■规范的儿童运动网络静息状态fMRI有效连接未定义,然而,对于小儿脑瘫的可翻译动态静息状态网络信息评估是必要的。
■在50名神经典型发育5至13岁的儿童中研究了静息状态fMRI的跨光谱动态因果模型。每个半球完全连接的六节点网络模型包括初级运动皮层,纹状体,丘脑底核,苍白球,丘脑,和对侧小脑。具有穷举贝叶斯模型简化和贝叶斯建模平均的参数经验贝叶斯模型为模型提供了信息;PurduePegboard手运动行为的测试分数是组水平的协变量,以确定有效的连通性-功能行为关系。
■尽管两个半球表现出相似的运动皮质-基底神经节-小脑网络的有效连通性,右侧的震级稍大,除了纹状体的左侧连接更多,极性相反。节点间运动网络有效连通性在受试者之间保持一致和稳健。年龄对与对侧小脑的连接有更大的影响,双边。电机行为,然而,影响了每个半球的不同连接,对丘脑底核的左调制连接产生更显著的影响,对侧小脑,初级运动皮层,还有丘脑.
■这项研究揭示了运动网络中5-13岁健康儿童的定向静息状态有效连接的一致模式,包括皮质,皮质下,和小脑区域,与运动技能熟练程度相关。两个半球在运动皮质-基底神经节-小脑网络中表现出相似的有效连通性,反映了其他模态预测的节间信号方向,由于休息时的网络差异,主要不同于任务依赖性研究。值得注意的是,与年龄相关的变化在与对侧小脑的连接中更为明显。相反,运动行为明显影响每个半球的连接,强调其在调节左侧与丘脑底核的连接中的作用,对侧小脑,初级运动皮层,还有丘脑.运动网络有效连通性与运动行为相关,验证其生理意义。这项研究是第一个使用静息状态功能MRI与行为相关评估儿科运动网络的规范有效连接模型,并作为识别异常发现和优化深部脑刺激等针对性干预措施的基础。潜在的影响未来的治疗方法为儿童运动障碍。
UNASSIGNED: Normative childhood motor network resting-state fMRI effective connectivity is undefined, yet necessary for translatable dynamic resting-state-network-informed evaluation in pediatric cerebral palsy.
UNASSIGNED: Cross-spectral dynamic causal modeling of resting-state-fMRI was investigated in 50 neurotypically developing 5- to 13-year-old children. Fully connected six-node network models per hemisphere included primary motor cortex, striatum, subthalamic nucleus, globus pallidus internus, thalamus, and contralateral cerebellum. Parametric Empirical Bayes with exhaustive Bayesian model reduction and Bayesian modeling averaging informed the model; Purdue Pegboard Test scores of hand motor behavior were the covariate at the group level to determine the effective-connectivity-functional behavior relationship.
UNASSIGNED: Although both hemispheres exhibited similar effective connectivity of motor cortico-basal ganglia-cerebellar networks, magnitudes were slightly greater on the right, except for left-sided connections of the striatum which were more numerous and of opposite polarity. Inter-nodal motor network effective connectivity remained consistent and robust across subjects. Age had a greater impact on connections to the contralateral cerebellum, bilaterally. Motor behavior, however, affected different connections in each hemisphere, exerting a more prominent effect on the left modulatory connections to the subthalamic nucleus, contralateral cerebellum, primary motor cortex, and thalamus.
UNASSIGNED: This study revealed a consistent pattern of directed resting-state effective connectivity in healthy children aged 5-13 years within the motor network, encompassing cortical, subcortical, and cerebellar regions, correlated with motor skill proficiency. Both hemispheres exhibited similar effective connectivity within motor cortico-basal ganglia-cerebellar networks reflecting inter-nodal signal direction predicted by other modalities, mainly differing from task-dependent studies due to network differences at rest. Notably, age-related changes were more pronounced in connections to the contralateral cerebellum. Conversely, motor behavior distinctly impacted connections in each hemisphere, emphasizing its role in modulating left sided connections to the subthalamic nucleus, contralateral cerebellum, primary motor cortex, and thalamus. Motor network effective connectivity was correlated with motor behavior, validating its physiological significance. This study is the first to evaluate a
normative effective connectivity model for the pediatric motor network using resting-state functional MRI correlating with behavior and serves as a foundation for identifying abnormal findings and optimizing targeted interventions like deep brain stimulation, potentially influencing future therapeutic approaches for children with movement disorders.