卤化有机化合物(HOCs)是一类具有高毒性的污染物,低生物降解性,和高生物累积潜力,特别是氯化和溴化HOCs(Cl/Br-HOCs)。关于新型Cl/Br-HOC是否可以穿透胎盘屏障并导致不良分娩结局的知识差距。在这里,在济南某医院采集脐带血326份,2017年2月至2022年1月,山东省根据非目标方法确定了44个Cl/Br-HOC,其通信置信水平高于4。涵盖兽药,杀虫剂,以及他们的转型产品,药品和个人护理产品,消毒副产物,等等。据我们所知,Closantel的存在,溴苯腈,4-羟基-2,5,6-三氯间苯二甲酸,2,6-二溴-4-硝基苯酚,首次报道脐带血样本中的相关成分。多元线性回归(MLR)和贝叶斯核机回归(BKMR)模型均用于评估新生儿出生结局的关系(出生体重,长度,和体重指数)与单独的Cl/Br-HOC和Cl/Br-HOC混合物接触,分别。观察到五氯苯酚暴露与新生儿出生长度之间存在显着负相关,但是在错误发现率校正后,重要性消失了。BKMR分析显示Cl/Br-HOCs混合物暴露与新生儿出生身长减少显著相关,表明胎儿生长受限的风险较高。我们的发现提供了早期生命阶段Cl/Br-HOCs暴露的概述,并增强了对其暴露风险的理解。
Halogenated organic compounds (HOCs) are a class of contaminants showing high toxicity, low biodegradability, and high bioaccumulation potential, especially chlorinated and brominated HOCs (Cl/Br-HOCs). Knowledge gaps exist on whether novel Cl/Br-HOCs could penetrate the placental barrier and cause adverse birth outcomes. Herein, 326 cord blood samples were collected in a hospital in Jinan, Shandong Province from February 2017 to January 2022, and 44 Cl/Br-HOCs were identified with communicating confidence level above 4 based on a nontarget approach, covering veterinary drugs, pesticides, and their transformation products, pharmaceutical and personal care products, disinfection byproducts, and so on. To our knowledge, the presence of closantel, bromoxynil, 4-hydroxy-2,5,6-trichloroisophthalonitrile, 2,6-dibromo-4-nitrophenol, and related components in cord blood samples was reported for the first time. Both multiple linear regression (MLR) and Bayesian kernel machine regression (BKMR) models were applied to evaluate the relationships of newborn birth outcomes (birth weight, length, and ponderal index) with individual Cl/Br-HOC and Cl/Br-HOCs mixture exposure, respectively. A significantly negative association was observed between pentachlorophenol exposure and newborn birth length, but the significance vanished after the false discovery rate correction. The BKMR analysis showed that Cl/Br-HOCs mixture exposure was significantly associated with reduced newborn birth length, indicating higher risks of fetal growth restriction. Our findings offer an overview of Cl/Br-HOCs exposome during the early life stage and enhance the understanding of its exposure risks.