<0.001)与延迟出院显着相关。在营养不良风险水平和延迟出院之间没有发现统计学上的显着差异(p=0.122),或术后手术并发症(p=0.874)。
    结论:术后并发症和BMI是显著的危险因素。有限的样本量可能损害了同质和重要数据的收集。未来的研究应该评估个性化营养筛查工具的实施。营养评估计划,以及专业卫生专业人员的参与。
    BACKGROUND: Preoperative malnutrition is a significant factor in patients with pancreatic tumors undergoing pancreaticoduodenectomy. The aim of this study was to assess the association between preoperative malnutrition and delayed discharge within a ten-day timeframe and potential correlations between preoperative malnutrition and postoperative surgical complications.
    METHODS: A retrospective cohort study was conducted, recruiting a final sample of 79 patients with benign or malignant cephalic pancreatic tumors from 2015 to 2022. The risk of malnutrition was assessed using the Malnutrition Universal Screening Tool, while length of hospital stay and relevant clinical data were extracted from clinical documentation.
    RESULTS: The preoperative malnutrition risk was high in 21.52% of the sample, moderate in 36.71%, and low in 41.77%. Body mass index (BMI) (p = 0.007) and postoperative surgical complications (p < 0.001) were significantly correlated with delayed discharge. No statistically significant differences were found between levels of malnutrition risk and delayed discharge (p = 0.122), or postoperative surgical complications (p = 0.874).
    CONCLUSIONS: Postoperative complications and BMI emerge as significant risk factors. The limited sample size may have compromised the collection of homogeneous and significant data. Future studies should evaluate the implementation of personalized nutritional screening tools, nutritional assessment plans, and the involvement of specialized health professionals.
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  • 文章类型: Journal Article
    目的:在康复环境中使用推荐的营养评估措施仍不清楚。这项研究探索了使用来自康复康复病房的全国调查数据来识别营养障碍的方法。
    方法:这项横断面研究分析了年度调查,包括识别营养不良的方法,营养不良的风险,Kaifuki(康复期)康复病房的营养过剩。方法识别营养不良和营养不良风险被分组为营养筛查工具(NSTs),营养评估工具(NAT),营养不良诊断标准(DCM),和次优方法(例如,低蛋白血症)。NSTs,NAT,和DCM被进一步归类为“可接受的工具。\"应用可接受的工具之间的关联,基于医院的数据(例如,床的数量),和基于病房的数据(例如,营养状况评估者)通过逻辑回归分析和多重评估进行分析。
    结果:总计,885家拥有Kaifuki康复病房的医院对调查做出了回应,754家医院被纳入分析.注册营养师评估了88%的医院的营养状况,而其他专业人士(例如,护士)评估其余的营养状况。NSTs(例如,迷你营养评估简表),NAT(例如,主观全球评估),DCM(例如,全球营养不良标准领导力倡议),13.1%的人使用了次优工具,5.4%,4.8%,74.6%的病例,分别。大多数医院使用可接受的措施(例如,体重指数)为营养过剩(91.2%)。多元逻辑回归分析显示,注册营养师的评估(调整后的比值比[OR]:2.20.95%置信区间[CI]:1.09-4.45)和医院拥有的食品服务,营养师临床实践时间有限的代表,与实施可接受措施的可能性较低相关(调整后OR:0.64,95CI:0.43-0.97).
    结论:可接受的营养不良措施,包括NST,NAT,DCM,尚未广泛应用于康复康复设置。当注册营养师评估患者的营养状况时,可以促进识别营养不良的推荐工具的实施。
    OBJECTIVE: The utilization of recommended nutritional assessment measures in rehabilitation settings remains unclear. This study explored methods for identifying nutritional disorders using data from a nationwide survey conducted in convalescent rehabilitation wards.
    METHODS: This cross-sectional study analyzed the annual survey, including methods for identifying malnutrition, the risk of malnutrition, and overnutrition in Kaifukuki (convalescent) rehabilitation wards. Methods identifying malnutrition and risk of malnutrition were grouped into nutritional screening tools (NSTs), nutritional assessment tools (NATs), diagnostic criteria for malnutrition (DCM), and suboptimal methods (e.g., hypoalbuminemia). NSTs, NATs, and DCM were further categorized as \"acceptable tools.\" The association between applying acceptable tools, hospital-based data (e.g., the number of beds), and ward-based data (e.g., assessor for nutritional status) was analyzed by logistic regression analysis with multiple imputations.
    RESULTS: In total, 885 hospitals with Kaifukuki rehabilitation wards responded to the survey, and 754 hospitals were included in the analysis. Registered dietitians assessed the nutritional status in 88% of the hospitals, whereas other professionals (e.g., nurses) evaluated the nutritional status in the remainder. NSTs (e.g., Mini Nutritional Assessment Short-Form), NATs (e.g., Subjective Global Assessment), DCM (e.g., Global Leadership Initiative on Malnutrition criteria), and suboptimal tools were used in 13.1%, 5.4%, 4.8%, and 74.6% of cases, respectively. Most hospitals used acceptable measures (e.g., body mass index) for overnutrition (91.2%). Multiple logistic regression analysis showed that assessments by registered dietitians (adjusted odds ratio[OR]: 2.20.95% confidence interval[CI]: 1.09-4.45) and hospital-owned food services, a proxy for limited clinical practice time of dietitians, were associated with a low likelihood of implementing acceptable measures (adjusted OR: 0.64, 95%CI: 0.43-0.97).
    CONCLUSIONS: Acceptable malnutrition measures, including the NSTs, NATs, and DCM, have not been widely applied in convalescent rehabilitation settings. The implementation of recommended tools for identifying malnutrition may be promoted when registered dietitians assess the patients\' nutritional status.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    目的:确定使用人体测量法评估小儿手术患者术前营养状况与术后并发症之间的关系。
    方法:这项前瞻性观察性队列研究包括650名在我们机构接受择期手术的6个月至18年患者。择期手术包括疝切开术等手术,兰花,尿道成形术,膀胱镜检查,PUV激发,肾盂成形术,输尿管再植术,造口形成/闭合,肛门直肠成形术,拉穿,胆总管囊肿切除和修复,VP分流器插入,脂肪脊髓脊膜膨出修复术,脊髓纵裂切除和修复,和囊肿切除。营养状况使用体重Z评分进行标准化,长度,BMI。手术后对患者进行一个月的监测,以发现任何并发症,使用Clavien-Dindo分类法将它们分为五个等级。住院时间和出院后30天内再入院是次要结果。
    结果:研究涉及627名男女患者:350名6个月至5岁的患者(A组),277人年龄在5至18岁之间(B组)。A组浪费率为47.71%,B组浪费率为41.52%。40%的病人发育不良,而B组为83.75%。A组为57.14%的体重不足患者。A组并发症发生率为39.14%,B组并发症发生率为38.99%,营养不良患者术后并发症发生率差异无统计学意义。手术时间延长(>2h)的患者在两组中出现更多的并发症(A组67.2%,B组-82.6%;p<0.0001)。此外,出现并发症的患者住院时间延长(两组p<0.001),再入院率增加(A组p=0.016,B组p=0.008).
    结论:在我们的研究中,A组中有一半的患者和B组中有近三分之二的患者营养不良.基于人体测量参数的术前不良营养状况与术后并发症的增加无关。有必要进行随机对照试验,将基于人体测量的术前营养不良与小儿手术患者的临床结果联系起来,以提供有关该主题的更可靠的信息。
    OBJECTIVE: To determine the relationship between preoperative nutritional status assessed using anthropometric measures and postoperative complications in pediatric surgical patients.
    METHODS: This prospective observational cohort study included 650 patients from 6 months to 18 years undergoing elective surgery at our institution. Elective surgery included procedures such as herniotomy, orchidopexy, urethroplasty, cystoscopy, PUV fulguration, pyeloplasty, ureteric reimplantation, stoma formation/closure, anorectoplasty, pull-through, choledochal cyst excision and repair, VP shunt insertion, lipomyelomeningocele repair, diastematomyelia excision and repair, and cyst excision. Nutritional status was standardized using Z scores for weight, length, and BMI. Patients were monitored for a month following surgery to detect any complications, and they were classified into five grades using the Clavien-Dindo classification. The duration of hospital stays and readmission within 30 days following discharge were secondary outcomes.
    RESULTS: There were 627 patients of both sexes involved in the study: 350 patients aged 6 months to 5 years (Group A), while 277 were aged between 5 and 18 years (Group B). Wasting status was 47.71% in Group A and 41.52% in Group B. In Group A, 40% of patients were stunted, while 83.75% were in Group B. Group A had 57.14% underweight patients. The complication rate was 39.14% in Group A and 38.99% in Group B. The incidence of postoperative complications was not significantly different in malnourished patients. The patients with prolonged duration of surgery (> 2 h) developed more complications in both groups (Group A-67.2%, Group B-82.6%; p < 0.0001). In addition, the patients who experienced complications had lengthier hospital stays (p < 0.001 in both groups) and increased readmission rates (p = 0.016 in Group A and p = 0.008 in Group B).
    CONCLUSIONS: In our study, half of the patients in Group A and nearly two-third in Group B were malnourished. The preoperative poor nutritional status based on anthropometric parameters is not associated with increased postoperative complications. Randomized control trials linking preoperative malnutrition based on anthropometric measures and clinical outcomes in pediatric surgery patients are necessary to provide more robust information on this subject.
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  • 文章类型: Journal Article
    目的:营养不良在肾衰竭患者中非常普遍。由于体重不能反映身体成分,需要其他方法来确定肌肉质量,通常通过无脂质量(FFM)估计。生物阻抗谱(BIS)经常用于监测肾衰竭患者的身体成分。不幸的是,BIS来源的瘦组织质量(LTMBIS)不适合与FFM诊断营养不良的临界值进行比较。或计算膳食蛋白质需求。假设,FFM可以从BIS数据(FFMBIS)导出。本研究旨在将FFMBIS和LTMBIS与计算机断层扫描(CT)衍生的FFM(FFMCT)进行比较。其次,我们旨在探讨使用不同方法对计算蛋白质需求的影响。
    方法:在L3水平分析60例CKD4-5期患者的CT扫描肌肉横截面积,转换为FFMCT。计算Spearman等级相关系数和95%一致极限(LoA)以比较FFMBIS和LTMBIS与FFMCT。根据FFMCT确定饮食蛋白质需求,FFMBIS和调整体重。超过10%的偏差被认为是临床相关的。
    结果:FFMCT与FFMBIS相关性最强(r=0.78,p<0.001),男性(r=0.72,p<0.001)和女性(r=0.60,p<0.001)。FFMBIS和FFMCT之间的平均差为-0.54kg(LoA:-14.88至13.7kg,p=0.544)。在LTMBIS和FFMCT之间,-12.2kg的平均差很明显(LoA:-28.7至4.2kg,p<0.001)。使用FFMCT作为参考,FFMBIS最佳预测蛋白质需求。根据FFMBIS和FFMCT的蛋白质需求之间的平均差异在男性中为-0.7±9.9克,在女性中为-0.9±10.9克。
    结论:FFMBIS在群体水平上与FFMCT有很好的相关性,但个体内部仍然存在很大差异。不出所料,在计算的蛋白质需求中观察到较大的临床相关差异.
    OBJECTIVE: Malnutrition is highly prevalent in patients with kidney failure. Since body weight does not reflect body composition, other methods are needed to determine muscle mass, often estimated by fat-free mass (FFM). Bioimpedance spectroscopy (BIS) is frequently used for monitoring body composition in patients with kidney failure. Unfortunately, BIS-derived lean tissue mass (LTMBIS) is not suitable for comparison with FFM cut-off values for the diagnosis of malnutrition, or for calculating dietary protein requirements. Hypothetically, FFM could be derived from BIS data (FFMBIS). This study aims to compare FFMBIS and LTMBIS with computed tomography (CT) derived FFM (FFMCT). Secondarily, we aimed to explore the impact of using different methods on calculated protein requirements.
    METHODS: CT scans of 60 patients with CKD stage 4-5 were analyzed at the L3 level for muscle cross-sectional area, which was converted to FFMCT. Spearman rank correlation coefficient and 95% limits of agreement (LoA) were calculated to compare FFMBIS and LTMBIS with FFMCT. Dietary protein requirements were determined based on FFMCT, FFMBIS and adjusted body weight. Deviations over 10% were considered clinically relevant.
    RESULTS: FFMCT correlated most strongly with FFMBIS (r=0.78, p<0.001), in males (r=0.72, p<0.001) and in females (r=0.60, p<0.001). A mean difference of -0.54 kg was found between FFMBIS and FFMCT (LoA: -14.88 to 13.7 kg, p=0.544). Between LTMBIS and FFMCT a mean difference of -12.2 kg was apparent (LoA: -28.7 to 4.2 kg, p<0.001). Using FFMCT as a reference, FFMBIS best predicted protein requirements. The mean difference between protein requirements according to FFMBIS and FFMCT was -0.7 ± 9.9 grams in males and -0.9 ± 10.9 grams in females.
    CONCLUSIONS: FFMBIS correlates well with FFMCT at a group level, but still shows large variation within individuals. As expected, large clinically relevant differences were observed in calculated protein requirements.
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  • 文章类型: Journal Article
    使用适当的筛查工具迅速识别住院患者的营养不良至关重要。我们研究的目的是比较住院患者中关于新的GLIM营养不良标准的最推荐的筛查工具。
    在这项横断面研究中,我们分析了2022年8月至2023年5月期间在Bandrma培训和研究医院接受住院治疗的1,397例患者的数据,以评估和比较他们的营养不良.在Bandrma培训与研究医院的内部和外科诊所接受住院治疗的患者。除了GLIM标准,我们使用了营养筛查和评估工具,如NRS-2002、MST、GMS,必须,SNAQGLIM标准被认为是评价敏感性和特异性的金标准。五种筛查工具的受试者工作特征(ROC)曲线也用于评估准确区分营养不良风险患者的能力。
    不同筛查工具在检测营养不良方面的性能比较表明,尽管GMS的灵敏度最高(87.40%),NRS-2002的特异性最高(91.70%)。曲线下面积(AUC)值表明NRS-2002、MST、GMS,SNAQ非常出色,MUST的预测价值良好(p<0.001)。虽然GLIM标准尤其似乎是检测住院患者营养不良的有效工具,其他筛查工具也有助于评估营养不良风险.
    我们强调了MST与GLIM标准的一致性,强调多学科方法对早期营养不良诊断的重要性。有营养不良风险的患者可以通过适当的筛查工具更快更准确地诊断出来,并且可以提高治疗的有效性。
    UNASSIGNED: The prompt identification of malnutrition among hospitalized patients using the appropriate screening tool is paramount. The objective of our study is to compare the most recommended screening tools concerning the new GLIM criteria for malnutrition in hospitalized patients.
    UNASSIGNED: In this cross-sectional study, we analyzed the data on 1,397 patients receiving inpatient treatment at Bandırma Training and Research Hospital between August 2022 and May 2023 to assess and compare malnutrition in them. Patients who received inpatient treatment in the internal and surgical clinics of Bandırma Training and Research Hospital. In addition to the GLIM criteria, we used nutritional screening and assessment tools such as NRS-2002, MST, GMS, MUST, and SNAQ. The GLIM criteria were considered the gold standard for the evaluation of sensitivity and specificity. Receiver operating characteristic (ROC) curves for the five screening tools were also used to assess the ability to distinguish malnutrition-risk patients accurately.
    UNASSIGNED: The comparison of the performances of different screening tools in detecting malnutrition demonstrated that while the GMS had the highest sensitivity (87.40%), the NRS-2002 had the highest specificity (91.70%). The area under the Curve (AUC) value indicated that the predictive values of the NRS-2002, MST, GMS, and SNAQ were excellent, and the predictive value of the MUST was good (p < 0.001). While the GLIM criteria in particular appear to be an effective tool for detecting malnutrition in hospitalized individuals, other screening tools are also useful in assessing their malnutrition risk.
    UNASSIGNED: We emphasized MST\'s alignment with GLIM criteria, underscoring the importance of a multidisciplinary approach for early malnutrition diagnosis. Patients at risk of malnutrition can be diagnosed more quickly and accurately with appropriate screening tools and the effectiveness of treatments can be increased.
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  • 文章类型: Journal Article
    目的:肌肉丧失是营养不良的表型标准之一,在肝硬化患者中非常普遍,并与不良结果相关。中臂肌围(MAMC)估计骨骼肌质量,在液体超负荷的情况下特别有用。本研究旨在为肝硬化患者提出MAMC截止点,并证明其与1年死亡率的关联。
    方法:这是对来自巴西五个参考中心的队列数据库的分析,其中包括年龄≥18岁的肝硬化住院患者和门诊患者。获得的营养变量是MAMC(n=1075)和主观总体评估(n=629)。我们根据主观总体评估建立了按性别分层的MAMC分界点,作为营养不良诊断的参考标准。考虑到敏感性,特异性,和Youden指数。使用校正后的Cox回归模型来检验MAMC截止点与1年死亡率的相关性。
    结果:我们纳入了1075例肝硬化患者,平均年龄54.8±11.3岁;70.4%(n=757)男性。大多数患者患有酒精性肝硬化(47.1%,n=506),并归类为Child-PughB(44.7%,n=480)。中度和重度耗竭的MAMC截止点≤21.5cm和≤24.2cm;男女≤20.9cm和≤22.9cm,分别。根据这些临界点,13.8%(n=148)和35.1%(n=377)的患者有中度或重度MAMC耗竭,分别。1年死亡率为17.3%(n=186)。在根据性别调整后的多变量分析中,年龄,MELD-Na,和Child-Pugh分数,MAMC严重耗竭是1年死亡率增加的独立危险因素(HR:1.71,95%CI:1.24-2.35,P<0.001).MAMC值每增加1cm,1年死亡风险降低11%(HR:0.89,95%CI:0.85-0.94,P<0.001)。
    结论:根据新的分界点分类的低MAMC可预测肝硬化患者的死亡风险,可用于临床实践。
    OBJECTIVE: Muscle loss is one of the phenotypic criteria of malnutrition, is highly prevalent in patients with cirrhosis, and is associated with adverse outcomes. Mid-arm muscle circumference (MAMC) estimates the skeletal muscle mass and is especially helpful in cases of fluid overload. This study aimed to propose MAMC cutoff points for patients with cirrhosis and demonstrate its association with 1-year mortality.
    METHODS: This is an analysis of cohort databases from five reference centers in Brazil that included inpatients and outpatients with cirrhosis aged ≥18 y. The nutritional variables obtained were the MAMC (n = 1075) and the subjective global assessment (n = 629). We established the MAMC cutoff points stratified by sex based on the subjective global assessment as a reference standard for malnutrition diagnosis, considering the sensitivity, specificity, and Youden index. An adjusted Cox regression model was used to test the association of MAMC cutoff points and 1-year mortality.
    RESULTS: We included 1075 patients with cirrhosis, with a mean age of 54.8 ± 11.3 y; 70.4% (n = 757) male. Most patients had alcoholic cirrhosis (47.1%, n = 506) and were classified as Child-Pugh B (44.7%, n = 480). The MAMC cutoff points for moderate and severe depletion were ≤21.5 cm and ≤24.2 cm; ≤20.9 cm and ≤22.9 cm for women and men, respectively. According to these cutoff points, 13.8% (n = 148) and 35.1% (n = 377) of the patients had moderate or severe MAMC depletion, respectively. The 1-year mortality rate was 17.3% (n = 186). In the multivariate analysis adjusted for sex, age, MELD-Na, and Child-Pugh scores, a severe depletion in MAMC was an independent increased risk factor for 1-year mortality (HR: 1.71, 95% CI: 1.24-2.35, P < 0.001). Each increase of 1 cm in MAMC values was associated with an 11% reduction in 1-year mortality risk (HR: 0.89, 95% CI: 0.85-0.94, P < 0.001).
    CONCLUSIONS: Low MAMC classified according to the new cutoff points predicts mortality risk in patients with cirrhosis and could be used in clinical practice.
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