Nutrition therapy

营养治疗
  • 文章类型: Journal Article
    目的:研究目的是确定营养护理过程(NCP)的水平和障碍,个性化营养支持的实用方法。
    方法:来自急性护理医院的注册营养师(RD)代表回答了我们全国性的基于网络的问卷(4月至6月,2023)确定筛查的实施状况,评估,干预(包括规划),和监测(NCP的组成部分)。
    结果:在联系的5,378个机构中,905(16.8%)回答。对于筛选,80.0%筛查所有住院患者:主要负责人为RD(57.6%);最常用的筛查工具为主观整体评估(SGA)(49.2%)。对于评估,66.1%评估了所有住院患者:食物摄入量(93.3%)评估最多,而肌肉质量和力量(13.0%,8.8%)评价最低。对于干预,43.9%的人在入院后48小时内这样做:口服营养补充剂(92.9%)是最常见的RD干预措施,而肠外营养(29.9%)的使用较少。对于监控,18.5%的机构监测频率≥3次/周,而23.0%的机构监测严重营养不良患者每周少于一次。能量和蛋白质摄入量(93.7%,监测最多的是84.3%),监测较少的是脂质摄入量(30.1%)。
    结论:NCP的障碍包括低效的人员配备系统和不合适的筛查工具,患者定位不准确,评估中缺乏重要的评估项目,干预中的时间安排延迟和内容不完整,监测频率不足,缺乏重要的评价项目。急性护理普通病房的RD人员增加,广泛的NCP指导手册,关于营养管理中使用的工具和评估项目的教育是可能的解决方案。
    OBJECTIVE: Study aim was to determine the levels and barriers of the Nutrition Care Process (NCP), a practical method of individualized nutrition support.
    METHODS: Delegate of registered dietitians (RDs) from acute-care hospitals answered our nationwide web-based questionnaire (April-June, 2023) to determine the implementation status of screening, assessment, intervention (including planning), and monitoring (components of the NCP).
    RESULTS: Of 5,378 institutions contacted, 905 (16.8%) responded. For Screening, 80.0% screened all inpatients: primary personnel in charge were RDs (57.6%); the most used screening tool was Subjective Global Assessment (SGA) (49.2%). For Assessment, 66.1% assessed all inpatients: food intake (93.3%) was most evaluated whereas muscle mass and strength (13.0%, 8.8%) were least evaluated. For Intervention, 43.9% did so within 48h of hospital admission: oral nutritional supplement (92.9%) was the most common RDs intervention and parenteral nutrition (29.9%) was used less. For Monitoring, 18.5% of institutions had monitoring frequency of ≥ 3 times/week whilst 23.0% had monitoring less than once a week for severely malnourished patients. Energy and protein intake (93.7%, 84.3%) were most monitored and lipid intake (30.1%) was less monitored.
    CONCLUSIONS: Barriers of NCP included inefficient staffing systems and unsuitable tools in Screening, inaccurate patient targeting and lack of important evaluation items in Assessment, delayed timing and incomplete contents in Intervention, and inadequate fre-quency and lack of important evaluation items in Monitoring. An increase in RDs staffing in acute-care general wards, widespread NCP instruction manuals, and education about the tools and evaluation items utilized in nutritional management are possible solutions.
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  • 文章类型: Journal Article
    对于营养不良的老年人,从医院到家庭的护理过渡是一个风险升高的时期;然而,描述现有做法的数据最少。这项研究旨在描述澳大利亚一家公立三级医院向老年人提供的营养护理流程的转变。2022年7月至10月进行的回顾性图表审计包括年龄较大(≥65岁),营养不良的成年人出院独立生活。饮食护理实践(从住院到出院后六个月)进行了描述性报道。在3466次连续录取中,345(10%)有营养师记录的营养不良诊断,并包括在分析中。每次入院的饮食访问的中位数为2.0(IQR1.0-4.0)。以营养为重点的出院计划的制定和记录不一致。只有10%的患者在电子出院摘要中记录了营养护理建议。46%的患者接受出院后口服营养补充剂,并被34%的患者接受。而只有23%的人在出院后6个月内接受了营养学的随访。大多数由营养师就诊并被诊断为营养不良的患者似乎在从医院到家庭的过渡中迷失了方向。需要不断开展工作,以探索这一弱势群体出院后营养护理的决定因素。
    Care transitions from hospital to home for older adults with malnutrition present a period of elevated risk; however, minimal data exist describing the existing practice. This study aimed to describe the transition of nutrition care processes provided to older adults in a public tertiary hospital in Australia. A retrospective chart audit conducted between July and October 2022 included older (≥65 years), malnourished adults discharged to independent living. Dietetic care practices (from inpatient to six-months post-discharge) were reported descriptively. Of 3466 consecutive admissions, 345 (10%) had a diagnosis of malnutrition documented by the dietitian and were included in the analysis. The median number of dietetic visits per admission was 2.0 (IQR 1.0-4.0). Nutrition-focused discharge plans were inconsistently developed and documented. Only 10% of patients had nutrition care recommendations documented in the electronic discharge summary. Post-discharge oral nutrition supplementation was offered to 46% and accepted by 34% of the patients, while only 23% attended a follow-up appointment with dietetics within six months of hospital discharge. Most patients who are seen by dietitians and diagnosed with malnutrition appear lost in transition from hospital to home. Ongoing work is required to explore determinants of post-discharge nutrition care in this vulnerable population.
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  • 文章类型: Journal Article
    消极的习惯在当代社会中持续存在,有时会导致超重或身体形象恶化。这项研究旨在评估营养和心理社会干预作为跨学科方法的一部分的适用性,以改善对身体形象的感知并增加超重或肥胖个体的自尊。共有55名参与者(25名男性和30名女性)参加了这项准实验性干预研究。测量作为非卧床治疗的一部分,以获得体重值,自尊,和身体形象感知使用罗森伯格量表和身体自尊量表。在干预结束和一年后,体重平均减少了13.4公斤,积极的自我形象感知从预测时的平均值88.73提高到随访时的平均值148.02,自尊从平均22.6提高到32.6。这些都是统计学上显著的变化(p<0.001)。该模型在减轻重量方面是有效的,同时提高了自尊水平和对身体形象的良好感知。
    Negative habits persist in contemporary society that can sometimes result in overweight or the deterioration of body image. This study aimed to assess the suitability of a nutritional and psychosocial intervention as part of an interdisciplinary approach to improve the perception of body image and increase the self-esteem of individuals who are overweight or obese. A total of 55 participants (25 men and 30 women) were included in this quasi-experimental intervention study. Measurements were taken as part of an ambulatory treatment to obtain values for weight, self-esteem, and body image perception using the Rosenberg scale and the Body Self-Esteem scale. At the end of the intervention and after one year, the weight reductions reached an average of 13.4 kg, positive self-image perception improved from a mean of 88.73 at pretest to 148.02 at follow-up, and self-esteem improved from a mean of 22.6 to 32.6. These were all statistically significant changes (p < 0.001). The model is effective in terms of weight reduction, together with improved levels of self-esteem and favorable perceptions of body image.
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  • 文章类型: Journal Article
    背景:临床营养学家在临床实践中负责营养治疗,这显著提高了患者的营养状况。本研究旨在开发和验证能力评估量表,以有效评估临床营养师的能力。方法:基于冰山模型编制临床营养师胜任力评价量表,利用文献综述,半结构化面试,和Delphi方法。采用层次分析法(AHP)计算各指标的权重,并通过问卷调查证实了量表的效度和信度。结果:临床营养师胜任力评价量表包括五项主要指标,十二个二级指标,和六十六项三级指标。主要指标,包括专业理论知识,专业实践技能,人文实践能力,人际沟通能力,和专业发展能力,各自的权重为0.2168、0.2120、0.2042、0.2022和0.1649。量表五个维度的Cronbachα系数分别为0.970、0.978、0.969、0.962和0.947。探索性因子分析的结果表明,满足因子分析的前提条件。此外,Bartlett球形度检验的显著性水平为p<0.001,证实了该量表的信度和效度。结论:本研究编制的临床营养师胜任力评价量表具有较高的科学信度和效度,为临床营养师的培训和评估提供了评估标准。
    Background: Clinical nutritionists are responsible for nutritional therapy in clinical practice, which significantly enhances patients\' nutritional status. This study aims to develop and validate a competency evaluation scale to effectively assess the abilities of clinical nutritionists. Methods: The competency evaluation scale for clinical nutritionists was developed based on the iceberg model, utilizing literature review, semi-structured interviews, and the Delphi method. The weights of each indicator were calculated using the Analytic Hierarchy Process (AHP), and the validity and reliability of the scale were confirmed through questionnaire surveys. Results: The competency evaluation scale of clinical nutritionists comprised five primary indicators, twelve secondary indicators, and sixty-six tertiary indicators. The primary indicators, including professional theoretical knowledge, professional practical skills, humanistic practice ability, interpersonal communication ability, and professional development capability, have respective weights of 0.2168, 0.2120, 0.2042, 0.2022, and 0.1649. The Cronbach\'s α coefficients of the five dimensions of the scale were 0.970, 0.978, 0.969, 0.962, and 0.947, respectively. The results of the Exploratory Factor Analysis showed that the prerequisites for factor analysis were satisfied. Additionally, Bartlett\'s test of sphericity yielded a significance level of p < 0.001, confirming the scale\'s reliability and validity. Conclusions: The competency evaluation scale for clinical nutritionists developed in this study is of high scientific reliability and validity, which provides assessment criteria for the training and assessment of clinical nutritionists.
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  • 文章类型: Journal Article
    本研究旨在回顾现有文献中关于老年癌症患者化疗期间口服营养补充剂(ONS)的影响。截至2024年3月,在电子数据库中搜索相关研究。使用Cochrane工具评估纳入研究的偏倚风险。符合条件的研究包括随机,prospective,和回顾性研究评估ONS在老年(中位年龄>65岁)癌症患者化疗期间的效果。有关化疗依从性的数据,毒性,总生存率,并提取营养状况。总共有十项研究,涉及1123名患者,包括在内。由于结果的稀缺性和异质性,未对结果进行荟萃分析。一些ONS与化疗副作用的发生率降低有关,尤其是口腔粘膜炎,改善营养状况。关于ONS对化疗依从性或总生存期的影响的证据有限或没有。调查了各种类型的ONS,包括量身定制的营养咨询的多模式干预,乳清蛋白补充剂,氨基酸补充剂(包括免疫营养补充剂),和鱼油富含omega-3的补充剂。ONS显示出减少化疗副作用和改善老年癌症患者营养状况的希望。但需要进一步的研究来探讨其对化疗依从性和总生存期的影响.未来的研究应该同时考虑实际年龄和虚弱标准,考虑到饮食习惯,并使用特定的营养评估,如生物电阻抗分析。
    This study aims to review existing literature on the effect of oral nutritional supplements (ONSs) during chemotherapy in older cancer patients. Electronic databases were searched for relevant studies up to March 2024. The risk of bias in the included studies was evaluated using the Cochrane tool. Eligible studies included randomized, prospective, and retrospective studies evaluating the effect of ONSs in elderly (median age > 65 years) cancer patients during chemotherapy. Data regarding chemotherapy adherence, toxicity, overall survival, and nutritional status were extracted. A total of ten studies, involving 1123 patients, were included. A meta-analysis of the results was not conducted due to the scarcity and heterogeneity of results. Some ONSs were associated with reduced incidence of chemotherapy side-effects, particularly oral mucositis, and improved nutritional status. There was limited or no evidence regarding the impact of ONSs on chemotherapy adherence or overall survival. Various types of ONS were investigated, including multimodal intervention with tailored nutritional counseling, whey protein supplements, amino acids supplements (including immune nutrition supplements), and fish oil omega-3-enriched supplements. ONSs showed promise in reducing chemotherapy side-effects and improving nutritional status in older cancer patients, but further studies are needed to explore their efficacy on chemotherapy adherence and overall survival. Future research should consider both chronological age and frailty criteria, account for dietary habits, and use specific nutritional assessment like Bioelectrical Impedance Analysis.
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  • 文章类型: Journal Article
    背景:充足的营养对于危重病后的康复很重要。即便如此,我们对重症监护病房(ICU)出院后患者营养摄入的了解很少。
    目的:我们旨在探索从ICU转移到普通病房的ICU患者的营养计划和营养摄入。
    方法:回顾性质量保证研究。
    方法:2021年5月至8月,将ICU的成年患者转移到哥本哈根大学医院-Herlev的普通病房。主要结果如下:在ICU转移当天制定营养计划。营养计划的定义如下:(i)对能量和蛋白质需求的个人评估;(ii)摄入量,记录为达到的能量和蛋白质需求百分比;(iii)规定的营养类型。如果使用肠内或肠胃外营养;(iv)规定的剂量;和(v)规定的产品。次要结果如下:从ICU转移前-1天到ICU转移后第1天和第3天达到的能量和蛋白质需求百分比。
    结果:我们包括57例患者;平均年龄为64岁(±11.1);43例(75%)患者为男性;ICU住院时间中位数为6天(四分位距:3-11)。根据列出的标准,一名(2%)患者有完整的营养计划。从ICU出院前一天到第二天,患者需求满足的中位数百分比显着下降(能量:从94%到30.5%;p=0.0051;蛋白质:从73%到27.5%;p=0.0117)。从ICU转移后的第1天到第3天,满足要求的百分比下降保持不变。
    结论:结论:从ICU转至普通病房时,很少有患者有营养计划.ICU出院后,普通病房的能量和蛋白质需求满足的百分比显着下降,并且在前3天仍然不足。
    BACKGROUND: Adequate nutrition is important for recovery after critical illness. Even so, our knowledge of patients\' nutritional intake after intensive care unit (ICU) discharge is scarce.
    OBJECTIVE: We aimed to explore nutritional planning and achieved nutritional intake in ICU patients who transfer from the ICU to general wards.
    METHODS: A retrospective quality assurance study.
    METHODS: adult ICU patients transferring to a general ward at Copenhagen University Hospital-Herlev from May to August 2021. Primary outcomes were as follows: having a nutritional plan on the day of ICU transfer. A nutritional plan was defined as follows: (i) individual assessment of energy and protein requirement; (ii) intake, documented as achieved percentage of energy and protein requirements; (iii) prescribed type of nutrition. If using enteral or parenteral nutrition; (iv) the prescribed doses; and (v) the prescribed product. Secondary outcomes were as follows: achieved percentage of energy and protein requirements from day -1 before ICU transfer until day +1 and day +3 after ICU transfer.
    RESULTS: We included 57 patients; the mean age was 64 years (±11.1); 43 (75%) patients were male; the median ICU stay was 6 days (interquartile range: 3-11). One (2%) patient had a full nutritional plan according to listed criteria. Patients\' median percentage of requirements met declined significantly from the day before to the day after ICU discharge (energy: from 94% to 30.5%; p = 0.0051; protein: from 73% to 27.5%; p = 0.0117). The decline in percentage of requirements met remained unchanged from day 1 to 3 after ICU transfer.
    CONCLUSIONS: In conclusion, few patients had a nutritional plan when transferring from the ICU to a general ward. After ICU discharge, percentage of energy and protein requirements met declined significantly and remained insufficient during the first 3 days at the general ward.
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  • 文章类型: Journal Article
    目的:住院患者常有急性肾脏病(AKD)或慢性肾脏病(CKD),具有重要的代谢和营养后果。此外,如果开始肾脏替代疗法(KRT),对营养需求的可能影响不容忽视。在这方面,本指南旨在为KD住院患者的临床营养提供循证建议.
    方法:使用ESPEN指南的标准操作程序。临床问题以PICO格式定义,并在需要时组织在子主题中,以及在非PICO问题中更一般的主题。文献检索是从1月1日起,1999年至1月1日,2020年。每个问题都导致一个或多个建议/声明和相关评论。现有证据被分级,以及在多阶段共识进程中制定和商定的建议和声明。
    结果:本指南提供了32项基于证据的建议和8项声明,定义如何评估营养状况,如何定义有风险的患者,如何选择喂养路线,以及如何将营养与KRT整合。在最后的网上投票中,至少84%的建议和100%的声明达成了强烈共识。
    结论:住院患者中KD的存在确定了一组高度异质性的受试者,这些受试者的营养需求和摄入量差异很大。考虑到与这种临床状况相关的高营养风险,一种由营养状况评估和监测组成的个性化方法,经常评估营养需求,应计划与KRT的仔细整合,以避免喂养不足和过度喂养。提出了切实可行的建议和声明,旨在确定在这种患者环境中营养支持个性化的日常临床实践建议。还确定了缺乏或没有证据的文献领域,因此需要进一步的基础或临床研究。
    OBJECTIVE: Hospitalized patients often have acute kidney disease (AKD) or chronic kidney disease (CKD), with important metabolic and nutritional consequences. Moreover, in case kidney replacement therapy (KRT) is started, the possible impact on nutritional requirements cannot be neglected. On this regard, the present guideline aims to provide evidence-based recommendations for clinical nutrition in hospitalized patients with KD.
    METHODS: The standard operating procedure for ESPEN guidelines was used. Clinical questions were defined in both the PICO format, and organized in subtopics when needed, and in non-PICO questions for the more general topics. The literature search was from January 1st, 1999 until January 1st, 2020. Each question led to one or more recommendation/statement and related commentaries. Existing evidence was graded, as well as recommendations and statements were developed and agreed upon in a multistage consensus process.
    RESULTS: The present guideline provides 32 evidence-based recommendations and 8 statements, defining how to assess nutritional status, how to define patients at risk, how to choose the route of feeding, and how to integrate nutrition with KRT. In the final online voting, a strong consensus was reached in 84% at least of recommendations and 100% of statements.
    CONCLUSIONS: The presence of KD in hospitalized patients identifies a highly heterogeneous group of subjects with widely varying nutrient needs and intakes. Considering the high nutritional risk related with this clinical condition, an individualized approach consisting of nutritional status evaluation and monitoring, frequent evaluation of nutritional requirements, and careful integration with KRT should be planned to avoid both underfeeding and overfeeding. Practical recommendations and statements were developed, aiming at defining suggestions for everyday clinical practice in the individualization of nutritional support in this patient setting. Literature areas with scarce or without evidence were also identified, thus requiring further basic or clinical research.
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  • 文章类型: Systematic Review
    背景:中风患者经常面临严重影响其日常生活的残疾。营养不良是这些患者的常见问题,营养不良会严重影响卒中后的功能恢复。因此,营养治疗对于管理卒中结局至关重要.然而,它对残疾的影响,日常生活活动(ADL),和其他关键成果尚未得到充分探索。
    目的:评价营养治疗对脑卒中后患者减少残疾和改善ADL的作用。
    方法:我们搜索了Cochrane卒中组的试验记录,中部,MEDLINE(自1946年起)Embase(自1974年起),CINAHL(自1982年起),和AMED(从1985年起)至2024年2月19日。我们还搜索了试验和研究登记处(ClinicalTrials.gov,世界卫生组织国际临床试验注册平台)和参考文章列表。
    方法:我们纳入了随机对照试验(RCT),比较了营养治疗与安慰剂,日常护理,或中风后的一种营养疗法。营养治疗被定义为补充营养,包括能量,蛋白质,氨基酸,脂肪酸,维生素,矿物,通过口头,肠内,或肠胃外方法。作为一个比较器,一种营养疗法是指所有形式的营养疗法,排除定义用于干预组的特定营养疗法.
    方法:我们使用Cochrane的Screen4Me工作流程来评估初始搜索结果。两位综述作者独立筛选了符合纳入标准的参考文献,提取的数据,并使用GRADE方法评估偏倚风险和证据的确定性。我们计算了连续数据的平均差(MD)或标准化平均差(SMD)和二分数据的比值比(OR),95%置信区间(CI)。我们使用I2统计量评估异质性。主要结果是残疾和ADL。我们还评估了步态,营养状况,全因死亡率,生活质量,手和腿的肌肉力量,认知功能,物理性能,中风复发,吞咽功能,神经损伤,和并发症(不良事件)的发展作为次要结局。
    结果:我们确定了52个合格的RCT,涉及11,926名参与者。在急性期进行了36项研究,10在亚急性期,三个在急性期和亚急性期,还有三个在慢性期。23项研究包括缺血性中风患者,其中三名包括出血性中风患者,其中3例包括蛛网膜下腔出血(SAH)患者,23例包括缺血性或出血性卒中患者,包括SAH.有25种类型的营养补充剂用作干预措施。评估残疾和ADL作为结果的研究数量分别为9项和17项。对于使用口服能量和蛋白质补充剂的干预,这是这篇综述的主要干预措施,纳入了六项研究。七个结果的结果集中在(残疾,ADL,体重变化,全因死亡率,步态速度,生活质量,和并发症发生率(不良事件))如下:当“良好状态”定义为mRS评分为0至2时,没有证据表明减少残疾的差异(对于“良好状态”:OR0.97,95%CI0.86至1.10;1个RCT,4023名参与者;低确定性证据)。口服能量和蛋白质补充剂可以改善ADL,如FIM运动评分增加所示,但证据非常不确定(MD8.74,95%CI5.93至11.54;2项随机对照试验,165名参与者;非常低的确定性证据)。口服能量和蛋白质补充剂可能会增加体重,但证据非常不确定(MD0.90,95%CI0.23至1.58;3项RCT,205名参与者;非常低的确定性证据)。没有证据表明在降低全因死亡率方面存在差异(OR0.57,95%CI0.14至2.28;2项随机对照试验,4065名参与者;低确定性证据)。对于步态速度和生活质量,没有确定研究。关于并发症(不良事件)的发生率,没有证据表明感染的发生率有差异,包括肺炎,尿路感染,和败血症(OR0.68,95%CI0.20至2.30;1个RCT,42名参与者;非常低的确定性证据)。与常规治疗相比,干预措施与腹泻发生率增加相关(OR4.29,95%CI1.98至9.28;1RCT,4023名参与者;低确定性证据)和高血糖或低血糖的发生(OR15.6,95%CI4.84至50.23;1个RCT,4023名参与者;低确定性证据)。
    结论:我们不确定营养治疗的效果,包括口服能量和蛋白质补充剂以及本综述中确定的其他补充剂,关于减少中风后患者的残疾和改善ADL。在纳入的研究中,评估了各种营养干预措施的结果。几乎所有研究的样本量都很小。这导致了进行荟萃分析的挑战,并降低了证据的准确性。此外,大多数研究都存在偏见风险,特别是在没有盲目性和不清楚的信息方面。关于不良事件,口服能量和蛋白质补充剂的干预与较高数量的不良事件相关,比如腹泻,高血糖症,和低血糖,与通常的护理相比。然而,证据质量很低。鉴于我们审查中大多数证据的确定性较低,需要进一步的研究。未来的研究应该集中在有针对性的营养干预,以减少残疾和改善ADL的理论基础上,中风后的人,有必要改进方法和报告。
    Stroke patients often face disabilities that significantly interfere with their daily lives. Poor nutritional status is a common issue amongst these patients, and malnutrition can severely impact their functional recovery post-stroke. Therefore, nutritional therapy is crucial in managing stroke outcomes. However, its effects on disability, activities of daily living (ADL), and other critical outcomes have not been fully explored.
    To evaluate the effects of nutritional therapy on reducing disability and improving ADL in patients after stroke.
    We searched the trial registers of the Cochrane Stroke Group, CENTRAL, MEDLINE (from 1946), Embase (from 1974), CINAHL (from 1982), and AMED (from 1985) to 19 February 2024. We also searched trials and research registries (ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform) and reference lists of articles.
    We included randomised controlled trials (RCTs) that compared nutritional therapy with placebo, usual care, or one type of nutritional therapy in people after stroke. Nutritional therapy was defined as the administration of supplemental nutrients, including energy, protein, amino acids, fatty acids, vitamins, and minerals, through oral, enteral, or parenteral methods. As a comparator, one type of nutritional therapy refers to all forms of nutritional therapies, excluding the specific nutritional therapy defined for use in the intervention group.
    We used Cochrane\'s Screen4Me workflow to assess the initial search results. Two review authors independently screened references that met the inclusion criteria, extracted data, and assessed the risk of bias and the certainty of the evidence using the GRADE approach. We calculated the mean difference (MD) or standardised mean difference (SMD) for continuous data and the odds ratio (OR) for dichotomous data, with 95% confidence intervals (CIs). We assessed heterogeneity using the I2 statistic. The primary outcomes were disability and ADL. We also assessed gait, nutritional status, all-cause mortality, quality of life, hand and leg muscle strength, cognitive function, physical performance, stroke recurrence, swallowing function, neurological impairment, and the development of complications (adverse events) as secondary outcomes.
    We identified 52 eligible RCTs involving 11,926 participants. Thirty-six studies were conducted in the acute phase, 10 in the subacute phase, three in the acute and subacute phases, and three in the chronic phase. Twenty-three studies included patients with ischaemic stroke, three included patients with haemorrhagic stroke, three included patients with subarachnoid haemorrhage (SAH), and 23 included patients with ischaemic or haemorrhagic stroke including SAH. There were 25 types of nutritional supplements used as an intervention. The number of studies that assessed disability and ADL as outcomes were nine and 17, respectively. For the intervention using oral energy and protein supplements, which was a primary intervention in this review, six studies were included. The results for the seven outcomes focused on (disability, ADL, body weight change, all-cause mortality, gait speed, quality of life, and incidence of complications (adverse events)) were as follows: There was no evidence of a difference in reducing disability when \'good status\' was defined as an mRS score of 0 to 2 (for \'good status\': OR 0.97, 95% CI 0.86 to 1.10; 1 RCT, 4023 participants; low-certainty evidence). Oral energy and protein supplements may improve ADL as indicated by an increase in the FIM motor score, but the evidence is very uncertain (MD 8.74, 95% CI 5.93 to 11.54; 2 RCTs, 165 participants; very low-certainty evidence). Oral energy and protein supplements may increase body weight, but the evidence is very uncertain (MD 0.90, 95% CI 0.23 to 1.58; 3 RCTs, 205 participants; very low-certainty evidence). There was no evidence of a difference in reducing all-cause mortality (OR 0.57, 95% CI 0.14 to 2.28; 2 RCTs, 4065 participants; low-certainty evidence). For gait speed and quality of life, no study was identified. With regard to incidence of complications (adverse events), there was no evidence of a difference in the incidence of infections, including pneumonia, urinary tract infections, and septicaemia (OR 0.68, 95% CI 0.20 to 2.30; 1 RCT, 42 participants; very low-certainty evidence). The intervention was associated with an increased incidence of diarrhoea compared to usual care (OR 4.29, 95% CI 1.98 to 9.28; 1 RCT, 4023 participants; low-certainty evidence) and the occurrence of hyperglycaemia or hypoglycaemia (OR 15.6, 95% CI 4.84 to 50.23; 1 RCT, 4023 participants; low-certainty evidence).
    We are uncertain about the effect of nutritional therapy, including oral energy and protein supplements and other supplements identified in this review, on reducing disability and improving ADL in people after stroke. Various nutritional interventions were assessed for the outcomes in the included studies, and almost all studies had small sample sizes. This led to challenges in conducting meta-analyses and reduced the precision of the evidence. Moreover, most of the studies had issues with the risk of bias, especially in terms of the absence of blinding and unclear information. Regarding adverse events, the intervention with oral energy and protein supplements was associated with a higher number of adverse events, such as diarrhoea, hyperglycaemia, and hypoglycaemia, compared to usual care. However, the quality of the evidence was low. Given the low certainty of most of the evidence in our review, further research is needed. Future research should focus on targeted nutritional interventions to reduce disability and improve ADL based on a theoretical rationale in people after stroke and there is a need for improved methodology and reporting.
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  • 文章类型: Case Reports
    食管门失弛缓症是一种以食管运动功能障碍为特征的疾病,导致各种症状,包括呕吐和胸痛.这种疾病没有治愈性的治疗方法,关于营养治疗或康复的共识尚不清楚。在这里,我们介绍了一个90岁的女性,有食道门失弛缓症的症状,2019年冠状病毒病(COVID-19)肺炎后继发性肌肉减少症和肌肉减少性吞咽困难加剧。患者在进行软饮食时出现胸痛和呕吐,食管造影显示典型的食管贲门失弛缓症。她的食道门失弛缓症症状缓解了,随着营养状况的改善,骨骼肌质量,和身体能力,当采用营养和综合康复疗法相结合时。该病例强调,口腔吞咽困难与食管贲门失弛缓症症状恶化有关,营养和康复干预措施可有效缓解食管贲门失弛缓症和肌肉减少症患者的贲门失弛缓症症状。
    Esophageal achalasia is a disease characterized by esophageal motor dysfunction, leading to various symptoms, including vomiting and chest pain. There is no curative treatment for this disease, and the consensus on nutritional therapy or rehabilitation is unclear. Herein, we present the case of a 90-year-old woman with symptoms of esophageal achalasia, exacerbated by secondary sarcopenia and sarcopenic dysphagia after coronavirus disease 2019 (COVID-19) pneumonia. The patient presented with chest pain and vomiting while on a soft diet, and esophagography revealed typical esophageal achalasia. Her esophageal achalasia symptoms resolved, with improvements in nutritional status, skeletal muscle mass, and physical capacity, when a combination of nutritional and comprehensive rehabilitation therapies was adopted. This case highlights that oral dysphagia is associated with worsening esophageal achalasia symptoms and that nutritional and rehabilitative interventions are effective in relieving the symptoms of achalasia in patients with esophageal achalasia and sarcopenia.
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  • 文章类型: Journal Article
    背景:2型糖尿病(T2D)在全球范围内日益受到关注,家庭医生被要求帮助糖尿病患者控制这种慢性疾病,医学营养治疗(MNT)。然而,糖尿病的MNT通常是标准化的,而如果为患者量身定做,效果会更好。为患者量身定制的MNT存在差距,如果解决了,可以支持家庭医生提供有效的建议。在这种情况下,决策支持系统(DSS)是医生支持T2D患者MNT的有价值的工具-只要DSS在决策过程中对人类透明。的确,数据驱动的DSS缺乏透明度可能会阻碍其在临床实践中的采用,因此,家庭医生不得不采用国家医疗保健系统提供的一般营养指南。
    方法:这项工作提出了一个原型的基于本体的临床决策支持系统(OnT2D-DSS),旨在帮助全科医生管理T2D患者。特别是在制定量身定制的饮食计划时,利用临床专家知识。OnT2D-DSS利用形式化为领域本体论的临床专家知识来识别患者的表型和潜在的合并症,为宏观和微观营养素摄入量提供个性化的MNT建议。该系统可以通过原型接口访问。
    结果:进行了两个初步实验,以评估系统提供的推论的质量和正确性以及OnT2D-DSS的可用性和接受度(与营养专家和家庭医生一起进行,分别)。
    结论:总体而言,营养专家认为该系统是准确的,家庭医生认为是有价值的,在实验过程中收集到的未来改进的小建议。
    BACKGROUND: Type-2 Diabetes Mellitus (T2D) is a growing concern worldwide, and family doctors are called to help diabetic patients manage this chronic disease, also with Medical Nutrition Therapy (MNT). However, MNT for Diabetes is usually standardized, while it would be much more effective if tailored to the patient. There is a gap in patient-tailored MNT which, if addressed, could support family doctors in delivering effective recommendations. In this context, decision support systems (DSSs) are valuable tools for physicians to support MNT for T2D patients - as long as DSSs are transparent to humans in their decision-making process. Indeed, the lack of transparency in data-driven DSS might hinder their adoption in clinical practice, thus leaving family physicians to adopt general nutrition guidelines provided by the national healthcare systems.
    METHODS: This work presents a prototypical ontology-based clinical Decision Support System (OnT2D- DSS) aimed at assisting general practice doctors in managing T2D patients, specifically in creating a tailored dietary plan, leveraging clinical expert knowledge. OnT2D-DSS exploits clinical expert knowledge formalized as a domain ontology to identify a patient\'s phenotype and potential comorbidities, providing personalized MNT recommendations for macro- and micro-nutrient intake. The system can be accessed via a prototypical interface.
    RESULTS: Two preliminary experiments are conducted to assess both the quality and correctness of the inferences provided by the system and the usability and acceptance of the OnT2D-DSS (conducted with nutrition experts and family doctors, respectively).
    CONCLUSIONS: Overall, the system is deemed accurate by the nutrition experts and valuable by the family doctors, with minor suggestions for future improvements collected during the experiments.
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