背景:鼻腭管囊肿(NDC)是口腔中最常见的非牙源性囊肿。临床上,根据临床和影像学表现来怀疑这些病变并不难。然而,由于这些病变的形态多样性,组织病理学诊断可能很困难。目的是分析巴西东北部两个口腔颌面病理服务机构诊断的NDC的临床病理特征。
方法:进行回顾性临床病理研究。分析了来自巴西两个口腔颌面病理学服务机构的18,121例口腔病变临床记录(2000-2020年)。所有NDC病例都经过修订,人口统计学,临床,射线照相,并收集组织病理学数据。
结果:在口腔病理学服务的18,121次诊断中,45(0.2%)为NDC。该系列包括24名男性(53.3%)和21名女性(46.7%),平均年龄43.2岁.大多数病变无症状(n=27,60%),平均大小为2.1cm。微观上,非角化复层鳞状上皮最常见(66.7%).然而,在88.9%的病例中,上皮内膜变化,由两种或两种以上类型的上皮组成。上皮的类型和囊肿的大小之间没有显着关联(p=0.389)。神经,血管,出血,和慢性炎症浸润常见。相比之下,粘液腺体的频率很低,皮脂腺,胆固醇裂口,多核巨细胞.
结论:临床,射线照相,在这项研究中观察到的微观发现与文献中报道的相似。由于NDC的形态多样性,需要将其组织病理学特征与临床和影像学检查结果相关联,以建立正确的诊断。
BACKGROUND: Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. The objective was to analyze the clinicopathological features of NDCs diagnosed in two oral and maxillofacial pathology services in the Brazilian northeast.
METHODS: A retrospective clinicopathologic study was performed. A total of 18,121 clinical records of oral lesions from two oral and maxillofacial pathology services in Brazil were analyzed (2000-2020). All NDCs cases were revised and demographic, clinical, radiographic, and histopathological data were collected.
RESULTS: Among 18,121 diagnoses in the oral pathology services, 45 (0.2%) were NDCs. The series comprises 24 males (53.3%) and 21 females (46.7%), with a mean age of 43.2 years-old. Most lesions were asymptomatic (n = 27, 60%) with an mean size of 2.1 cm. Microscopically, the non-keratinized stratified squamous epithelium was the most common (66.7%). However, in 88.9% of cases, the epithelial lining was varied and composed of two or more types of epithelium. There was no significant association between the type of epithelium and the size of the cysts (p = 0.389). Nerve, blood vessels, hemorrhage, and chronic inflammatory infiltrate were commonly observed. In contrast, there was a low frequency of mucous glands, sebaceous glands, cholesterol clefts, and multinucleated giant cells.
CONCLUSIONS: The clinical, radiographic, and microscopic findings observed in this study are similar to those reported in the literature. Due to the morphological diversity of NDC, it is needed to correlate its histopathological features with the clinical and radiographic findings to establish a correct diagnosis.