目的:确定昆士兰州北部Mackay-Isaac-Whitsunday地区(-21.14°S)的炎症性肠病(IBD)的发病率,并与澳大利亚南部和新西兰的数据进行比较(吉朗,澳大利亚-38.14°S;塔斯马尼亚-41.43°S和-42.88°S(朗塞斯顿和霍巴特)和坎特伯雷,新西兰-43.46°S)。
方法:2017年6月1日至2018年5月31日进行了一项基于社区人群的前瞻性观察性IBD研究。
方法:主要包括IBD的粗年发病率,克罗恩病(CD),溃疡性结肠炎(UC)和未分类的炎症性肠病(IBDU),而继发性包括疾病表型和行为。
结果:发现56例新的IBD病例。23是CD,30个是UC,3个是IBDU。IBD每100000例的粗年发病率,CD,UC和IBDU为32.2(95%置信区间(CI):24.78-41.84),13.23(95%CI:8.79-19.90),17.25(95%CI:12.06-24.67)和1.73(95%CI:0.56-5.35)。当直接按照世界卫生组织标准人口分布进行年龄标准化时,整个CD,UC和IBDU发病率分别为13.19、17.34和1.85/100000,总体年龄标准化IBD发病率为32.38。
结论:这是第一项在澳大利亚北部人群中定义IBD发病率并在澳大利亚北部和南部之间进行比较的研究。IBD原油是澳大利亚报告的最高原油。像其他人一样,我们在诊断时分别发现上消化道克罗恩病和复杂疾病的发病率高和低,可能反映了内镜手术的可用性增加和早期吸收。
To determine the incidence of inflammatory bowel disease (IBD) in the Mackay-Isaac-Whitsunday region in Northern Queensland (-21.14° S) and to allow a comparison with Southern Australian and New Zealand data (Geelong, Australia -38.14° S; Tasmania -41.43° S and -42.88° S (Launceston and Hobart) and Canterbury, New Zealand -43.46 °S).
A prospective observational community population-based IBD study was conducted between 1 June 2017 and 31 May 2018.
Primary includes the crude annual incidence rate of IBD, Crohn\'s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease-unclassified (IBDU), while secondary includes disease phenotype and behaviour.
Fifty-six new cases of IBD were identified. Twenty-three were CD, 30 were UC and 3 were IBDU. The crude annual incidence rate per 100 000 for IBD, CD, UC and IBDU were 32.2 (95% confidence interval (CI): 24.78-41.84), 13.23 (95% CI: 8.79-19.90), 17.25 (95% CI: 12.06-24.67) and 1.73 (95% CI: 0.56-5.35). When directly age-standardised to the World Health Organisation Standard Population Distribution, the overall CD, UC and IBDU incidence were 13.19, 17.34 and 1.85 per 100 000, with an overall age-standardised IBD incidence of 32.38.
This is the first study to define the incidence of IBD in a Northern Australian cohort and to allow a comparison between North and Southern Australia. The IBD crude is the highest reported in Australia. Like others, we found a high and low incidence of upper gastrointestinal Crohn\'s disease and complicated disease at diagnosis respectively, likely reflective of the increased availability and early uptake of endoscopic procedures.