背景:Co-Frisero研究描述了在图林根州Friedrichroda医院爆发的COVID-19疫情,德国,拥有185张床位和404名员工,在3月30日之间的大流行开始时,2020年4月13日,2020年。本研究旨在分析医院员工中SARS-CoV-2传播的潜在来源。
方法:爆发后,我们通过问卷调查和血清阳性率研究进行了全面随访,使用两种不同的IgG检测免疫测定法和第三种不一致结果免疫测定法.
结果:PCR筛查在229名员工中的25名确认了SARS-CoV-2感染,通过血清学检测到另外7个。统计分析表明,患者直接接触,暴露于非隔离房间的高流量通风,与同事直接接触,共用娱乐室,拼车与感染风险增加有关。相反,与家人和朋友联系,公共交通,公共事件,使用更衣室与感染无关。男性感染可能性较低,独立于年龄和其他危险因素。
结论:本研究强调了直接患者护理和内部员工互动在SARS-CoV-2在医院传播中的作用。这表明,在防范大流行时,需要考虑拼车等非传统传播途径。
BACKGROUND: The Co-FriSero study describes a COVID-19 outbreak at the Friedrichroda hospital in Thuringia, Germany, with 185 beds and 404 employees, at the onset of the pandemic between March 30th, 2020, and April 13th, 2020. This study aimed to analyze potential sources of SARS-CoV-2 transmission amongst hospital employees.
METHODS: After the outbreak, a comprehensive follow-up was conducted through a questionnaire and a seroprevalence study using two different immunoassays for IgG detection and a third for discordant results.
RESULTS: PCR screenings confirmed SARS-CoV-2 infection in 25 of 229 employees, with an additional 7 detected through serology. Statistical analysis indicated that direct patient contact, exposure to high flow ventilation in non-isolated rooms, direct contact with colleagues, shared use of recreational rooms, and carpooling were associated with an increased infection risk. Conversely, contact with family and friends, public transportation, public events, and use of locker rooms were not associated with infection. Male gender showed a lower infection likelihood, independent of age and other risk factors.
CONCLUSIONS: This study highlights the role of direct patient care and internal staff interactions in the spread of SARS-CoV-2 in the hospital setting. It suggests that non-traditional transmission routes like carpooling require consideration in pandemic preparedness.