背景:尽管非结核分枝杆菌(NTM)感染是全球肺部疾病的常见原因,很少有研究关注与安徽省NTM病例相关的流行病学和治疗因素,中国。这项回顾性研究旨在确定病因和临床因素,安徽省NTM肺病(NTMPD)患者的治疗结果。
方法:回顾性分析2019年7月至2022年6月在安徽省胸科医院就诊的NTMPD患者的病历资料。比较两组患者的治疗结果:一组接受标准化的NTM治疗方案,另一组接受精确治疗方案。
结果:对672个临床NTMPD相关分离株的基因型分析显示,大多数是细胞内分枝杆菌,而药物敏感性试验结果显示这些分离株具有不同的抗生素耐药性。咳嗽是101例NTMPD患者最常见的症状。两组患者均接受治疗后,症状改善,观察到一些患者的痰培养转化,影像学检查结果稳定;然而,两组间治疗结局无统计学差异.
结论:在这项研究中,胞内分枝杆菌是在从NTMPD患者获得的分离物中鉴定的主要NTM物种。我们的患者分离株的耐药性分布很复杂,强调及时管理的必要性,更有效,安徽省NTMPD患者的标准化治疗,中国。
BACKGROUND: Although nontuberculous mycobacterial (NTM) infection is a common cause of pulmonary disease worldwide, few studies have focused on epidemiological and therapeutic factors related to NTM cases in Anhui Province, China. This retrospective study aimed to identify aetiological and clinical factors, and treatment outcomes of patients with NTM pulmonary disease (NTMPD) in Anhui.
METHODS: Retrospective clinical data obtained from medical records of NTMPD patients seeking care at Anhui Chest Hospital from July 2019 to June 2022 were analyzed. Treatment outcomes were compared between two patient groups: one receiving a standardised NTM treatment regimen and the other receiving precision treatment regimens.
RESULTS: Genotypic analysis of 672 clinical NTMPD-associated isolates revealed that most were Mycobacterium intracellulare, while drug-susceptibility test results demonstrated diverse antibiotic resistance profiles for these isolates. Cough was the most common symptom for 101 NTMPD patients. After patients of both groups received treatment, symptoms improved, sputum culture conversion was observed for some patients, imaging findings stabilised; however, no statistically significant intergroup differences in treatment outcomes were found.
CONCLUSIONS: In this study, M. intracellulare was the predominant NTM species identified in isolates obtained from NTMPD patients. Drug resistance profiles of our patient isolates were complex, highlighting the need for administration of timely, more effective, standardised treatments for patients with NTMPD in Anhui Province, China.